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Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

2005, Number 2

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Rev Invest Clin 2005; 57 (2)

Pediatric liver transplantation

Varela-Fascinetto G, Dávila-Pérez R, Hernández PA, Castañeda-Martínez P, Fuentes-García V, Nieto ZJ

Language: Spanish
References: 47
Page: 273-282
PDF size: 79.74 Kb.


ABSTRACT

Pediatric liver transplantation has evolved over the last two decades into an effective and widely accepted therapy for infants and children. Currently, these high-risk patients achieve 85 to 90% one-year patient survival and an excellent quality of life. This paper reviews the special features of the pediatric recipient, the surgical innovations developed to be able to offer them a transplant (reduced size, live donor, split, and auxiliary partial transplantation), the most significant issues in anesthetic, immunosuppressive and postoperative care in children, as well as a global picture of the results. Additionally, the experience of the Hospital Infantil de México Federico Gómez is presented, as the largest and most successful series of pediatric liver transplantation in the country, where the first successful live donor liver transplantation and the first simultaneous liver-kidney transplantation in a child were performed.


REFERENCES

  1. Starzl TE, Marchioro TL, Von Kaulla KN, et al. Homotransplantation of the liver in humans. Surg Gynecol Obstet 1963; 117: 659-76.

  2. Starzl TE, et al. Evolution of liver transplantation. Hepatology 1982; 2: 614.

  3. Starzl TE. The puzzle people: memoirs of a transplant surgeon. Pittsburgh, PA, USA: University of Pittsburgh Press; 1992.

  4. Bucuvalas JC, Ryckman FC. Long-term outcome after liver transplantation in children. Pediatr Transpl 2002; 6: 30-6.

  5. Rand EB, Olthoff KM. Overview of pediatric liver transplantation. Gastroenterol Clin Nort Am 2003; 22: 913-29.

  6. Whitington PF, Balistreri WF. Liver Transplantation in pediatrics: indications, contraindications, and pretransplant management. J Pediatr 1991; 118: 169-77.

  7. Martin SR, Atkison P, Anand R, Lindblad AS, et al. Studies of pediatric liver transplantation 2002: Patient and graft survival and rejection in pediatric recipients of a first liver transplant in the United States and Canada. Pediatr Transpl 2004; 8: 273-83.

  8. Mcdiarmid SV, Anand R, Lindblad AS, et al. Studies of pediatric liver transplantation: 2002 update. An Overview of demographics, indications, timing, and immunosuppressive practices in pediatric liver transplantation in the United States and Canada. Pediatr Transpl 2004; 8: 284-94.

  9. Shneider BL. Pediatric liver transplantation in metabolic disease: Clinical decision making. Pediatr Transpl 2002; 6: 25-9.

  10. Varela-Fascinetto G, Castaldo P, Fox IJ, Sudan D, Heffron TG, Shaw BW, Langnas AN. Biliary atresia-polysplenia syndrome. Surgical and clinical relevance in liver transplantation. Ann Surg 1998; 227: 583-9.

  11. Couinaud C. Les envelopes vasculobiliares de foie ou capsule de Glisson. Leur interet dans la chirugie vesiculaire, les resections hepatiques et lábord du hile du foie. Lyon Chir 1954; 49: 589.

  12. Bismuth H. Surgical anatomy and anatomical surgery of the liver. World J Surg 1982; 6: 3-9.

  13. Bismuth H, Houssin D, Castaing D. Major and minor segmentectomies “Réglées” in liver surgery. World J Surg 1982; 6: 10-24.

  14. Tsakis A, Todo S, Starzl TE. Orthotopic liver transplantation with preservation of the inferior vena cava. Ann Surg 1989; 210: 649.

  15. Broelsch CE, et al. Liver transplantation with reduced size donor organs. Transplantation 1988; 45: 519.

  16. Emond JC, Renz JF. Surgical anatomy of the liver and its application to hepatobiliary surgery and transplantation. Sem Liver Dis 1994; 14: 158-68.

  17. Broelsch CE, Emond JC, Whitington PF, et al. Application of reduced-size liver transplants as split grafts, auxiliary orthotopic grafts, and living related segmental transplants. Ann Surg 1990; 212: 368-77.

  18. Lloyd DM, Pieper F, Gundlach M, et al. Developments in segmental and living related liver transplantation. Transplant Proc 1992; 24: 1287-92.

  19. Broelsch CE, Whitington PF, Emond JC, et al. Liver transplantation in children from living related donors. Surgical techniques and results. Ann Surg 1991; 214: 428-39.

  20. Broelsch CE, Burdelski M, Rogiers X, et al. Living donor for liver transplantation. Hepatology 1994; 20: 49S-55S.

  21. Tanaka K, Uemoto S, Tokinaga Y, et al. Surgical techniques and innovations in living related liver transplantation. Ann Surg 1993; 217: 82-91.

  22. Tanaka K, Uemoto S, Tokinaga Y, et al. Living related liver transplantation in children. Am J Surg 1994; 168: 41-8.

  23. Heffron TG. Living related liver transplantation. Sem Liver Dis 1995; 15: 165-72.

  24. Kawasaki S, Makuuchi M, Matsunami H, et al. Living related liver transplantation in adults. Ann Surg 1998; 227: 269-74.

  25. Emond JC, Whitington PF, Thistlethwaite JR, et al. Transplantation of two patients with one liver. Analysis of a preliminary experience with “split liver” grafting. Ann Surg 1990; 212: 14-22.

  26. Otte JB, De Ville GJ, Reding R, Van OL, et al. Pediatric liver transplantation: from the full-size liver graft to reduced, split, and living related liver transplantation. Pediatr Surg Int 1998; 13: 308-18.

  27. De Ville de Goyet J. Split liver transplantation in Europe-1988 to 1993. Transplantation 1995; 59: 1371-6.

  28. Azoulay D, Astarcioglu I. Bismuth H, et al. Split-liver transplantation. The Paul Brousse policy. Ann Surg 1996; 224: 737-48.

  29. Rogiers X, Malago M, Habib N, et al. In situ splitting of the liver in the heart-beating cadaveric organ donor for transplantation in two recipients. Transplantation 1995; 59: 1081-3.

  30. Rogiers X, Malagó M, Gawad K, et al. In situ splitting of cadaveric livers. The ultimate expansion of a limited donor pool. Ann Surg 1996; 224: 331-41.

  31. Rogiers X, et al. One year of experience with extended application and modified techniques of split liver transplantation. Transplantation 1996; 61: 1059.

  32. Kim JS, Broering DC, Tustas RY, Fischer L, Ganschow R, Burdelsky M, Rogiers X. Split liver transplantation: Past, present and future. Pediatr Transpl 2004; 8: 644-8.

  33. Kaibori M, Egawa H, Inomata Y, Uemoto S, Asonuma K, Kiuchi T, Varela-Fascinetto G, Matsukura T, Kasahara M, Uryuhara K, Inui A, Komatsu H, Fujisawa T, Tanaka K. Selective portal blood flow diversion in auxiliary partial orthotopic liver transplantation to induce regeneration of the graft. Transplantation 1998; 66: 935-7.

  34. Gregory B, Hambre MD, Elliot J, Krane MD. Anaesthesia for liver transplantation in children. Paediatric Anaest 2001; 11: 3-18.

  35. Carmichael FJ, Lindop MB. Anesthesia for hepatic transplantation: cardiovascular and metabolic alterations and their management. Anesth Analg 1985; 64: 108-16.

  36. Carton E, Rettke S, Plerak DJ, Kang YG, Aggarwal. Perioperative care of the liver transplant patient: Part I. Anesth Analg 1994; 78: 120-33.

  37. Aggarwal S, Kang Y, Freeman JA. Is there a post-reperfusion syndrome? Transplant Proc 1989; 21: 3497-9.

  38. Brown A, Williams R. Immediate postoperative care. In: Maddrey WC, Schiff ER, Sorrell MF, eds. Transplantation of the liver. Philadelphia, PA: Lippincott, Williams and Wilkins; 2001, p. 131-62.

  39. Brown A, Williams R. Long-term postoperative care. In: Maddrey WC, Schiff ER, Sorrell MF, eds. Transplantation of the Liver. Philadelphia, PA: Lippincott, Williams and Wilkins; 2001, p. 163-76.

  40. Varela-Fascinetto G, Treacy S, Vacanti JP. Approaching operational tolerance in long-term pediatric liver transplant recipients receiving minimal immunosuppression. Transplant Proc 1997; 29: 449-51.

  41. Calne RY. An opportunity in organ transplantation. Nat Med 1995; 1: 20-2.

  42. Ascher N, Roberts JP. Rejection after transplantation. In: Busuttil RW, Klintmailm GB, eds. Transplantation of the Liver. Philadelphia, PA: W. B. Saunders; 1996, p. 265-73.

  43. Varela-Fascinetto G, Treacy SJ, Lillehei CW, Jonas MM, Lund DP, Kevy SV, Perez-Atayde A, Zurakowski D, Vacanti JP. Long-term results in pediatric ABO-incompatible liver transplantation. Transplant Proc 1999; 31: 467-8.

  44. Balistreri WF. Transplantation for childhood liver disease: An overview. Liver Transpl Surg 1998; 4(5)(Suppl 1): S18-S23.

  45. Humar A, Matas A. Immunosupression: Use in transplantation. In: Encyclopedia of Life Sciences. London, UK: Nature Publishing Group; 2000, Available at http://www.els.net

  46. Margarit C, Asensio M, Dávila R, Ortega J, Iglesias J, Tormo R, Charco R. Analysis of risk factors following pediatric liver transplantation. Transplant Int 2000; 13(Suppl 1): S150-S153.

  47. Varela-Fascinetto G, Dávila-Pérez R, Nieto-Zermeño J, Bracho-Blanchet E, Fuentes-García V, Castañeda-Martínez P, Abarca-García MA, Olivar-López V, Caltenco-Serrano R, Palafox H, Hernández-Plata A, Tovilla-Mercado JM, Lezama-del-Valle P, Valencia-Mayoral P. Experience of a successful pediatric liver transplant program in Mexico. Transplant Proc 2005; 37: 1201-2.




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