2013, Number 2
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Rev Mex Ing Biomed 2013; 34 (2)
Development of a Software to Determine Disturbances in the Acid-Base Balance in Human Blood
Reyes-Lazalde A, Reyes-Monreal M, Pérez-Bonilla ME, Reyes-Luna R
Language: English
References: 27
Page: 175-191
PDF size: 713.79 Kb.
ABSTRACT
In intensive care units, one of the most frequent emergencies occurring
in patients in critical condition is acid-base imbalance. The ability
to proficiently manage such patients is achieved through many years
of hospital practice. The correct quantification of such imbalances
allows for the detection of complex alterations. Although this area
is fundamental for the clinical management of many patients, nonspecialist
doctors rarely receive the appropriate training. In addition,
the learning required to master this area is difficult for doctors due
to the level of mathematics involved. There are two online support
programs available on the internet for determining blood pH based on
the Stewart Model, along with a spreadsheet for the patient’s collected
data. Generally, the calculation of hydrogen ion concentration [H+]
uses a table of equivalences between pH y [H+] for discontinuous values
of pH, with the Davenport diagram used manually. However, none
of these programs unite the methods of classic calculus, chemistry
and physicochemistry. This study develops software for the teaching
and calculation of acid-base imbalance that combines all the relevant
methods, such as the Henderson-Hasselbalch equation, the Siggard-
Anderson modified excess base equation, the anion gap calculation,
the computational implementation of the Davenport diagram, the
calculus of [H+] for any value of pH, the calculus for the compensatory
process, and the Stewart Model. The combined use of these methods
is complementary, synergic and permits a preliminary diagnosis that
interprets and understands both respiratory alterations and miniscule
metabolic or mixed alterations. With this software, a doctor can
identify acid-base imbalances and the occurrence of compensatory
processes, such as the concentration of acid or base, in order to restore
pH, while many simulations of clinical cases can be carried out in the
classroom for medical training purposes.
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