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2015, Number 4

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Finlay 2015; 5 (4)

Clinical and epidemiological characterization of patients with rheumatoid arthritis

González OZA, Egüez MJL, Fusté JC, Reyes MEA, Borges LJA, González OLH

Language: Spanish
References: 37
Page: 264-274
PDF size: 460.94 Kb.


ABSTRACT

Background: rheumatoid arthritis is a chronic systemic inflammatory disease, it has varied clinical manifestations and cause different degrees of discomfort and disability.
Objective: to conduct a clinical and epidemiological characterization of all rheumatoid arthritis patients admitted to the clinical services of the Arnaldo Milián Castro Provincial University Hospital.
Methods: a cross-sectional study was conducted in the clinical services of the Arnaldo Milián Castro University Hospital from 2009 through 2013. The universe consisted of 280 patients hospitalized due to rheumatoid arthritis. The following variables were studied: age, sex, skin color, past medical history, clinical manifestations, complications, affected organs, time of diagnosis and treatment. Chi square and prevalence ratio with a 95% confidence interval were calculated.
Results: arthritis was found in 2 men every 5 women. White middle-aged patients predominated. Hypertension was the major illness described in the past medical history. Arthralgia and movement limitations prevailed. No family history of rheumatic disease was found. The time of diagnosis was less than six months and infection was among the most frequent complications. The most common treatment was the combination of non-steroidal anti-inflammatory drugs and steroids, especially in seropositive patients.
Conclusions: rheumatoid arthritis was more common in females and white middle-aged patients. Hypertension was the major illness found in the past medical history. Patients with two target organs affected predominated. Arthralgia and movement limitations prevailed in the clinical picture. The most common treatment was the combination of non-steroidal anti-inflammatory drugs and steroids.


REFERENCES

  1. Krieckaert CL, Lems WF. Biologicals and bone loss. Ther Adv Musculoskelet Dis. 2012;4(4):245-7

  2. Klareskog L, Catrina AI, Paget S. Rheumatoid arthritis. Lancet. 2009;373(9664):659-72

  3. Macedo A, Oakley S, Gullick N, Kirkham B. An examination of work instability, functional impairment, and disease activity in employed patients with rheumatoid arthritis. J Rheumatol. 2009;36(2):225-30

  4. Gamboa R, Medina M, Acevedo E, Pastor C, Cucho M, Gutiérrez C, et al. Prevalencia de enfermedades reumatológicas y discapacidad en una comunidad urbana-marginal: resultados del primer estudio COPCORD en el Perú. Rev Peru Reumatol. 2009;15(1):40-6

  5. Lacativa PG, Farias ML. Osteoporosis and inflammation. Arq Bras Endocrinol Metabol. 2010;54(2):123-32

  6. Mora C, González A, Díaz J, Quintana G. Costos directos de la artritis reumatoide temprana en el primer año de atención: simulación de tres situaciones clínicas en un hospital universitario de tercer nivel de Colombia. Biomédica. 2009;29(1):43-50

  7. Acevedo EM. Algunos aspectos de la artritis reumatoide en Perú. Rev Soc Peru Med Interna. 2012;25(1):56-67

  8. Kang KY, Lee KY, Kwok SK, Ju JH, Park KS, Hong, YS, et al. The change of bone mineral density according to treatment agents in patients with ankylosing spondylitis. Joint Bone Spine. 2011;78(2):188-93

  9. Aletaha D, Neogi T, Silman A, Funovits J, Felson D, Bingham C. Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum. 2010;62(9):2569-81

  10. Li P, Blum MA, Von J, Hennessy S, Doshi JA. Adherence, discontinuation, and switching of biologic therapies in medicaid enrollees with rheumatoid arthritis. Value Health. 2010;13(6):805-22

  11. Blanco FJ, Ballina J, Carbonell J, Martín E, Tornero J, Ramírez E, et al. Descriptive study of the use of DMARD in patients with rheumatoid arthritis or persistent arthritis who start drug treatment in Spain (FIRST). Reumatol Clin. 2011;7(2):88-93

  12. Peláez I, Sanin LH, Moreno J, Álvarez J, Burgos R, Garza M, et al. Epidemiology of the rheumatic diseases in Mexico. A study of 5 regions based on the COPCORD methodology. J Rheumatol Suppl. 2011;86(1):3-8

  13. Massardo L, Suárez ME, Cardiel MH, Nava A, Levy RA, Laurindo I, et al. Management of patients with rheumatoid arthritis in Latin America. A consensus position paper from Pan-American League of Associations of Rheumatology and Grupo Latino Americano de estudio de Artritis Reumatoide. J Clin Rheumatol. 2009;15(4):203-10

  14. Alonso E, Bravo JM, Rubio E, Gil E, Gantes MA. Glucocorticoides en artritis reumatoide: ¿casi siempre o casi nunca?. Reumatol Clin. 2011;7(6):407-11

  15. Massardo L, Pons BA, Wojdyla D, Cardiel MH, Galarza CM, Sac-nun MP, et al. Early rheumatoid arthritis in Latin America: low socioeconomic status relates to high disease activity at baseline. Arthritis Care Res (Hoboken). 2012;64(8):1135-43

  16. Singh JA, Holmgren AR, Noorbaloochi S. Accuracy of veterans administration databases for a diagnosis of rheumatoid arthritis. Arthritis Rheum. 2004;51(6):952-7

  17. Criswell LA, Gregersen PK. Current understanding of the genetic aetiology of rheumatoid arthritis and likely future developments. Rheumatology (Oxford). 2005;44 Suppl 4:9-13

  18. Raaschou P, Simard JF, Neovius M, Askling J; Anti-Rheumatic Therapy in Sweden Study Group. Does cancer that occurs during or after anti-tumor necrosis factor therapy have a worse prognosis?: A national assessment of overall and site-specific cancer survival in rheumatoid arthritis patients treated with biologic agents. Arthritis Rheum. 2011;63(7):1812-22

  19. Baker JF, Baker DG, Toedter G, Shults J, Von JM, Leonard MB. Associations between vitamin D, disease activity, and clinical response to therapy in rheumatoid arthritis. Clin Exp Rheumatol. 2012;30(5):658-64

  20. Arboleya L, Castaneda S. Osteoinmunología: el estudio de la relación entre el sistema inmune y el tejido óseo. Reumatol Clin. 2013;9(5):303-15

  21. Rossini M, Maddali S, La Montagna G, Minisola G, Malavolta N, Bernini L, et al. Vitamin D deficiency in rheumatoid arthritis:prevalence, determinants and associations with disease activity and disability. Arthritis Res Ther. 2012;12(6):216

  22. Matuszewska A, Szechiński J. Evaluation of Selected Bone Metabolism Markers in Rheumatoid Arthritis Patients. Adv Clin Exp Med. 2013;22(2):193-202

  23. Acevedo EM. Algunos aspectos de la artritis reumatoide en Perú. Rev Soc Peru Med Interna. 2012;25(1):65-9

  24. Gabriel SE, Michaud K. Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases. Arthritis Res Ther. 2009;11(3):229

  25. Aragón LS. Artritis reumatoidea. Memorias del VI simposio actualizaciones en enfermería [Internet]. Cali: Congreso De Enfermería; 2013 [citado 24 Mar 2015]. Disponible en: http://www.encolombia.com/medicina/enfermeria /memorias.html

  26. Bykerk VP, Akhavan P, Hazlewood GS, Schieir O, Dooley A, Haraoui B, et al. Canadian Rheumatology Association Recommendations for the pharmacological management of rheumatoid arthritis with traditional and biologic disease-modifying antirheumatic drugs. J Rheumatol. 2012;39(8):1559-82

  27. Bombardier C, Hazlewood GS, Akhavan P, Schieir O, Dooley A, Haraoui B, et al. Canadian Rheumatology Association recommendations for the pharmacological management of rheumatoid arthritis with traditional and biologic disease-modifying antirheumatic drugs: part II. Safety. J Rheumatol. 2012;39(8):1583-602

  28. Burgos R, Catoggio LJ, Galarza C, Ostojich K, Cardiel MH. Current therapies in rheumatoid arthritis: a Latin American perspective. Reumatol Clin. 2013;9(2):106-12

  29. Cardiel MH. Treat to target strategy in rheumatoid arthritis: real benefits. Reumatol Clin. 2013;9(2):101-5

  30. Tornero J, Sanmartí R, Rodríguez V, Martín E, Marenco JL, González I, et al. Update of the Consensus Statement of the Spanish Society of Rheumatology on the management of biologic therapies in rheumatoid arthritis. Reumatol Clin. 2010;6(1):23-36

  31. Smolen JS, Landewé R, Breedveld FC, Buch M, Burmester G, Dougados M, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs. Ann Rheum Dis. 2014;73(3):492-509

  32. Westhovens R, Robles M, Ximenes AC, Nayiager S, Wollenhaupt J, Durez P, et al. Clinical efficacy and safety of abatacept in methotrexate-naïve patients with early rheumatoid arthritis and poor prognostic factors. Ann Rheum Dis. 2009;68(12):1870-7

  33. Wells AF, Westhovens R, Reed DM, Fanti L, Becker JD, Covucci A, et al. Abatacept plus methotrexate provides incremental clinical benefits versus methotrexate alone in methotrexate-naive patients with early rheumatoidarthritis who achieve radiographic nonprogression. J Rheumatol. 2011;38(11):2362-8

  34. Bukhari M, Abernethy R, Deighton C, Ding T, Hyrich K, Lunt M, et al. BSR and BHPR guidelines on the use of rituximab in rheumatoid arthritis. Rheumatology. 2011;50(12):2311-3

  35. Fleischmann R, Cutolo M, Genovese MC, Lee EB, Kanik KS, Sadis S. Phase IIb dose-ranging study ofthe oral JAK inhibitor tofacitinib (CP-690,550) or adalimumab monotherapy versus placebo in patients with active rheumatoid arthritis with an inadequate response to disease-modifying antirheumatic drugs. Arthritis Rheum. 2012;64(3):617-29

  36. Kremer JM, Bloom BJ, Breedveld FC, Coombs JH, Fletcher MP, Gruben D. The safety and efficacy of JAK inhibitorin patients with active rheumatoid arthritis: results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo. Arthritis Rheum. 2009;60(7):1895-905

  37. da Mota LM, Cruz BA, Brenol CV, Pereira IA, Rezende LS, Bertolo MB, et al. 2012 Brazilian Society of Rheumatology Consensus for the treatment of rheumatoid arthritis. Rev Bras Reumatol. 2012;52(2):135-74




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