Manjarrez ME, Rosete DP, Navas A, Santiago J, Calderón I, Chapela R

Language: Spanish
References: 26
Page: 64-68
PDF size: 118.53 Kb.

ABSTRACT

Introduction: Adenoviruses comprise a large family of viruses and some can cause different respiratory diseases of variable severity in children and adults. Objectives: To determine the presence of adenoviruses in patients with acute respiratory diseases. Methods: 145 patients were divided in three groups: 1) from 0 to 18 years (n=22); 2) from 19 to 50 years (n=52); and 3) over 50 years (n=71). Some patients presented at registration clinical histories of respiratory diseases including asthma crisis (n=53) and exacerbation of chronic bronchitis (n=54); and some with no previous history presented inflammation of upper airways (n=38). The presence of viruses was detected by isolation in cell cultures, viral antigen identity was confirmed by indirect immunofluorescence and antibodies were evaluated by complement fixation assay. Results: In the first group (n=22), adenoviruses were isolated and identified in 13.63%; 13.46% in the second group (n=52); and 9.4% in the third group (n=71). In the case of antibodies, 47.6% of the serum samples presented specific antibodies. Conclusions: This study suggests that adenoviruses are present in various respiratory diseases, and that they can play an important role in respiratory inflammatory diseases.

REFERENCES

1. Holladay RC, Cambell GD. Nosocomial viral pneumonia in the intensive care unit. Clin Chest Med 1995;16:121-133.

2. Murtagh P, Cerqueiro C, Halac A, Avila M, Cajón A. Adenovirus type 7h respiratory infections: a report of 29 cases of acute lower respiratory disease. Acta Ped 1993;82:557-561.

3. Edwards KM, Thompson J, Paolini J, Wright PF. Adenovirus infections in young children. Pediatrics 1985;76:420-424.

4. Quiambao BP, Gatchalian SR, Halonen P, Lucero M, Sombrero L, Paladin FJ, et al. Coinfection is common in measles-associated pneumonia. Pediatr Infect Dis J 1998;17:89-93.

5. Penn CC, Liu C. Bronchiolitis following infection in adults and children. Clin Chest Med 1993;14:645-654.

6. Abbondanzo SL, English CK, Kagan E, McPerson RA. Fatal adenovirus pneumonia in newborn identified by electron microscopy and in situ hybridization. Arch Pathol Lab Med 1989;113:1349-1353.

7. Sonoda S, Gotoh Y, Bann F, Nakayama T. Acute lower respiratory infections in hospitalized children over a 6 years period in Tokio. Pediatric Int 1999; 41:519-524.

8. Parrott RH, Vargosko AJ, Kim HW, Chanock RM. Clinical syndromes among children. Am Rev Respir Dis 1963;88:73-88.

9. Harsten G, Prellner K, Löfgren B, Kalm O. Serum antibodies against respiratory tract viruses in episodes of acute otitis media. J Laryngol Otology 1991;105:337-340.

10. Blanding JG, Hoshiko MG, Stutman HR. Routine viral culture for pediatric respiratory specimens submitted for direct immunofluorescence testing. J Clin Microbiol 1989;27:1438-1440.

11. Videla C, Carballal G, Misirlian A, Aguilar M. Acute lower respiratory infections due to respiratory syncitial virus and adenovirus among hospitalized children from Argentina. Clin Diagn Virol 1998;10:17-23.

12. Nicholson KG, Kent J, Ireland DC. Respiratory viruses and exacerbations of asthma in adults. Br Med J 1993; 307: 982-986.

13. Crawfford-Miksza LK, Nang RN, Schnurr DP. Strain variation in adenovirus serotypes 4 an 7 a causing acute respiratory disease. J Clin Microbiol 1999; 37:1107-1112.

14. Shult PA, Polyak F, Dick EC, Warshauer DM, King LA, Mandel AD. Adenovirus 21 infection in an isolated antartic station: transmission of the virus and susceptibility of the population. Am J Epidemiol 1991;133:599-607.

15. Flomenberg P, Piaskowski V, Truitt RL, Casper JT. Characterization of human proliferative T cell responses to adenovirus. J Infect Dis 1995; 171:1090-1096.

16. Matsuse T, Hayashi S, Kuwano K, Keunecke H, Jefferies WA, Hogg JC. Latent adenoviral infection in the pathogenesis of chronic airways obstruction. Am Rev Respir Dis 1992;146:177-188.

17. Beasley R, Coleman DE, Hermon Y, Holst PE, O´donnell TV, Tobias M. Viral respiratory tract infection exacerbations of asthma in adult patients. Thorax 1988; 43:679-683.

18. Pizarro E, Reséndiz LJ, Quintero ME, Arreguín ML. Investigación de anticuerpos hacia los adenovirus: III Estudio en dos comunidades cerradas. Rev Lat-Amer Microbiol Parasitol 1966; 8:9-12.

19. Willing FM, Lewis AL. Complement fixation test. In: Specter S, Lancz GJ, editors. Clinical virology manual. New York: Elsever, 1986:159-185.

20. Nohynek H, Eskola J, Laine E, Halonen P, Ruutu P, Saikku P, et al. The causes of hospital-treated acute lower respiratory tract infection in children. Am J Dis Child 1991; 145:618-622.

21. Chan PW, Goh AY, Chua KB, Kharullah NS, Hooi PS. Viral aetiology of lower respiratory tract infection in young malay sian children. J Pediatric Child Health1999;35:287-290.

22. Nicholson KG, Kent J, Ireland DC. Respiratory viruses and exacerbation of asthma in adults. B Med J 1993;307:982-983.

23. Videla C, Carballal G, Kajon A. Genomic analysis of adenovirus isolated from Argentinian children with acute lower respiratory infections. J Clin Virol 1999; 14:67-71.

24. Nelson JK, Shieds MD, Stewart MC, Coyle PV. Investigation of seroprevalence of respiratory virus infections in an infant population with a multiantigen fluorescence immunoassay using heel-prick blood samples collected on filter paper. Pediatr Res 1999; 45:799-802.

25. Huang JJ, Huang TY, Huang MY, Chen BH, Lin KH, Jeng JE, et al. Simultaneos multiple viral infections in childhood acute lower respiratory trac infections in Southern Taiwan. J Trop Pediatric 1998; 44:308-311.

26. Gatchalian SR, Quiambao BP, Morelos AM, Abraham L, Gepanayao CP, Sombrero LT, et al. Bacterial and viral etiology of serious infections in very young Filipino infants. Pediatric Infect Dis 1999; 18:50S-55S.