Vadillo BM, Vela OJ, Galindo RG, Salazar ED

Language: Spanish
References: 18
Page: 99-104
PDF size: 74.11 Kb.

ABSTRACT

Leptin is a protein hormone synthesized and secreted by adipose tissue and also probably in other organs and systems in human body. It has multiple functions such as to regulate feed intake and energy balance, gonadal regulation, action in the hypothalamo-pituitary-gonadal axis, regulates the metabolism of the fetal-placental unit in the pregnancy, fertility and reproductive systems, actions in the endometrium, mammary gland with corresponding influences on important physiologic processes such as menstruation, pregnancy and lactation. In the gynecologic surgery the serum leptin concentration is also modified. The knowledge of serum leptin concentration in the oncological diseases is going-up. Leptin is modified in the choriocarcinoma, Meigs’ syndrome and other tumors. A better understanding of regulatory mechanisms will have direct clinical significance, as leptin has been proposed to impact on those causes of human perinatal morbidity and mortality that are associated with abnormalities of fetal maturity and development, general concept growth, trophoblast endocrinology, and placental sufficiency. Further investigations in this area will be necessary to improve new knowledge and a better understanding of the actions about this hormone.

REFERENCES

1. Christou H, Serdy S, Mantzoros CS. Leptin in relation to growth and developmental processes in the fetus. Semin Reprod Med 2002;20:23-30.

2. Huang KC, Chuang LM, Chen CY, Chow SN, Lin RS. Serum leptin and leptin receptor isoforms in omental adipose tissue of nondiabetic women undergoing gynecologic surgery for benign disease. J Formos Med Assoc 2000;99:839-43.

3. Janeckova R. New findings on the role of leptins in regulation of the reproductive system in humans. Cesk Fysiol 2001;50:25-30.

4. Moschos S, Chan JL, Mantzoros CS. Leptin and reproduction: a review. Fertil Steril 2002;77:433-44.

5. McCann SM, Karanth S, Mastronardi CA, Dees WL, Childs G, Miller B, et al. Control of gonadotropin secretion by follicle-stimulating hormone-releasing factor, luteinizing hormone-releasing hormone, and leptin. Arch Med Res 2001;32:476-85.

6. Ryan NK, Woodhouse CM, van Der Hoek KH, Gilchrist RB, Armstrong DT, Norman RJ. Expression of leptin and its receptor in the murine ovary: possible role in the regulation of oocyte maturation. Biol Reprod 2002;66:1548-54.

7. Gualillo O, Caminos JE, Blanco M, García-Caballero T, Kojima M, Kangawa K, et al. A novel placental-derived hormone. Endocrinology 2001;142:788-94.

8. Gogacz M, Polak G, Jakowicki J, Kotarski J. Peritoneal fluid leptin concentration in infertile patients. J Reprod Inmunol 2001;51:159-65.

9. Hauguelde-Mouzon S, Lepercq J. Placental leptin and pregnancy pathologies. Gynecol Obstet Fertil 2001;29:534-37.

10. Sagawa N, Mori T, Masuzaki H, Ogawa Y, Nakao K. Leptin production by hydatidiform mole. Lancet 1997;350:1518-9.

11. Somasundar P, McFadden DW, Hileman SM, Vona-Davis L. Leptin is a growth factor in cancer. J Surgical Research 2004;116:337-49.

12. Yoshimitsu N, Douchi T, Nagata Y. Perioperative changes in circulating leptin levels in women undergoing total abdominal hysterectomy. Endocr J 2001;48:509-13.

13. Pirwany IR, Fleming R, Sattar N, Greer IA, Wallace AM. Circulating leptin concentrations and ovarian function in polycystic ovary syndrome. Eur J Endocrinol 2001;145:289-94.

14. Kowalska I, Kinalski M, Straczkowski M, Wolczyski S, Kinalska I. Insulin, leptin, IGF-I and insulin-dependent protein concentrations after insulin-sensitizing therapy in obese women with polycystic ovary syndrome. Eur J Endocrinol 2001;144:509-15.

15. Fedorcsak P, Storeng R, Dale PO, et al. Leptin and leptin binding activity in the preovulatory follicle of polycystic ovary syndrome patients. Scand J Clin Lab Invest 2000;60:649-55.

16. Abramov Y, Anteby SO, Fatum M, Fasouliotis SJ, Barak V. The kinetics of leptin in Meigs’ syndrome. Gynecologic Oncology 2001;83:316-8.

17. Odegard RA, Vatten LJ, Nilsen ST, Salvesen KA, Austgulen R. Umbilical cord plasma leptin in increased in preeclampsia. Am J Obstet Gynecol 2002;186:427-32.

18. Anato V, Garmendia JV, Bianco NE, De Sanctis JB. Serum leptin levels in different types of hypertension during pregnancy. Res Commun Mol Pathol Pharmacol 2000;108:147-53.