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2015, Number 3

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Rev Cuba Endoc 2015; 26 (3)

Adiposity, insulin resistance, blood pressure and ventricular geometry of children and adolescents

Marín JSM, Argoti NJS, Cabrera RJO

Language: Spanish
References: 54
Page: 222-237
PDF size: 304.31 Kb.


ABSTRACT

Introduction: high prevalence of obesity in childhood is associated to premature development of cardiovascular risk factors such as dyslipidemia, blood hypertension and insulin resistance.
Objective: to identify whether there is association between anthropometric variables of adiposity and biochemical variables with the blood pressure and the left ventricle mass values in children and adolescents.
Methods: a cross-sectional observational study conducted in 96 patients who were 9 to 16 years of age and had been seen at pediatric endocrinology service of the National Institute of Endocrinology from November 2012 to April 2013; a nonprobabilistic method at convenience was used. Demographic, clinical, anthropometric, biochemical and echocardiographic variables were included.
Results: systolic blood pressure values were significantly higher in those with total body obesity (110 ± 11 vs. 105 ± 11 mmHg, p = 0.026) and those with abdominal obesity (111 ± 11 vs. 105 ± 12 mmHg, p = 0.013) than in those who had body mass index under 97 percentile. Total body obesity was related to high triglyceride and uric acid values, the abdominal obesity to family history of blood hypertension, and both types of obesity were significantly associated with the family history of diabetes and the Mathews homeostatic model- insulin resistance values. The left ventricle mass was remarkably greater in those with total body obesity (118 ± 39 vs. 96 ± 35 g/m2, p = 0.008) and with abdominal obesity (123 ± 39 vs. 97 ± 34 g/m2, p = 0.001). Mathews homeostatic model-insulin resistance showed significant positive correlation with the left ventricle mass (r = 0.496; p ‹ 0.001).
Conclusions: active search through an echocardiographic test allows identifying structural changes in the heart and in the vascular floor of children and adolescents with obesity and insulin resistance.


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