Polymorphism P.D1134a of the TJP1 in population with Zapotec ancestry: A marker for potential thyroid cancer and other neoplasms

Perla Madrigal-Ruiz; Nory Omayra Dávalos- Rodríguez; Sergio Alberto Ramírez-García; Luz Rosalba Topete-González; Manuel Mazariegos-Rubi; Luis J Flores-Alvarado; Rosalba Ruiz-Mejía; Ma E Aguilar-Aldrete; José de Jesús Magallanes-Ordoñez; Lorena Guadalupe Ramón-Canul; José Isaías Siliceo-Murrieta; Guilibaldo Gabriel Zurita-Vásquez; Jareth Marco Cruz-Bastida

2015, Number 1

Rev Med MD 2015; 6.7 (1)

**Polymorphism P.D1134a of the TJP1 in population with Zapotec ancestry: A marker for potential thyroid cancer and other neoplasms**

Madrigal-Ruiz P, Dávalos-Rodríguez NO, Ramirez-Garcia SA, Topete-González LR, Mazariegos-Rubi M, Flores-Alvarado LJ, Ruiz-Mejia R, Aguilar-Aldrete ME, Magallanes-Ordoñez JJ, Ramón-Canul LG, Siliceo-Murrieta JI, Zurita-Vásquez GG, Cruz-Bastida JM

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ABSTRACT

Introduction. TJP1 gene encodes protein ZO-1, that is required for the recruitment of occludins and claudins in tight junctions involved in cell polarization. It has different variations that have been studied in several populations. There are no studies regarding this gene in Mexico. It is necessary to continue investigation because its polymorphisms may be used in association studies for thyroid cancer and other neoplasms. Considering its expression level, an increase in ZO-1 has been demonstrated in thyroid medullar cancer. The objective of this study is to estimate the frequency of genotypes and alleles of polymorphism rs 2291166 (p.D1134A) in gene TJP1 among Mexican population with Zapotec ancestry.
Material and Methods. 159 individuals with Zapotec ancestry were included. The polymorphism was identified by PCR-PASA and electrophoresis PAGE 7%..
Results. The most frequent allele in both populations was ancestral allele (T), as in other populations. The polymorphism is in Hardy-Weinberg equilibrium among the population analyzed (p ›0.05).
Discussion. SNP rs2291166 is a polymorphic marker in Mexican population and it may be used in association studies regarding thyroid carcinogenesis.

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