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Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

2015, Number 4

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Rev Invest Clin 2015; 67 (4)

Surveillance of Oseltamivir-Resistant Influenza A(H1N1)pdm09 in Guanajuato State, Mexico from 2009 to 2012

Mosqueda-Gómez JL, Belaunzarán-Zamudio PF, Barba A, Córdova-Villalobos JA, Cuellar-Rodríguez JM, Macías AE

Language: English
References: 19
Page: 235-239
PDF size: 225.71 Kb.


ABSTRACT

Background: The influenza A(H1N1)pdm09 virus was first identified in Mexico in April 2009, subsequently spreading worldwide. Soon after the WHO declared a pandemic, a series of cases involving oseltamivir-resistant viruses were described, following concerns about the spread of strains resistant to neuraminidase inhibitors that could hamper control measures. To study the prevalence of oseltamivir-resistant influenza A(H1N1)pdm09, we implemented a surveillance program across the state of Guanajuato, Mexico. Methods: We collected respiratory samples from patients with confirmed infection with influenza A(H1N1) pdm09 virus between 2009 and 2012 in rural and urban regions in Guanajuato, Mexico. Specimens were screened for the H275Y mutation by Sanger sequencing. Results: A total of 1,192 laboratory confirmed influenza A(H1N1)pdm09-positive samples were processed between 2009 and 2012. Using two endpoint real-time polymerase chain reaction, 575 samples were sequenced. Two different clusters, I and II, were identified. The H275Y substitution was found in only one sample from cluster I. Conclusions: The prevalence of oseltamivir-resistant influenza A(H1N1)pdm09 2009 viruses during the pandemic period and following years was very low in our State.


REFERENCES

  1. Centers for Disease Control and Prevention. Update: swine influenza A (H1N1) infections - California and Texas, April 2009. MMWR Morb Mortal Wkly Rep. 2009;58:435-7.

  2. Shaw MW, Lindstrom S, Garten RJ, et al. Novel Swine-Origin Influenza A (H1N1) Virus Investigation Team. Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N Engl J Med. 2009;360:2605-15.

  3. Smith GJ, Vijaykrishna D, Bahl J, et al. Origins and evolutionary genomics of the 2009 swine - origin H1N1 influenza A epidemic. Nature. 2009;459:1122-5.

  4. Pérez-Padilla R, de la Rosa-Zamboni D, Ponce de León S, et al. Pneumonia and respiratory failure from swine-origin influenza A (H1N1) in Mexico. N Engl J Med. 2009;361:680-9.

  5. World Health Organization. Pandemic (H1N1) 2009—update 101. Weekly update [cited 2010 May 21]. Available at: http:// www.who.int/csr/ don/2010_05_21/en/index.html

  6. Updated interim recommendations for the use of antiviral medications in the treatment and prevention of influenza for the 2009-2010 season. Atlanta: Centers for Disease Control and Prevention. Available at: http://www.cdc.gov/h1n1flu/recommendations. htm. [Accessed February 2013].

  7. Le QM, Wertheim HF, Tran ND, van Doorn HR, Nguyen TH, Horby P; Vietnam H1N1 Investigation Team. A community cluster of oseltamivir-resistant cases of 2009 H1N1 influenza. N Engl J Med. 2010;362:86-7.

  8. Baz M, Abed Y, Papenburg J, Bouhy X, Hamelin ME, Boivin G. Emergence of oseltamivir-resistant pandemic H1N1 virus during prophylaxis. N Engl J Med. 2009;361:2296-7.

  9. Dharan NJ, Gubareva LV, Meyer JJ, et al. Infections with oseltamivir- resistant influenza A(H1N1) virus in the United States. JAMA. 2009;301:1034-41.

  10. Sheu TG, Deyde VM, Okomo-Adhiambo M, et al. Surveillance for neuraminidase inhibitor resistance among human influenza A and B viruses circulating worldwide from 2004 to 2008. Antimicrob Agents Chemother. 2008;52:3284-92.

  11. Dirección General de Epidemiología, Secretaría de Salud, México. Influenza. Documento Técnico. Updated: February 5th, 2014. Mexico 2014. Available at: http://www.epidemiologia.salud.gob.mx/ doctos/lineamientos/influenza/documento_tecnico_influenza.pdf

  12. Grupo Técnico Interinstitucional del Comité Nacional para la Vigilancia Epidemiológica (CONAVE). Lineamientos para la Vigilancia Epidemiológica de Influenza. Published: January 2012. Available at: http://www.ssm.gob.mx/portal/page/influenza/ LINEAMIENTOS%20DE%20INFLUENZA.pdf

  13. Centers for Disease Control and Prevention. CDC realtime RTPCR (rRTPCR) protocol for detection and characterization of swine influenza (version 2009). Ref. no. I-007–05. Atlanta: The Centers; 2009.

  14. Ramírez-González JE, González-Durán E, Alcántara-Pérez P, et al. Oseltamivir-resistant pandemic (H1N1) 2009 virus, Mexico. Emerg Infect Dis. 2011;17:283-6.

  15. Whitley RJ, Boucher CA, Lina B, et al. Global assessment of resistance to neuraminidase inhibitors, 2008–2011: The Influenza Resistance Information Study (IRIS). Clin Infec Dis. 2013;56:1197-205.

  16. de la Rosa-Zamboni D, Vázquez-Pérez JA, Avila-Ríos S, et al. Molecular characterization of the predominant influenza A(H1N1) pdm09 virus in Mexico, December 2011-February 2012. PLoS One. 2012;7:e50116.

  17. Lopes e Souza TM, Fintelman-Rodrigues N, Resende PC, et al. Oseltamivir-resistant influenza A(H1N1)pdm2009 strains found in Brazil are endowed with permissive mutations, which compensate the loss of fitness imposed by antiviral resistance. Mem Inst Oswaldo Cruz. 2015;110:101-5.

  18. Valenzuela MT, de Quadros C. Antibiotic resistance in Latin America: A cause for alarm. Vaccine. 2009;27(Suppl 3):S25-8.

  19. Gutiérrez-Mendoza LM, Schwartz B, Méndez de Lira J, Wirtz VJ. Oseltamivir storage, distribution and dispensing following the 2009 H1N1 influenza outbreak in Mexico. Bull World Health Organ 2012;90:782-7.




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