2013, Number 2
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Rev Mex Ing Biomed 2013; 34 (2)
CAT and MRI Studies of Spinal Cord Injured Rats Implanted with PPy/I
Morales-Guadarrama A, Salgado-Ceballos H, Morales J, Ríos C, Cruz GJ, Diaz-Ruiz A, Olayo MG, Alvarez-Mejia L , Mondragón-Lozano R, Olayo R
Language: English
References: 12
Page: 145-155
PDF size: 849.46 Kb.
ABSTRACT
Polymers synthesized by plasma derived from pyrrole have been recently
implanted in rats with spinal cord injuries (SCI) using a complete
section model; the polymers contribute to the functional recovery
after the injury. In this work, the SCI in rats was studied using
noninvasive techniques such as magnetic resonance imaging (MRI).
Also computerized axial tomography taken chronologically with and
without polymeric implants. 3D reconstructions were used to follow the
structural arrangement, the location of the implant and the formation
of cysts. MRI shows a clear differentiation between white and gray
matter, the implanted material and cysts due to secondary damage
after the injury.
REFERENCES
Bianco J.I., Perry C., Harkin D.G., Mackay-Sim A., Feron. (2004) “Neurotrophin promotes purification and proliferation of olfactory ensheathing cells from human nose.” Glia 45: 111-123.
Lu J., Feron F., Mackay-Sim A., Waite, P.M. (2002) “Olfactory ensheathing cells promote locomotor recovery after delayed transplantation into transected spinal cord.” Brain 125: 14:20.
Thompson F.J., Reier P.J., Uthman B., Mott S., Fessler R.G., Behrman A., Trimble M., Anderson D.K., Wirth III E.D. (2001) “Neurophysiological assessment of the feasibility and safety of neural tissue transplantation in patients with syringomyelia.” J. Neurotrauma 18: 931- 945.
Keirstead H.S., Nistor G., Bernal G., Totoiu M., Cloutier F., Sharp K., Steward O. (2005) “Human embryonic stem cellderived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury.” J. Neurosci. 25: 4694-4705.
Baptiste, D. C., Fehlings, M. G. (2006) “Pharmacological approaches to repair the injured spinal cord.” J. Neurotrauma 23:318-334.
Hall, E. D., Springer, J. E. (2004) “Neuroprotection and acute spinal cord injury: a reappraisal.” NeuroRx 1:80-100.
Kwon B.K., Liu J., Oschipok L., Teh J., Liu Z.W., Tetzlaff W. (2004) “Rubrospinal neurons fail to respond to brain-derived neurotrophic factor applied to the spinal cord injury site 2 months after cervical axotomy.” Exp. Neurol. 189:45-57.
Engesser-Cesar C., Anderson A.J., Basso D.M., Edgerton V.R., Cotman C.W. (2005) “Voluntary wheel running improves recovery from a moderate spinal cord injury.” J. Neurotrauma 22:157-171.
Olayo R., Ríos C., Salgado-Ceballos H., Cruz G., Morales J., Olayo G., Alvarez L., Mondragón R, Morales-Guadarrama A., Guizar-Sahagun G., Diaz-Ruiz A. (2008) “Tissue spinal cord response in rats after implants of polypyrrole and polyethylene glicol obtained by plasma.” Journal of
Cruz G.J., Mondragón-Lozano R., Diaz- Ruiz A., Manjarrez J., Olayo R., Salgado- Ceballos H., Olayo M.G., Morales J., Alvarez-Mejía L., Morales A., Méndez- Armenta M., Plascencia N., Fernandez M., Ríos C. (2012) “Plasma polypyrrole implants recover motor function in rats after spinal cord transection.” J Mater Sci: Mater Med 28:2583-2592.
Bilgen M, Al-Hafez B, Alrefae T, He YY, Smirnova IV, Aldur MM, Festoff BW. (2007) “Longitudinal magnetic resonance imaging of spinal cord injury in mouse: changes in signal patterns associated with the inflammatory response Jun.” Magn Reson Imaging. 25(5):657-64.
Gonzalez-Lara LE, Xu X, Hofstetrova K, Pniak A, Brown A, Foster PJ. (2009) “In vivo magnetic resonance imaging of spinal cord injury in the mouse.” J Neurotrauma. 26(5):753-62.