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2015, Number 2

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RCAN 2015; 25 (2)

Impact of the use of probiotics upon selected indicators of the nutritional status of the hospitalized patient

Pedroso GT, Agramonte PG, Montano HI, Guedes RD, García MI

Language: Spanish
References: 49
Page: 261-275
PDF size: 473.39 Kb.


ABSTRACT

Rationale: The use of probiotics might be useful for nutritional and clinical recovery of the patient at risk of malnutrition and immune depression as consequence of the response to the medical-surgical treatment. Study design: Quasi-experimental study for assessing the effectiveness as a bacterial interference therapy for the restoration of the intestinal ecosystem and the nutritional status of the patient of a yogurt incorporating selected, viable probiotics (Therapy A) vs. another one with a regular bacterial composition (Therapy B). Study location: “Luis Díaz Soto” Hospital (Havana City, Cuba). Study serie: Seventy-three patients (Males: 58.9%; Ages ≥ 60 years: 46.6%) assisted at the institution between June 2011 and June 2012 (both included) in whom systemic sepsis, bacterial overgrowth and diarrhea associated with prolonged antibiotic therapy, and failure of healing causing anastomosis dehiscence and surgical wound sepsis concurred. Material and method: Patients were assigned randomly to one of each therapy: Therapy A: 52.1% vs. Therapy B: 47.9%. Therapeutic effectiveness was measured from change in anthropometric and biochemical indicators of nutritional status after 7 days (at least) of treatment with 750 milliliters of the yogurt (250 milliliters every 8 hours). Additional treatment cycles were prescribed according with the patient´s response. Results: Sixteen-pointnine days of treatment per patient were completed (Therapy A: 17.1 ± 12.9 vs. Therapy B: 16.5 ± 13.1; p › 0.05). Daily energy intakes were independent from the assigned treatment: Therapy A: 2,213.4 ± 751.1 Kcal.24 hours-1 vs. Therapy B: 2,250.6 ± 705.4 Kcal.24 hours-1 (t = -0.217; p › 0.05; test for comparing independent means). Adverse reaction rate (manifesting as diarrhea) was 2.7%. Microbial interference therapy only resulted in an increase of serum cholesterol basal values: Therapy A: +0.2 ± 0.9 mmol.L-1 vs. Therapy B: -0.14 ± 0.9 mmol.L-1 (p ‹ 0.05). Conclusions: Microbial interference therapy with probiotics provided as a yogurt can cause increases in serum total cholesterol. If the change observed in this nutritional indicator represents a better prognosis for the patient remains to be proved.


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