2014, Number 2
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Rev Mex Ing Biomed 2014; 35 (2)
Effects of Impaired ATP Production and Glucose Sensitivity on Human β -Cell Function: A Simulation Study
Félix-Martínez GJ, Azpiroz-Leehan J, Ávila-Pozos R, Godínez Fernández JR
Language: English
References: 41
Page: 157-170
PDF size: 664.06 Kb.
ABSTRACT
In this paper we used a mathematical model to explore the effects
of impaired ATP production and glucose sensitivity on the electrical
response and insulin secretion of human β-cells. The model was
extended by the addition of explicit empirical equations that describe
recent experimental observations, namely, the increase of ATP as
a function of glucose concentration and the oscillations in ATP at
high glucose levels. Simulations were performed at selected glucose
concentrations from an oral glucose tolerance test in normal subjects to
evaluate the response of the human β-cell in normal and pathological
scenarios. Our simulations reproduced experimental observations, such
as the impaired insulin secretion as a consequence of β-cell dysfunction
and restoration of electrical activity by the use of a sulfonylurea. Our
results suggest that both reduced glucose sensitivity and impaired ATP
production could be related to the pathogenesis of type 2 diabetes.
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