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2015, Number 6

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Revista Habanera de Ciencias Médicas 2015; 14 (6)

Occult infection and viral co-infection in chronic hepatitis B patients

La Rosa HD, Vega SH, Sánchez CN, Martínez PY, Santos HN, Arús FAE, Verdecia MP, Sayú CP, Gómez CEJ

Language: Spanish
References: 20
Page: 737-746
PDF size: 144.49 Kb.


ABSTRACT

Introduction:> infection with the hepatitis B virus is one of the major health problems worldwide, clinical spectrum is variable.
Objective: to identify occult viral infection and co-infection in patients with chronic liver disease for virus B.
Material and Methods: a cross-sectional observational study was conducted in patients with chronic hepatitis B with detectable viral load seen during the last quarter of 2014 in the Institute of Gastroenterology. The seroprevalence of anti HCV and anti HIV and the frequency of HBsAg and Anti S was estimated associations were evaluated using the x2 statistic.
Results: there is a predominance of low viral loadsto81.3%. 28.7% of samples were HBsAg negative, suggestive of occult virus infection. Protective levels against the antigen S were detected in 20% of patients with low viral load.Hepatitis C coinfection was frequent for 8.4%.
Conclusions: the occult infection hepatitis B virus is common in samples processed at the Institute of Gastroenterology with associated coinfection virus hepatitis C.


REFERENCES

  1. Gerlich WH. Medical virology of hepatitis B: how it began and where we are now. Virology journal. 2013;10:239.

  2. Niederau C. Chronic hepatitis B in 2014: great therapeutic progress, large diagnostic deficit. World journal of gastroenterology : WJG. 2014;20(33):11595.

  3. Pourkarim MR, Amini-Bavil-Olyaee S, Kurbanov F, Van Ranst M, Tacke F. Molecular identification of hepatitis B virus genotypes/subgenotypes: revised classification hurdles and updated resolutions. World journal of gastroenterology : WJG. 2014;20(23):7152-68.

  4. Alavian SM, Miri SM, Hollinger FB, Jazayeri SM. Occult Hepatitis B (OBH) in Clinical Settings. Hepatitis monthly. 2012;12(8):e6126.

  5. Lledo JL, Fernández C, Gutiérrez ML, Ocana S. Management of occult hepatitis B virus infection: an update for the clinician. World journal of gastroenterology : WJG. 2011;17(12):1563-8.

  6. Raimondo G, Caccamo G, Filomia R, Pollicino T. Occult HBV infection. Seminars in immunopathology. 2013;35(1):39-52.

  7. Said ZN. An overview of occult hepatitis B virus infection. World journal of gastroenterology : WJG. 2011;17(15):1927-38.

  8. Samal J, Kandpal M, Vivekanandan P. Molecular mechanisms underlying occult hepatitis B virus infection. Clinical microbiology reviews. 2012;25(1):142-63.

  9. Schmeltzer P, Sherman KE. Occult hepatitis B: clinical implications and treatment decisions. Digestive diseases and sciences. 2010;55(12):3328-35.

  10. Fernández-Rodríguez CM, Gutiérrez ML, Lledo JL, Casas ML.Influence of occult hepatitis B virus infection in chronic hepatitis C outcomes. World journal of gastroenterology : WJG. 2011;17(12):1558-62.

  11. Ferrari TC, Xavier MA, Vidigal PV, Amaral NS, Diniz PA, Resende AP, et al. Occult hepatitis B virus infection in liver transplant patients in a Brazilian referral center. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica [et al]. 2014;47(11):990-4.

  12. Habibollahi P, Safari S, Daryani NE, Alavian SM. Occult hepatitis B infection and its possible impact on chronic hepatitis C virus infection. Saudi journal of gastroenterology: official journal of the Saudi Gastroenterology Association. 2009;15(4):220-4.

  13. Maldonado-Rodríguez A, Cevallos AM, Rojas-Montes O, Enriquez-Navarro K, Álvarez-Muñoz MT, Lira R. Occult hepatitis B virus co-infection in human immunodeficiency virus-positive patients: A review of prevalence, diagnosis and clinical significance. World journal of hepatology. 2015;7(2):253-60.

  14. De la Fuente RA, Gutiérrez ML, García-Samaniego J, Fernández-Rodríguez C, Lledo JL, Castellanos G. Pathogenesis of occult chronic hepatitis B virus infection. World journal of gastroenterology : WJG. 2011;17(12):1543-8. Epub 2011/04/08.

  15. World Medical Association Declaration of Helsinki. Ethical principles for medical research involving human subjects.WMA. 2013.

  16. Ministerio de Salud Pública. Anuario Estadístico de Salud. Cuadro 66. 2014:90-1.

  17. Hernández CM, Folgueira RM, Cendán A,Turcaz N. Prevalencia de hepatiris virales B y C en trabajadores del Intituto de Gastroenterología de La Habana. Revista Cubana de Salud y Trabajo. 2014;15(3):24-30.

  18. Rios-Ocampo WA, Cortes-Mancera F, Olarte JC, Soto A, Navas MC.Occult hepatitis B virus infection among blood donors in Colombia. Virology journal. 2014;11:206.

  19. Sagnelli E, Pisaturo M, Martini S, Filippini P, Sagnelli C, Coppola N. Clinical impact of occult hepatitis B virus infection in immunosuppressed patients. World journal of hepatology. 2014;6(6):384-93.

  20. Tramuto F, Maida CM, Colomba GM, Di Carlo P, Vitale F. Prevalence of occult hepatitis B virus infection in a cohort of HIV-positive patients resident in Sicily, Italy.Biomed Res Int. 2013.




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