2015, Number 2
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Rev Mex Neuroci 2015; 16 (2)
Utility of the memantine in late cognitive deterioration secondary to radiotherapy: Case report and literature review
Schiappacasse-Cocio G, González-Soto P
Language: Spanish
References: 14
Page: 62-69
PDF size: 206.91 Kb.
ABSTRACT
Introduction: Late CNS complications secondary to radiotherapy
are more frequently seen, affecting significantly the patients’ quality
of life. There is no approved pharmacological treatment for this type of
late cognitive decline.
Case report: We evaluated clinically a patient with late cognitive
decline attributed to radiotherapy. A trial with memantine showed
benefits on his cognitive performance. A statistical analysis was in use
type goodness of fit with statistics chi square, to evaluate the impact of
the medicament in this case with cognitive late dysfunction. There was
obtained a beneficial not attributable result at random.
Conclusions: Memantine could be useful in the treatment of
late cognitive decline due to radiotherapy. However, it is necessary
information derived from clinical trials to conclude that memantine is
effective in tardive dementia associated with radiotherapy.
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