2005, Number 08
<< Back Next >>
Ginecol Obstet Mex 2005; 73 (08)
New biochemical and molecular aspects of estrogen's action
Teppa GAD, Terán DJ
Language: Spanish
References: 31
Page: 436-442
PDF size: 83.76 Kb.
ABSTRACT
Estrogens have several biologic actions. The specific nuclear actions of estrogens are determined by the hormone structure, the isoform subtype of the involved estrogen receptor, the characteristics of the target gene promoter, and the balance between coactivator and corepressor proteins that modulate the final transcriptional response of the complex between estrogens and its receptors. In this review we focus on the new biochemical and molecular aspects of the estrogens action.
REFERENCES
Terán Dávila J, Teppa Garrán AD. Actualidad en el tratamiento de la osteoporosis posmenopáusica. Rev Obstet Ginecol Venez 2003;63:135-48.
Febres Balestrini F. Interacción hormonal y fisiológica de la glándula mamaria. En: Terán Dávila J, Febres Balestrini F, editores. Endocrinología ginecológica y reproducción humana. Caracas: Ateproca, 1995;pp:109-27.
Krivoy J. Alteraciones del sistema nervioso central durante el climaterio y la menopausia. En: Terán Dávila J, Febres Balestrini F, editores. Medicina del climaterio y la menopausia. Caracas: Ateproca, 1999;pp:177-85.
Palacios A. Efecto de la terapia hormonal de reemplazo sobre la enfermedad vascular ateroesclerótica. En: Terán Dávila J, Febres Balestrini F, editores. Medicina del climaterio y la menopausia. Caracas: Ateproca, 1999;pp:279-90.
Turmero J. El endometrio humano: aspectos estructurales, autocrinos, paracrinos y endocrinológicos. En: Terán Dávila J, Febres Balestrini F, editores. Endocrinología ginecológica y reproducción humana. Caracas: Ateproca, 1995;pp:129-73.
Gruber CJ, Tschugguel W, Schneeberger C, Huber JC. Production and actions of estrogens. N Engl J Med 2002;346:340-52.
Terán Dávila J, Febres Balestrini F, Pardo Palma R. Foliculogénesis y síntesis de esteroides ováricos. En: Terán Dávila J, Febres Balestrini F, editores. Endocrinología ginecológica y reproducción humana. Caracas: Ateproca, 1995;pp:43-76.
O’Malley BW, Strott CA. Hormonas esteroides: metabolismo y mecanismo de acción. En: Yen SSC, Jaffe RB, editores. Endocrinología de la reproducción. Fisiología, fisiopatología y manejo clínico. Buenos Aires: Médica Panamericana, 1993;pp:179-203.
Huang J, Li X, Yi P, Hilf R, Bambara RA, Muyan M. Targeting estrogen responsive elements (EREs): design of potent transactivators for ERE-containing genes. Mol Cell Endocrinol 2004;218:65-78.
Kumar V, Chambon P. The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer. Cell 1988;55:145-56.
Speroff L, Glass RH, Kase NG. Clinical gynecologic endocrinology and infertility. 6th ed. Baltimore: Lippincott Williams & Wilkins, 1999.
Tsai M, Clark JH, Schrader WT, O’Malley BW. Mechanisms of action of hormones that act as transcription-regulatory factors. In: Wilson JD, Foster DW, Kronenberg HM, Larsen PR, editors. Williams textbook of endocrinology. 9th ed. Philadelphia: WB Saunders, 1998;pp:55-94.
Osborne CK, Zhao HH, Fuqua SAW. Selective estrogen receptor modulators: structure, function, and clinical use. J Clin Oncol 2000;18:3172-86.
Paige LA, Christensen DJ, Gron H, Norris JD, Gottlin EB, Padilla KM, et al. Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta. Proc Natl Acad Sci USA 1999;96:3999-4004.
Matthews J, Gustafsson JA. Estrogen signaling: a subtle balance between ER alpha and ER beta. Mol Interv 2003;3:281-92.
Edwards DP, Boonyaratanakornkit V. Rapid extranuclear signaling by the estrogen receptor (ER): MNAR couples ER and Src to the MAP kinase signaling pathway. Mol Interv 2003;3:12-15.
Collins P, Webb C. Estrogen hits the surface. Nat Med 1995;5:1130-1.
Tsai M, O’Malley BW. Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Annu Rev Biochem 1994;63:451-86.
Green S, Walter P, Kumar V. Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature 1986;320:134-9.
Kuiper GG, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson JA. Cloning of a novel estrogen receptor expressed in rat prostate and ovary. Proc Natl Acad Sci USA 1996;93:5925-30.
Ogawa S, Inoue S, Watanabe T, Hiroi H, Orimo A, Hosoi T, et al. The complete primary structure of human estrogen receptor beta (hER-beta) and its heterodimerization with ER alpha in vivo and in vitro. Biochem Biophys Res Commun 1998;243:122-6.
Cowley S, Parker MG. A comparison of transcriptional activation by ER alpha and ER beta. J Steroid Biochem Mol Biol 1999;69:165-75.
Warner M, Wang L, Weihua Z, Cheng G, Sakaguchi H, Saji S, et al. Analysis of estrogen receptor expression in tissues. Methods Enzymol 2003;364:448-63.
Bord S, Horner A, Beavan S, Compston J. Estrogen receptors alpha and beta are differentially expressed in developing human bone. J Clin Endocrinol Metab 2001;86:2309-14.
Tzuckerman MT, Esty A, Santiso-Mere D, Danielian P, Parker MG, Stein RB, et al. Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions. Mol Endocrinol 1994;8:21-30.
Hall JM, McDonnell DP. The estrogen receptor beta-isoform (ER beta) of the human estrogen receptor modulates ER alpha transcriptional activity and is a regulator of the cellular response to estrogen and antiestrogens. Endocrinology 1999;140:5566-78.
Weigel NL. Steroid hormone receptors and their regulation by phosphorylation. Biochem J 1996;319:657-67.
Kato S, Endoh H, Masuhiro Y. Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science 1995;270:1491-6.
Lee AV, Jackson JG, Gooch JL. Enhancement of insulin-like growth factor signaling in human breast cancer: estrogen regulation of insulin receptor substrate-1 expression in vitro and in vivo. Mol Endocrinol 1999;13:787-96.
Aronica SM, Katzenellenbogen BS. Stimulation of estrogen receptor- mediated transcription and alteration in the phosphorylation state of the rat uterine estrogen receptor by estrogen, cyclic adenosine monophosphate, and insuline-like growth factor-I. Mol Endocrinol 1993;7:743-52.
Ignar-Trowbridge DM, Teng CT, Ross KA, Parker MG, Korach KS, McLachlan JA. Peptide growth factors elicit estrogen receptor-dependent transcriptional activation at an estrogen-responsive element. Mol Endocrinol 1993;7:992-8.