Charas SIF, Nhambirre A, Bata BO, Mota CJM, Celeita RN, López CBS

Language: Spanish
References: 24
Page: 348-357
PDF size: 256.56 Kb.

ABSTRACT

Introduction: Cissus quadrangularis (Linn) has healing, analgesia and antiinflammatory effects. Phyllanthus reticulatus Poir (Linn) is used for treating skin wounds, burns and ulcers.
Objectives: to compare the effectiveness of C. quandrangularis and P. reticulatus in wounds healing surgically induced in skin of guinea pigs, evaluating the healing time, microscopic and macroscopic healing variations and contamination degree.
Methods: Was used in study 30 health guinea pigs, males, six months old, with mean weight of 650 grams. Three wounds were promoted in each animal in the dorsal region and the wound was treated, daily, with C. quandrangularis, saline solution 0.9% and with P. reticulatus. The biopsies were performed in Group I on the seventh day after the surgery, Group II on the fourteenth day and the Group III on the twenty-first day after the surgery and sent to histopathologycal evaluation.
Results: on the seventh day of treatment the wounds which treated with C. quadrangularis were observed granulation tissue, while wounds treated with P. reticulatus were observed on the ninth day after. No healing significant difference occurred between the treatments. During the study was observed predominance of neutrophils in all wounds of all groups, more evident in those treated with C. quandrangularis.
Conclusion: The wounds which treated with C. quandrangularis healed faster and showed less contamination degree than treated with P. reticulatus.

REFERENCES

1. Murthy EN, Sudhakar C, Reddy KN, Raju VS. Ethnomedicinal observations from the Maha-Mutharam and Yanampally Tribal Villages of Karimnagar, East Forest Division of Andhra Pradesh, India. Ethnobot Leaflets. 2008;12(3):513-19.

2. McGaw LJ, Eloff JN. Ethnoveterinary use of Southern African Plants and scientific evaluation of their medicinal properties. J Ethnopharm. 2008;119(1):560.

3. Sharma A, Patel VK, Chaturvedi AN. Vibriocidal activity of certain medicinal plants used in Indian Folklore Vegetable Tribals of Mahakoshal Region of Central India. J Pharm. 2009;41(4):129-33.

4. Branco Neto C, Lages M, Marcondes J, Malafaia O, Oliveira Filho MA, Czeczko GN, et al. Avaliação do extrato hidroalcoólico de aroeira (Schinus terebinthifolius Raddi) no processo de cicatrização de feridas em pele de ratos. Acta Cir Bras. 2006;21(2):17-22.

5. Manganelli RU, Camangi F, Tomei PE. Curing animals with plants: traditional usage in Tuscany (Italy). J Ethnopharm. 2001;78(5):171-91.

6. Adewunmi CO, Agbedahunsi JM, Adebajo AC, Aladesanmi AJ, Murphy N, Wando J. Ethno-veterinary medicine: screening of Nigerian medicinal plants for trypanocidal properties. J Ethnophar. 2001;77(6):19-24.

7. Rahal SC, Rocha NS, Blessa EP, Iwabe S, Crocci AJ. Pomada orgânica natural ou solução salina isotônica no tratamento de feridas limpas induzidas em ratos. Ciênc rural. 2001;31(3):1007–11.

8. Resende MA, Pereira LS, Castro MA. Proposta de um modelo teórico de intervenção fisioterapêutica no controle da dor e inflamação. Fisiot Bras. 2005;6(11):368-70.

9. Lucena PH, Ribas Filho JM, Mazza M. Avaliação da Aroeira (Schinus terebinthifolius Raddi) na cicatrização de feridas cirúrgicas em bexiga de ratos. Acta Cir Bras. 2006;21(6):46–51.

10. Toyang NJ, Wanyama J, Nuwanyakpa M. Medicina Etnoveterinária – Uma Abordagem Prática do Tratamento de Doenças de Gado na África Sub-Sahariana. 1ª ed. São Paulo: Wageningen; 2007. p. 51-5.

11. Schimidt E, Lotter M, McCleland W. Trees and Shrubs of Mpumalanga and Kruger national Park. 1ª ed. South Africa Press: Cape Town; 2002. p. 28-32.

12. Shirwaikar A, Khan S, Malini S. Antiosteoporotic effect of ethanol extract of Cissus quadrangularis (Linn) on ovariectomized rat. Ethnopharm. 2003;89(2):129-33.

13. Panthong A, Supraditaporn W, Kanjanapothi D. Analgesic, anti-inflammatory and venotonic effects of Cissus quadrangularis (Linn). J Ethnopharm. 2007;(5):10.

14. Oben JE, Enyegue DM, Fomekong GL. The Effect of Cissus quadrangularis (CQR-300) and Cissus formulation (CORE) on Obesity and Obesity-induced oxidative Stress. Lipids in Health and Disease. 2007;6(2):4-6.

15. Muthulakshmi S, Jayanthi JP. Pharmacognostical and preliminary phytochemical studies on two medicinal plants. Phyllanthus emblica and Phyllanthus reticulatus. Ethnobot Leaflets. 2001;3(3):69-70.

16. Oliveira DF. Antibacterial activity of plant extracts from Brazilian southeast region. Fitoterapia. 2007;2(4):142-3.

17. Santos IFC, Grosso SRS, Bambo OB, Nhambirre AP, Cardoso JMM, Schmidt EMS, et al. Mel e açúcar mascavo na cicatrização de feridas . Ciênc rural. 2012;42(3):2219-24.

18. Kushner I, Rzewnicki D. The acute phase response: general aspects. In: Husby B. (ed.). Reactive Amyloidosis and the Acute Phase Response. Bailliere Tindall: London. 1994:513–30.

19. Gabay C, Smith JR, Eidlen MF, Arend WP. Interleukin-1 receptor antagonist is an acute-phase protein. J Clin Invest. 1997;99(1):2930–40.

20. Paschoalini MA. Regulação do peso corporal. In: Seminário de interação sobre os aspectos morfofuncionais orais de clínica médica e de saúde pública. Universidade Federal de Santa Catarina, Brasil. 2005. p. 76.

21. Balbino CA, Pereira LM, Curi R. Mecanismos envolvidos na cicatrização. Bra J Pharm Sci. 2005;41(6):24-6.

22. Mogicato G, Layssol-Lamour C, Conchou F, Diquelou A, Raharison F, Sautet J, et al. Evaluation of repeatability, reproducibility, observer-dependent variability, and the effect of bodyweight, age and sex. Vet Rec. 2011;168(2):130.

23. Singer AJ, Clark RA. Cutaneous wound healing. J Med. 1999;341(5):738-46.

24. Deodhar AK, Rana RE. Surgical physiology of wound healing: a review. J Post Grad Med. 1997;43(1):52-6.