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2002, Number 1

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Rev Inst Nal Enf Resp Mex 2002; 15 (1)

Tumor necrosis factor: biological activity in interstitial pneumopathies.

Falfán VR

Language: Spanish
References: 22
Page: 48-53
PDF size: 192.68 Kb.


ABSTRACT

The TNF was found initially in mouse serum, which had previously been treated with lipopolysaccharide (LPS). Currently, TNF is known to be involved in the response to several stimulants, causing an inflammatory and immune event. Although a variety of cell types can induce this cytokine, macrophages represent the main cellular source for the soluble form. TNF elicits a wide spectrum of organism and cellular responses, ranging from fever and tissue injury to induction of other cytokines and immunoregulatory molecules. Localization and description of polymorphisms at the upstream promoter region of the human TNF gene has revealed some associations between these polymorphisms and inflammatory diseases. This review focuses on the information available on TNF gene polymorphisms and their associations currently described in interstitial lung disease.


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