González-Ramírez MP, Miravete-Lagunes K, Gómez-de-León A, Poncede-León S, Tenorio-Rojo AP, Martagón-Herrera NA, Hernández-Reyes JA, García-Villasenor A, Burguette E, Vallejo-Villalobos MF, Ruiz-Delgado GJ, Gómez-Almaguer D, Ruiz-Argüelles GJ

Language: English
References: 17
Page: 109-116
PDF size: 185.08 Kb.

ABSTRACT

Background: Quality of life (QOL) is an important consideration in the counseling, implementation, and post-treatment management of arduous treatments for life-threatening conditions such as allogeneic hematopoietic cell transplantation (allo-HCT). Objective: To analyze the QOL of leukemia patients allografted with the Mexican reduced-intensity conditioning regimen in two Mexican academic medical centers. Material and methods: By means of the quality metric short form 36 version 2 to measure generic health concepts, relevant QOL was analyzed in leukemia patients who underwent allo-HCT using reducedintensity conditioning on an outpatient basis at either the Centro de Hematología y Medicina Interna de Puebla of the Clínica Ruiz or the Hematology Service of the Internal Medicine Department of the Hospital “Dr. José Eleuterio González” of the Universidad Autónoma de Nuevo León, and who had survived more than 12 months after the allograft, who could be approached, who were in a continued complete remission (with or without graft-versus-host disease), and who were willing to respond to the questionnaire. Thirty-five patients fulfilling these requirements were included, and a sex- and age-matched group of 35 reference subjects was also studied. Results: Allografted patients were found to have a slightly better mental component summary than the reference subjects (53.23 vs. 48.66 points; p = 0.01), whereas the physical component summary did not show a difference (54.53 vs. 52.05 points; p = 0.59). Most of the differences between allografted individuals and reference subject controls were not significant. Conclusions: Despite several sources of bias, these data suggest that allografted individuals employing the Mexican reduced-intensity conditioning regimen enjoy a health-related QOL life similar to that of reference subjects, adding another advantage of this method of conducting stem cell allografts. However, more work needs to be done to elucidate the impact of reduced-intensity conditioning on post allo-HCT QOL.

REFERENCES

1. Pîdala J, Anasetti C, Jim H. Quality of life after hematopoietic cell transplantation. Blood. 2009;114:7-19.

2. Cantú-Rodriguez OG, Gutiérrez-Aguirre CH, Jaime-Pérez JC, et al. Low incidence and severity of graft-versus-host disease after outpatient allogeneic peripheral blood stem cell transplantation employing a reduced-intensity conditioning. Eur J Haematol. 2011;87;521-30.

3. Gómez-Almaguer D, Ruiz-Argüelles GJ, Ruiz-Argüelles A, González- Llano O, Cantú OE, Hernández NE. Hematopoietic stem cell allografts using a non-myeloablative conditioning regimen can be safely performed on an outpatient basis. Bone Marrow Transpl. 2000;25:131-3.

4. Syrjala KL, Langer SL, Abrams JR, Storer BE, Martin PJ. Late effects of hematopoietic stem cell transplantation among 10-year adult survivors compared with case-matched controls. J Clin Oncol. 2005;23:6596-606.

5. Cantú-Rodriguez OG, Jaime-Perez JC, Gutiérrez-Aguirre CH, et al. Outpatient allografting using non-myeloablative conditioning: the Mexican experience. Bone Marrow Transplant. 2007;40:119-23.

6. Ruiz-Delgado GJ, Ruiz-Argüelles GJ. A Mexican way to cope with stem cell transplantation. Hematology. 2012;17(Suppl 1):195-7.

7. Pollack SM, O’Connor TP, Hashash J, Tabbara IA. Nonmyeloablative and reduced-intensity conditioning for allogeneic hematopoietic stem cell transplantation: a clinical review. Am J Clin Oncol. 2009;32:618-28.

8. Ruiz-Argüelles GJ, Gómez-Almaguer D. Editorial: Allografting on outpatient basis can decrease GVHD prevalence, severity. Hem Onc Today. 2012;13:8.

9. Ruiz-Argüelles GJ, Gómez-Almaguer D. Nephrotic syndrome after non-myeloablative stem cell transplantation. Brit J Haematol. 2006;132:801-2.

10. Ruiz-Argüelles GJ, Gómez-Almaguer D, López-Martínez B, Ponce- De-León S, Cantú-Rodriguez OG, Jaime-Pérez JC. No cytomegalovirus- related deaths after non-ablative stem cell allografts. Hematolog. 2002;7:95-9.

11. Ruiz-Argüelles GJ, Gómez-Rangel JD, Ponce-de-León S, González- Déctor L, Reyes-Núñez V, Garcés-Eisele J. The Mexican schedule to conduct allogeneic stem cell transplantation is related to a low risk of cytomegalovirus reactivation and disease. Am J Hematol. 2004;75;200-4.

12. Ruiz-Argüelles GJ, Gómez-Almaguer D, Steensma DP. Outdated dogma?: Busulfan, seizure prophylaxis and stem cell allografting. Am J Hematol. 2012;87:941.

13. Zamora-Ortiz G, Velázquez-Sánchez-de-Cima S, Ponce-de-León S, et al. Secondary malignancies after allogeneic hematopoietic stem cell transplantation using reduced-intensity conditioning and outpatient conduction. Hematology. 2014;19:435-40.

14. Wong R, Giralt SA, Martin T, et al. Reduced intensity conditioning for unrelated donor hematopoietic stem cell transplantation as treatment for myeloid malignancies in patients older than 55 years. Blood. 2003;102:3052-9.

15. Bevans MF, Marden S, Leidy NK, et al. Health related quality of life in patients receiving reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant. 2004;34:729-38.

16. Díez-Campelo M, Pérez-Simón JA, González-Porras JR, et al. Quality of life assessment in patients undergoing reduced intensity conditioning allogeneic as compare to autologous transplantation: Results of a prospective study. Bone Marrow Transplant. 2004;34:729-38.

17. Leunis A, Ken Redekop W, Uyl-de Groot CA, Lowenberg B. Impaired health-related quality of life in acute myeloid leukemia survivors: A single-center study. Eur J Haematol. 2014;93:198-206.