2015, Number 2
<< Back Next >>
Rev Mex Periodontol 2015; 6 (2)
New genomic view of periodontal diseases
Iturbe M, Zerón A
Language: Spanish
References: 12
Page: 74-76
PDF size: 235.10 Kb.
ABSTRACT
The new advances in genome, epigenome and microbiome have allowed to understand the pathogenic mechanisms of periodontal disease, how it develops, and the relationship with the classic concepts of host, environment and biofilm. Applying these concepts to the clinic can lead to a better understanding of the pathogenesis of the disease and thus, to develop new diagnostic tests that can help us identify risk factors in our patients, predict the course and the biological process, and develop a better and more personalized treatment for them.
REFERENCES
Zerón A. Odontología genómica. La medicina oral del siglo XXI. Rev ADM. 2006; 63 (2): 52-61.
Laine ML, Crielaard W, Loos BG. Genetic susceptibility to periodontitis. Periodontol 2000. 2012; 58: 37-68.
Freitag-Wolf S, Dommisch H, Graetz C, Jockel-Schneider Y, Harks I, Staufenbiel I et al. Genome-wide exploration identifies sex-specific genetic effects of alleles upstream NPY to increase the risk of severe periodontitis in men. J Clin Periodontol. 2014; 41 (12): 1115-1121.
Zerón A. Genoma, microbioma y epigenoma humano. Una visión contemporánea de la triada ecológica. Rev ADM. 2014; 71 (4): 162-170.
Zerón A. Biotipos, fenotipos y genotipos ¿De qué tipo somos? Rev Mex Periodontol. 2010; 1 (1): 36-43.
Tsuchida S, Satoh M, Umemura H et al. Proteomic analysis of gingival crevicular fluid for discovery of novel periodontal disease markers. Proteomics. 2012; 12: 2190-2202.
Wilson AG. Epigenetic regulation of gene expression in the inflammatory response and relevance to common diseases. J Periodontol. 2008; 79 (Suppl. 8): 1514-1519.
Roshandel D, Holliday KL, Pye SR et al; EMAS Study Group. Genetic variation in the RANKL/RANK/OPG signaling pathway is associated with bone turnover and bone mineral density in men. J Bone Miner Res. 2010; 25: 1830-1838.
Schafer AS, Jepsen S, Loos BG. Periodontal genetics: a decade of genetic association studies mandates better study designs. J Clin Periodontol. 2011; 38: 103-107.
Shimizu S, Momozawa Y, Takahashi A, Nagasawa T, Ashikawa K, Terada Y et al. A genome-wide association study of periodontitis in a Japanese population. J Dent Res. 2015; 94 (4): 555-561.
Mathers JC, Strathdee G, Relton CL. Induction of epigenetic alterations by dietary and other environ-mental factors. Adv Genet. 2010; 71: 3-39.
Zerón A. Medicina periodontal. Capítulo 2. En: Castellanos-Suárez J, Díaz-Guzmán L, Gay-Zárate O. Medicina en odontología. 3a ed. México: El Manual Moderno; 2014.