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Academia Mexicana de Neurología, A.C.

2015, Number 4

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Rev Mex Neuroci 2015; 16 (4)

Hippocampal function in memory processing and its deterioration in aging

Aguirre SEE

Language: Spanish
References: 35
Page: 21-30
PDF size: 153.78 Kb.


ABSTRACT

This article reviews the role of the hippocampus in memory processing and its deterioration during aging in humans and animals, where even the neurochemical mechanisms underlying the decline in mnemonic ability are in process of understanding. Some aspects of the physiology of hippocampal will be developed, the type of memory depending on the hippocampal function will be discussed, and the molecular pathways that regulate memory function will be studied. Finally, it will be discuss the involvement of these mechanisms in the deterioration that occurs with this cognitive function during aging. It is concluded that the evidence suggests that deregulation of several signaling pathways, among which plays a central role the brain-derived neurotrophic factor, explains, ultimately, deterioration of memory in senescent organisms.


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