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ISSN 1527-3172 (Electronic)

2013, Number 1

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MEDICC Review 2013; 15 (1)

Evidence of association between Type 1 diabetes and exposure to enterovirus in Cuban children and adolescents

Sarmiento L, Cubas-Dueñas I, Cabrera-Rode E

Language: English
References: 31
Page: 29-32
PDF size: 151.90 Kb.


ABSTRACT

A possible etiologic role of enteroviruses for type 1 diabetes has been researched for 40 years, but evidence to date is inconclusive. This article summarizes new evidence from Cuban research supporting a role for enteroviruses, both in preclinical stages of autoimmune reactions against pancreatic β cells and at clinical onset, in a population with low type 1 diabetes incidence. Possible pathogenetic mechanisms are also discussed, such as acute cytolytic damage and molecular mimicry. Although direct causal effects of enteroviruses in type 1 diabetes are difficult to demonstrate, arguments supporting their role in type 1 diabetes pathogenesis should not be ignored; and confirmation could contribute to development of more effective preventive strategies.


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