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ISSN 1527-3172 (Electronic)

2007, Number 1

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MEDICC Review 2007; 9 (1)

Design & methodology of the isle of youth community-based epidemiological study of CKD, cardio-cerebral vascular disease, hypertension, and diabetes mellitus (ISYS)

Almaguer LM, Herrera VR, Chipi CJ, Toirac CX, Castellanos RO, Bacallao GJ

Language: English
References: 27
Page: 23-30
PDF size: 1083.61 Kb.


ABSTRACT

The methodology is described in detail for the population-based Isle of Youth Study (ISYS) for epidemiological evaluation of CKD associated with cardio-cerebral vascular disease, arterial hypertension, diabetes mellitus, and other risk factors.
Background Chronic kidney disease emerges as an important and growing global health problem associated with an increase in the incidence and prevalence of the above mentioned diseases.
ISYS Objectives Ascertain CKD morbidity and its relation to chronic vascular diseases and other risk factors in whole population of Cuba’s Isle of Youth special municipality.
Method 96.6% of the Isle of Youth’s total population (80,117 inhabitants) was studied, all ages and both sexes, November 15, 2004-April 30, 2006. The public was offered general information on the objectives and benefits of the study, and participants provided informed consent. Active screening was performed via personal interview questionnaire and urine sample to determine markers of kidney damage: proteinuria and hematuria (Combur-10-Test) and microalbuminuria (Micral-Test), according to a diagnostic algorithm. For those testing positive for any marker, serum creatinine was studied and glomerular filtration rate (GFR) calculated – in adults by Cockcroft-Gault and Modification of Diet in Renal Disease (MDRD) formulas and in children aged ‹15 years, by Schwartz – to stratify CKD by stages. Blood pressure, height, weight, and body mass index (BMI) were determined.
Expected Results Prevalence of kidney damage markers in general population and risk groups; relationship in population between CKD and cardio-cerebral vascular disease, diabetes mellitus, hypertension, and other risk factors; comparison of Cockcroft-Gault and Modification of Diet in Renal Disease (MDRD) formulas for measuring the GFR and their application to studies involving mass population screenings; and stratification of CKD in population.
Conclusions ISYS Phase I, active screening of markers for renal damage was concluded using the methodology described above; results are pending publication.


REFERENCES

  1. Dirks JH, Dezeeuw D et al. Prevention of chronic kidney and vascular disease: toward global health. The Bellagio 2004 Declaration. Kidney Int 2005;68:S1-S6.

  2. Dirks JH, Robinson SW, Alderman M, Couser WG, Grundy SM, Smith SC, et al. Meeting Report on the Bellagio Conference. “Prevention of vascular diseases in the emerging world: an approach to global health equity.” Kidney Int 2006;70:1397-402.

  3. Almaguer M, Herrera R, Pérez-Oliva J. Epidemia global de enfermedades vasculares crónicas. Un nuevo paradigma y desafío. Rev Hab de Ciencias Médicas. Forthcoming 2007.

  4. Yusuf S. Global burden of cardiovascular diseases. Part I. General considerations, the epidemiologic transition, risk factors and impact of urbanization. Circulation. 2001;104:2746-53.

  5. International Diabetes Federation. Diabetes Atlas. 2nd ed. 2004. Brussels (Belgium); 2004.

  6. King H, Aubert RE, Hermann WH. Global burden of diabetes. 1995- 2025, prevalence, universal estimates and projections. Diabetes Care.1998;21: 1414-31.

  7. Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet 2005;365:217- 223.

  8. Lysaght M. Maintenance dialysis population, dynamics, current trends and long term implications J Am Soc Nephrol 2002;13:S37-S40.

  9. World Kidney Day. An idea whose time has come. Kidney Int 2006;69:781-2.

  10. Dirks J. A world perspective on renal care. The challenges of prevention and treatment. EDTNA/ERCA J 2005;31:72- 4.

  11. Anuario Estadístico de Salud. Cuba. 2004. Dirección Nacional de Estadísticas. Ministerio de Salud Pública. Cuba. 2004.

  12. Coresh J, Astor B, Greene T et al. Prevalence of CKD and decreased kidney function in the adult US population. Third National Health and Nutrition Examination Survey. Am J Kidney Dis 2003;1(19):1-12.

  13. Saydah S et al. Prevalence of CKD and associated risk factors. United States 1999-2004. MMWR Weekly 2007;56 (08):161-5.

  14. Chadban S, Briganti E, Keer P et al. Prevalence of kidney damage in Australian adults. The Austr Kidney Study. J Am S Nephrol 2003;14 (Suppl 2):S131- S138.

  15. Hillege HL, Janssen WMT, Bak AAA, Diercks GFH, Grobee DE, Crijins HJGM et al. Microalbuminuria is common also in a nondiabetic, nonhypertensive population and an independent indicator of cardiovascular risk factors and cardiovascular morbidity. J Int Med 2001;249 (6):519-526.

  16. Censo de población y viviendas 2002. Cuba. http://www.cubagov.cu/otras_info/ censo/población.htm (accessed 5 July 2007).

  17. Departamento de Estadísticas. Dirección Municipal de Salud. Isla de la Juventud. Población dispensarizada por los médicos de la familia. Departamento de Estadísticas. Dirección Municipal de Salud. Isla de la Juventud. Cuba. 2004.

  18. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976;16:31-41.

  19. DuBois D, Dubois EF. A formula to estimate the approximate surface area if height and weight be known. Arch Intern Med 1916;17:863-71.

  20. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine. A new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 1999;130:461-70.

  21. Levey AS, Greene T, Kusek JW, Beck GJ, and MDRD Study Group. A simplified equation to predict glomerular filtration rate from serum creatinine. J Am Soc Nephrol 2000;11:155A (abstr A0828).

  22. Schwartz GI, Brion LP, Spitzer A. The use of plasma creatinine concentration for estimating glomerular filtration rate in infants, children and adolescents. Pediatr Clin N Amer 1987;34:540-71.

  23. Hogg RJ, Furth S, Lemley KV et al. National Kidney Foundation. Kidney Disease Outcomes Quality Initiative Clinical Practice Guidelines for Chronic Kidney Disease in Children and Adolescents: Evaluation, Classification and Stratification. Ped 2003;111 (6):1416-21.

  24. National Kidney Foundation: K/DOQI. Clinical Practice Guidelines for Chronic Kidney Disease: Evaluation, Classification and Stratification. Am J Kidney Dis 2002;39:S1-S266.

  25. Levey AS, Eckardt KU, Tsukamoto Y, Levin A et al. Definición y clasificación de la enfermedad renal crónica: Propuesta de KDIGO (Kidney Disease: improving global outcomes). Kidney Int (edición español) 2005;1:135-46.

  26. Chobaniam AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, Jones DW, Materson BJ, Wright JT, Roccella EJ and the National High Blood Pressure Education Program Coordinating Committee. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure. JAMA:289:2560- 72.

  27. Task Force on High Blood Pressure in Children and Adolescentds. Ped 1996;98:649-58.




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