Sevilla CF, Bernet L, Martínez BM, Ramírez CAK, Laguna AC

Language: Spanish
References: 15
Page: 187-191
PDF size: 415.85 Kb.

ABSTRACT

Pigmented epithelioid melanocytoma is a recently entity encompassing synthesizing pigmented melanomas, animal type melanomas and epithelioid blue nevus occurring sporadically or in the Carney complex syndrome, characterized by his great size, deep, low pleomorphism, great amount of pigment and scant mitoses. Although pigmented epithelioid melanocytoma frequently metastasize to the lymph nodes, they have a more favourable outcome than conventional melanomas. We believe they should be considerated as melanocytic borderline tumours or low grade melanocytic tumours that could be treated with limited excision.

REFERENCES

1. Zembowicz A, Carney JA, Mihm CMJ. Pigmented epitheliod melanocytoma, a low grade melanoma indistinguishable from aninmal type melanoma and epitheliod nevus. Am J Surg Pathol. 2004; 28: 31-40.

2. Crowson AN, Magro CM, Mihm CMJ. Malignant melanoma with prominent pigment synthesis: “animal type” melanoma a clinical and histologycal study of six cases with a consideration of other melanocytic neoplasms with prominent pigment synthesis. Hum Pathol. 1999; 30: 543-550.

3. Carney JA, Ferreiro JA. The epithelioid blue nevus. A multicentric familial tumor with important associations, including cardiac mixoma and psammomatous schwannoma. Am J Surg Pathol. 1996; 20: 259-272.

4. O’Grady TC, Barr RJ, Billman G, Cunningham BB. Epithelioid blue nevus occurring in children with no evidenice of Carney complex. Am J Dermatopathol. 1999; 21: 483-486.

5. Zembowicz A, Knoepp SM, Bei T, Stergiopoulos S, Eng C, Mihm MC et al. Loss of expression of protein kinase a regulatory subunit 1 alpha in pigmented epithelioid melanocitoma but not in melanoma or other melanocytic lesions. Am J Surg Pathol. 2007; 31: 1764-1775.

6. Mandal RJ, Murali R, Lundquist KF, Ragsdale BD, Heenan P, McCarthy SW et al. Pigmented epithelioid melanocytoma: favorable outcome after 5-year follow-up. Am J Surg Pathol. 2009; 33: 1778-1782.

7. Levene A. Disseminated dermal melanocytosis terminating in melanoma: a human condition resembling equine melanocytic disease. Br J Dermatol. 1979; 101: 197-205.

8. Carney JA, Gordon H Carpenter PC, Shenaj BV, Go VL. The complex of myxomas, spotty pigmentation, and endocrine over activity. Medicine (Baltimore). 1985; 64: 270-283.

9. Zembowick A, Mihm C. Pigmented synthesizing melanocytic tumor animal/equine-type melanoma): a low-grade melanoma with marked resemblance to epithelioid blue nevus (Abstract). J Cutan Pathol. 2001; 28: 590.

10. Fossati L. Melanoma de tipo animal. Dermatol Argent. 2010; 16: 354-358.

11. Park HY, Gilchrest BA. Signaling pathways mediating melanogenesis. Cell Mol Biol (Noisy-le-grand). 1999; 45: 919-930.

12. Smith KJ, Barret TL, Skelton HG, Lupton GP, Graham JH. Spindle cell and epithelioid cell nevi with atypia and metastasis (malignant Spitz nevus). Am J Surg Pathol. 1989; 13: 931-939.

13. Wong TY, Suster S, Duncan LM, Mihm MC Jr. Nevoid melanoma: a clinicopathological study of seven cases of malignant melanoma mimicking spindle and epithelioid cell nevus and verrucous dermal nevus. Hum Pathol. 1195; 26: 171-179.

14. Cecchi R, Rapicano V. Pigment synthesysing (animal-type) melanoma with satellite metastasis. Eur J Dermatol. 2007; 17: 335-336.

15. Vezzoni JM, Martini L, Ricci C. A case of animal-type melanoma (or pigmented epithelioid melanocytoma?): an open prognosis. Dermatol Surg. 2008; 34: 105-110.