2015, Number S1
<< Back Next >>
Rev Med Inst Mex Seguro Soc 2015; 53 (S1)
Isotretinoin and depressive symptoms in patiens with severe and recurrent acne
Rubio-García L, Pulido-Díaz N, Jímenez-López JL
Language: Spanish
References: 21
Page: 54-59
PDF size: 73.18 Kb.
ABSTRACT
Background: Since use of isotretinoin for acne management it has been
published controversial results about its association with depression.
The objective of this study was to know if use of isotretinoin in patients
with severe and recurrent acne (SRA) is associated with depression.
Methods: 22 patients with diagnosis of SRA were included from the
National Medical Center La Raza’s Acne Clinic. They completed the
Beck Depression inventory (IDB-II) before, during (2 months) and after
treatment with isotretinoin (4 months), calculated at 0.5 mg/kg.
Results: The patients reported low depressive symptoms before treatment
that reduced at the end (median = 6 and 0, respectively,
p ‹ 0.001).
Conclusions: Treatment with isotretinoin in this sample of patients with
severe and recurrent acne produced no increase in depressive symptoms,
but improvement, due to the best corporal image self-perception.
REFERENCES
Primer Consenso Mexicano para el Manejo del Acné. Dermatol Rev Mex. 2003;47(2):98-100.
Hanna S, Sharma J, Klotz J. Acne vulgaris: More than skin deep. Dermatol Online J 2006;9(3):1-8.
Knutsen-Larson, et al. Acne Vulgaris: Pathogenesis, Treatment and Needs Assessment. Dermatol Clin. 2012;30:99-106
Muizzuddin, N.,Giacomoni, P. and Maes, D. Acne – a multifaceted problem. Drug Discovery Today: Disease Mechanisms. 2008;5(2):e183-188.
Eun Do, J. Psychosocial Aspects of Acne Vulgaris: A Community-based Study with Korean Adolescents. Ann Dermatol. 2009;21(2):125-9.
Fried, R. and Wechsler, A. Psychological problems in the acne patient. Dermatologic Therapy. 2006;19: 237-40.
Keri, J. and Shiman, M. An update on the management of acne vulgaris. Clinical, Cosmetic and Investigational Dermatology. 2009;2:105-10.
Tan, J. Dapsone 5% Gel: A New Option in Topical Therapy for Acne. Skin Therapy Lett 2012; 17(8):1-3.
Simonart, T. Newer Approaches to the Treatment of Acne Vulgaris. Am J Clin Dermatol. 2012;13(6):357-64.
Gómez-Flores M., et al. Uso de isotretinoína en acné común. Rev Med Inst Mex Seg Soc 2011;49 (3):281-8.
Bremner, J and McCaffery, P. The Neurobiology of Retinoic Acid in Affective Disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32(2):315-33.
Douglas, B, Shearer, Kirsty y McCaffery, P. Retinoic Acid and Affective Disorders: The Evidence for an Association. J Clin Psychiatry. 2012;73(1):37-50.
Alcalá, P. Depresión y crisis de pánico en acné tratado con isotretinoína. Semergen. 2012;38(3):188-191.
Halvorsen, J., et al. Suicidal Ideation, Mental Health Problems, and Social Impairment Are Increased in Adolescents with Acne: A Population-Based Study. Journal of Investigative Dermatology. 2011;131:363-370.
Picardi A., et al. Suicide risk in skin disorders. Clinics in Dermatology. 2013;31:47-56.
Féton-Danou, N. Psychological Impact of Acne Vulgaris. Annales of dermatologie. 2010; 137 ( 5): 15-18.
Jacobs, D., Deutsch, N. and Brewer, M. Suicide, depression, and isotretinoin: Is there a causal link?. J Am Acad Dermatol. 2001;45:S168-75.
Cohen, J., Adams, S. and Patten, S. No association found between patients receiving isotretinoin for acne and tha development of depression in a Canadian prospective cohort. Can J Clin Pharmacol. 2007;14(2): e227-33.
Rubinow D. Reduced anxiety and depression in cystic acne patients after successful treatment with oral isotretinoin. J Am Dermatol.1987; 17(1):25-32.
Nevoralová Z, Dvořáková D. Mood changes, depression and suicide risk during isotretinoin treatment: a prospective study. Int J Dermatol. 2013;52 (2):163-8.
Rigopoulos, D., Larios, G. and Katsambas, A. The role of isotretinoin in acne therapy: why not as fi rstline therapy? facts and controversies. Clinics in Dermatology. 2010;28:24-30.