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ISSN 1405-1699 (Print)
Órgano Oficial del Colegio Mexicano de Alergia, Asma e Inmunología Pediátrica y de la Asociación Latinoamericana de Pediatría

2016, Number 1

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Alerg Asma Inmunol Pediatr 2016; 25 (1)

Asthma: Immunological mechanisms involved and polymorphisms associated with predisposition to pathology. (Asthma related to single nucleotide polymorphisms)

Meza VR, Rosales GMG, Saucedo AAG

Language: Spanish
References: 28
Page: 6-11
PDF size: 230.33 Kb.


ABSTRACT

Asthma is a chronic respiratory disease that often originates in early childhood. Although candidate gene studies have identified many potential asthma susceptibility genes in adult populations, few have studied associations with immune phenotypes in the childhood, that might be early clinical markers of asthma. The aim of this review is understand current discoveries at the molecular level, emphasizing research of associated polymorphisms in genes of histamine metabolizing enzymes such as histidine decarboxilase, histamine N-methyl-transferase and diamine oxidase (HDC, HNMT and DAO), and others polymorphisms of genes related with immune regulation determining predisposition to asthma in pediatric patients. Future research on this and other single nucleotide polymorphisms (SNPs) can help to identify new markers and therapeutic targets in particular phenotypes in this pathology.


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