Piñol JFN, González FL, Ikehara HMJ, Galainiega J, Morera PM, Vegas SA

Language: Spanish
References: 23
Page: 333-341
PDF size: 128.91 Kb.

ABSTRACT

Introduction: the adenoma-adenocarcinoma sequence is a result of inherited or acquired genetic failures in the intestinal cells.
Objective: to determine the immunohistochemical expression of p53 and the positivity of the fecal occult blood test in colon adenomas with high degree of diagnosed dysplasia in cholecystectomized patients or with cholelithiasis.
Methods: descriptive, cross-sectional study conducted in the Institute of Gastroenterology in the period of May, 2013 to June, 2015. Statistical tests were statistics testing, exact Chi Square and Fisher's probability tests.
Results: the proportion of adenomas with high degree of dysplasia was similar in cholecystectomized patientsand with cholelithiasis (50 %) respectively. A high proportion diagnosed in colecistectomizados women (35 %), 60 and more years of age (53 %) and 11 and more years of performed cholecystectomy (60 %), whereas cholelithiasis prevailed in males (30 %).
Conclusions: high proportion of adenomas with high degree of dysplasia present p 53 immunoexpression and positive fecal occult blood test in cholecystectomized patients and patients with cholelithiasis that is reported for the first time.

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