2011, Number 2
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Ann Hepatol 2011; 10 (2)
Chronic HBV with pregnancy: Reactivation flare causing fulminant hepatic failure
Singhal A, Kanagala R, Jalil S, Wright HI, Kohli V
Language: English
References: 21
Page: 233-236
PDF size: 36.51 Kb.
ABSTRACT
Chronic HBV infection is a dynamic state of interaction between HBV, hepatocytes, and the immune system
of the host. A series of reactivation flares and remissions may occur due to multiple causes. Among
them, spontaneous reactivation and immunosuppressive drugs including steroids or cancer chemotherapy
are well known. This is due to immune-mediated destruction of HBV-expressing cells following withdrawal
of immunosuppressive effect. Few cases have been reported in females during postpartum period. We report
a case of fulminant hepatic failure during pregnancy in a previously unrecognized hepatitis B positive
female requiring emergent liver transplantation.
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