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2015, Number 2

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Rev Med UV 2015; 15 (2)

Phenolphthalein-based laxatives and its relation to cancer development

Herrera-Covarrubias D, Fernández-Pomares C, Coria-Ávila GA, Manzo DJ, Aranda-Abreu GE, Hernández AME

Language: Spanish
References: 56
Page: 91-101
PDF size: 404.38 Kb.


ABSTRACT

Laxatives are substances prescribed to treat constipation. Their effect on defecation is produced by either chemical stimulation of the digestive tract motility, or lubrication of the stools. Phenolphthalein is a laxative that some studies associate with intestinal paralysis, electrolyte disturbances, hemorrhoids, loss of bowel function, pancreatitis and the development of various types of cancer. In this review we report literature related to the prolonged abuse of laxatives containing phenolphthalein and its relation to the development of cancer. The results of the literature suggest that long term abuse of phenolphthalein-based laxatives should be considered a risk factor in cancer development. Such evidence is clearer in animal models and in vitro studies as compared to humans. Further studies are required to determine its carcinogenic mechanisms.


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