Méndez-Navarro J, Ortiz-Olvera NX, Villegas-Ríos M, Méndez-Tovar LJ, Andersson KL, Moreno-Alcantar R, Gallardo-Cabrera VE, Félix S, Galván C, Vargas G, Gómez LM, Dehesa-Violante M

Language: Spanish
References: 58
Page: 568-574
PDF size: 1096.47 Kb.

ABSTRACT

We present two cases of acute liver injury resulting from consumption of wild mushrooms. The first case was a male who developed acute hepatitis after ingestion of diverse mushrooms including Amanita species. His clinical course was favorable with complete recovery of liver function. The second case was a male who developed acute liver failure (ALF) after ingestion of Amanita bisporigera. He required MARS therapy as a bridge to liver transplantation but transplantation was not performed because he succumbed to multiorgan failure. There are few trials demonstrating the efficacy of the different treatments for mushroom poisoning. These cases demonstrate that the consumption of wild mushrooms without proper knowledge of toxic species represents a serious and under recognized health problem.

REFERENCES

1. Magdalan J, Ostrowska A, Piotrowska A, et al. α-Amanitin induced apoptosis in primary cultured dog hepatocytes. Folia Histo Et Cytobiologica 2010; 48: 58-62.

2. Li Chen, Oberlies NH. The most widely recognized mushroom: chemistry of the genus Amanita. Life Sciences 2005; 78: 532-8.

3. Tulloss RE, Ovrebo CL, Halling RE. Studies on Amanita (Agaricales) from Andean Colombia. Mem New York Bot Gard 1992; 66: 1-46.

4. Diaz JH. Syndromic diagnosis and management of confirmed mushroom poisonings. Crit Care Med 2005; 33: 427-36.

5. Benjamin DR. Mushrooms: poisons and panaceas. New York, USA: WH Freeman and Company; 1995.

6. Pringle A, Adams RI, Cross HB, Bruns TD. The ectomycorrhizal fungus Amanita phalloides was introduced and is expanding its range on the west coast of North America. Mol Ecol 2009; 18: 817-33.

7. Karlson-Stiber C, Persson H. Cytotoxic fungi-an overview. Toxicon 2003; 42: 339-49.

8. Jiménez-Escobar I, Flores-Nava G, Vazquez-Zavala G, Alba-Palacios RA, Lavalle-Villalobos A. Hepatopatía por ingestión de hongos silvestres. Presentación de dos casos. Rev Mex Pediatr 2005; 72: 27-30.

9. Madhok M, Scalzo A, Blume C, Neuschwander-Tetri BA, Weber JA, Thompson MW. Amanita Bisporigera Ingestion. Mistaken identity, dose-related toxicity and improvement despite severe hepatotoxicity. Pediatric Emergency care 2006; 22: 177-80.

10. Krenova M, Pelclova D, Navratil T. Survey of Amanita phalloides poisoning: clinical findings and follow-up evaluation. Human & Experim Toxicol 2007; 26: 955-61.

11. Hallen HE, Luo H, Scott-Craig JS, Walton JD. Gene family encoding the major toxins of lethal Amanita mushrooms. PNAS 2007; 104: 19097-101.

12. Vetter J, Toxins of Amanita phalloides. Toxicon 1998; 36: 13-24.

13. Enjalbert F, Cassanas G, Salhi SL, Guinchard C, Chaumont JP. Distribution of the amatoxins and phallotoxins in Amanita phalloides. Influence of the tissues and collection site. CR Acad Sci III 1999; 322: 855-62.

14. Yildiz BD, Abbasoglu O, Saglam A, Sokmensüer C. Urgent liver transplantation for Amanita phalloides poisoning. Pediatr Transplant 2008; 12: 105-8.

15. Zheleva A, Tolekova A, Zhelev M, Uzunova V, Platikanova M, Gadzheva V. Free radical reactions might contribute to severe alpha amanitin hepatotoxicity-a hypothesis. Med Hypotheses 2007; 69: 361-7.

16. Escudié L, Francoz C, Vinel J-P, et al. Amanita phalloides poisoning: Reassessment of prognostic factors and indications for emergency liver transplantation. J Hepatol 2007; 46: 466-73.

17. Broussard CN, Aggarwal A, Lacey SR, et al. Mushroom poisoning- from diarrhea to liver transplantation. Am J Gastroenterol 2001; 96: 3195-8.

18. Kucuk HF, Karasu M, Kilic M, Nart D. Liver failure in transplanted liver due to Amanita Falloides. Transplant Proceed 2005; 37: 2224-6.

19. Mas A. Mushrooms, amatoxins and the liver. J Hepatol 2005; 42: 166-9.

20. Jander S, Bischoff J, Woodcock BG. Plasmapheresis in the treatment of amanita phalloides poisoning: II. A review and recommendations. Ther Apher 2000; 4: 308-12.

21. Ganzert M, Felgenhauer N, Zilker T. Indication of liver transplantation following amatoxin intoxication. J Hepatol 2005; 42: 202-9.

22. Rainone F. Milk Thistle. Am Fam Physician 2005; 72: 1285-8.

23. Perez-Gordillo JH, Colbert-Rodriguez M, Cruz Rivera N, Perez Gordillo G. Falla hepática fulminante por intoxicación por Amanita verna. Reporte de tres casos. Rev Hosp Jua Mex 2009; 76: 168-75.

24. Faybik P, Hetz H, Baker A, et al. Extracorporeal albumin dialysis in patients with amanita phalloides poisoning. Liver Intern 2003; 23: 28-33.

25. Shi Y, He J, Chen S, et al. MARS: optimistic therapy method in fulminant hepatic failure secondary to cytotoxic mush-room poisoning-a case report. Liver 2002; 22: 78-80.

26. Montalti R, Nardo B, Beltempo P, Bertelli, Puviani L, Cavallari A. Liver transplantation in fulminant hepatic failure: Experience with 40 adult patients over a 17-year period. Transplant Proceed 2005; 37: 1085-7.

27. Panaro F, Andorno E, Morelli N, et al. Liver transplantation represents the optimal treatment for fulminant hepatic failure from amanita phalloides poisoning. Europ Soc Organ Transplant 2006; 19: 344-5.

28. Garibay-Orijel R, Cifuentes J, Estrada-Torres A, Caballero J. People using macro-fungal diversity in Oaxaca, Mexico. Fungal Divers 2006; 21: 41-67.

29. Montoya A, Kong A, Estrada-Torres A, Cifuentes J. Caballero J. Useful wild fungi of La Malinche Nacional Park, Mexico. Fungal Divers 2004; 17: 115-43.

30. Magdalan J, Ostrowska A, Piotrowska A, et al. α-Amanitin induced apoptosis in primary cultured dog hepatocytes. Folia Histo Et Cytobiologica 2010; 48: 58-62.

31. Li Chen, Oberlies NH. The most widely recognized mushroom: chemistry of the genus Amanita. Life Sciences 2005; 78: 532-8.

32. Tulloss RE, Ovrebo CL, Halling RE. Studies on Amanita (Agaricales) from Andean Colombia. Mem New York Bot Gard 1992; 66: 1-46.

33. Diaz JH. Syndromic diagnosis and management of confirmed mushroom poisonings. Crit Care Med 2005; 33: 427-36.

34. Benjamin DR. Mushrooms: poisons and panaceas. New York, USA: WH Freeman and Company; 1995.

35. Pringle A, Adams RI, Cross HB, Bruns TD. The ectomycorrhizal fungus Amanita phalloides was introduced and is expanding its range on the west coast of North America. Mol Ecol 2009; 18: 817-33.

36. Karlson-Stiber C, Persson H. Cytotoxic fungi-an overview. Toxicon 2003; 42: 339-49.

37. Jiménez-Escobar I, Flores-Nava G, Vazquez-Zavala G, Alba-Palacios RA, Lavalle-Villalobos A. Hepatopatía por ingestión de hongos silvestres. Presentación de dos casos. Rev Mex Pediatr 2005; 72: 27-30.

38. Madhok M, Scalzo A, Blume C, Neuschwander-Tetri BA, Weber JA, Thompson MW. Amanita Bisporigera Ingestion. Mistaken identity, dose-related toxicity and improvement despite severe hepatotoxicity. Pediatric Emergency care 2006; 22: 177-80.

39. Krenova M, Pelclova D, Navratil T. Survey of Amanita phalloides poisoning: clinical findings and follow-up evaluation. Human & Experim Toxicol 2007; 26: 955-61.

40. Hallen HE, Luo H, Scott-Craig JS, Walton JD. Gene family encoding the major toxins of lethal Amanita mushrooms. PNAS 2007; 104: 19097-101.

41. Vetter J, Toxins of Amanita phalloides. Toxicon 1998; 36: 13-24.

42. Enjalbert F, Cassanas G, Salhi SL, Guinchard C, Chaumont JP. Distribution of the amatoxins and phallotoxins in Amanita phalloides. Influence of the tissues and collection site. CR Acad Sci III 1999; 322: 855-62.

43. Yildiz BD, Abbasoglu O, Saglam A, Sokmensüer C. Urgent liver transplantation for Amanita phalloides poisoning. Pediatr Transplant 2008; 12: 105-8.

44. Zheleva A, Tolekova A, Zhelev M, Uzunova V, Platikanova M, Gadzheva V. Free radical reactions might contribute to severe alpha amanitin hepatotoxicity-a hypothesis. Med Hypotheses 2007; 69: 361-7.

45. Escudié L, Francoz C, Vinel J-P, et al. Amanita phalloides poisoning: Reassessment of prognostic factors and indications for emergency liver transplantation. J Hepatol 2007; 46: 466-73.

46. Broussard CN, Aggarwal A, Lacey SR, et al. Mushroom poisoning- from diarrhea to liver transplantation. Am J Gastroenterol 2001; 96: 3195-8.

47. Kucuk HF, Karasu M, Kilic M, Nart D. Liver failure in transplanted liver due to Amanita Falloides. Transplant Proceed 2005; 37: 2224-6.

48. Mas A. Mushrooms, amatoxins and the liver. J Hepatol 2005; 42: 166-9.

49. Jander S, Bischoff J, Woodcock BG. Plasmapheresis in the treatment of amanita phalloides poisoning: II. A review and recommendations. Ther Apher 2000; 4: 308-12.

50. Ganzert M, Felgenhauer N, Zilker T. Indication of liver transplantation following amatoxin intoxication. J Hepatol 2005; 42: 202-9.

51. Rainone F. Milk Thistle. Am Fam Physician 2005; 72: 1285-8.

52. Perez-Gordillo JH, Colbert-Rodriguez M, Cruz Rivera N, Perez Gordillo G. Falla hepática fulminante por intoxicación por Amanita verna. Reporte de tres casos. Rev Hosp Jua Mex 2009; 76: 168-75.

53. Faybik P, Hetz H, Baker A, et al. Extracorporeal albumin dialysis in patients with amanita phalloides poisoning. Liver Intern 2003; 23: 28-33.

54. Shi Y, He J, Chen S, et al. MARS: optimistic therapy method in fulminant hepatic failure secondary to cytotoxic mush-room poisoning-a case report. Liver 2002; 22: 78-80.

55. Montalti R, Nardo B, Beltempo P, Bertelli, Puviani L, Cavallari A. Liver transplantation in fulminant hepatic failure: Experience with 40 adult patients over a 17-year period. Transplant Proceed 2005; 37: 1085-7.

56. Panaro F, Andorno E, Morelli N, et al. Liver transplantation represents the optimal treatment for fulminant hepatic failure from amanita phalloides poisoning. Europ Soc Organ Transplant 2006; 19: 344-5.

57. Garibay-Orijel R, Cifuentes J, Estrada-Torres A, Caballero J. People using macro-fungal diversity in Oaxaca, Mexico. Fungal Divers 2006; 21: 41-67.

58. Montoya A, Kong A, Estrada-Torres A, Cifuentes J. Caballero J. Useful wild fungi of La Malinche Nacional Park, Mexico. Fungal Divers 2004; 17: 115-43.