medigraphic.com

2015, Number S2

<< Back Next >>

Rev Med Inst Mex Seguro Soc 2015; 53 (S2)

Detection of microRNAs seed sequences within human papillomavirus genomes

Pineda-Gómez D, Garrido E, Chávez P, Salcedo M

Language: Spanish
References: 20
Page: 140-153
PDF size: 505.33 Kb.


ABSTRACT

In this paper we are reporting for the first time the presence of seed sequences of human and viral microRNAs embedded within both high and low risk human papillomavirus (HPV) genomes. These seed sequences have high oncogenic potential. They were found using an in silico analysis based on the microRNA sequences added to Sanger’s database. Among these sequences, it was observed a potential fingerprint harbouring several repeated sequences of microRNA 297 (miR-297) within the LCR region of HPV types 16, 18, 33, 45 and 52. Further analyses were performed for low risk HPV types 6 and 11 and we observed that the probable fingerprint was absent in HPV11, even when we detected other repeated sequences of miR-363. According to these findings, besides the fact that we detected the presence of microRNA sequences within HPV genomes, we suggest a common putative viral mechanism of gene expression regulation shared among human virus.


REFERENCES

  1. Esquela-Kerschner A, Slack FJ. Onomirs – microRNAs with a role in cancer. Nat Rev Cancer. 2006;6:259-69.

  2. Martello G, Zacchigna L, Inui M, Montagner M, Adorno M, et al. MicroRNA control of Nodal signalling. Nature. 2007;449:183-9.

  3. Sarnow P, Jopling CL, Norman KL, Schütz S, Wehner KA. MicroRNAs: expression, avoidance and subversion by vertebrate viruses. Nat Rev Microbiol. 2006;4:651-9.

  4. Griffiths-Jones S. The miRNA Registry. Nucleic Acids Res; 2004;32:D109-D111.

  5. Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A, Enright AJ. miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res. 2006;34:D140-D144.

  6. Griffiths-Jones S, Saini HK, van Dongen S, Enright AJ. Nucleic Acids Res. 2008;36:D154-D158.

  7. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism and function. Cell. 2004;116:281-97.

  8. Vella MC, Slack FJ. C. elegans microRNAs. Wormbook. 2005;21:1-9.

  9. Holland B, Wong J, Li M, Rasheed S. Identification of Human MicroRNA-like sequences embedded within the protein-encoding genes of the human immunodeficiency virus. PLoS ONE. 2013;8:e58586.

  10. Cai X, Schäfer A, Lu S, Bilello JP, Desrosiers R, Edwards R, et al. Epstein-Barr Virus MicroRNAs Are Evolutionarily Conserved and Differentially Expressed. PLoS Pathog. 2006;2(3):e23.

  11. Reshmi G, Pillai MR. Beyond HPV: Oncomirs as new players in cervical cancer. FEBS Lett. 2008;582:4113-6.

  12. Qian K, Pietilä T, Rönty M, Michon F, Frilander MJ, et al. Identification and Validation of Human Papillomavirus Encoded microRNAs. PLoS ONE;2013;8(7): e70202.

  13. Mole S, Milligan SG, Graham SV. Human papillomavirus type 16 E2 protein transcriptionally activates the promotor of a key cellular splicing factor, SF2/ASF. J Virol. 2009;83:357-67.

  14. Chan SY, Ho L, Ong CK, Chow V, Drescher B, et al. Molecular variants of human papillomavirus type 16 from four continents suggest ancient pandemic spread of the virus and its coevolution with humankind. J Virol. 1992;66:2057-66.

  15. Ho L, Chan SY, Burk RD, Das BC, Fujinaga K, et al. The genetic drift of human papillomavirus type 16 is a means of recosntructing prehistoric viral spread and the movement of ancient human populations. J Virol. 1993;67:6413-23.

  16. Ong CK, Chan SY, Campo MS, Fujinaga K, Mavromara-Nazos P, et al. Evolution of human papillomavirus type 18: an ancient phylogenetic root in Africa and intratype diversity reflect coevolution with human ethnic groups. J Virol. 1993;67:6424-31.

  17. Bernard HU, Calleja-Macias IE, Dunn ST. Genome variation of human papillomavirus types: phylogenetic and medical implications. Int J Cancer. 2006;118:1071-6.

  18. Heinzel PA, Chan SY, Ho L, O´Connor M, Balaram P, et al. Variation of human papillomavirus type 6 (HPV-6) and HPV-11 genomes sampled throughout the world. J Clin Microbiol. 1995;33:1746-54.

  19. Bentwich I, Avniel a, Karov Y, Aharonov R, Gilad S, et al. Identification of hundred of conserved and nonconserved human microRNAs. Nat Gen. 2005;37:766-70.

  20. Bernard HU, Chan SY, Manos MM, Ong CK, Villa LL, et al. Assessment of known and novel human papillomaviruses by polymerase chain reaction, restriction digest, nucleotide sequence, and phylogenetic algorithms. J Inf Dis. 1994;170:1077-85.




2020     |     www.medigraphic.com