González-Ponce F, Flores-Chávez A, Ramírez-Villafańa M, Pérez-Guerrero E, Romero-Moreno JR, Saucedo-Ulloa M, Aguirre-Romo A, Huerta-Viera M, Trujillo-Trujillo X, González-López LC

Language: Spanish
References: 28
Page: 125-131
PDF size: 258.87 Kb.

ABSTRACT

The chemerin is a recently described adipokine whose role is to regulate lipid and carbohydrate metabolism through systemic actions. The precise mechanism by which the chemerin may be associated with the metabolic syndrome is not yet fully understood. The binding of the chemerin with its respective receptor subsequently cause inhibition of phosphorylation of insulin enhancer and activation of 5-AMP-activated protein kinase (AMPc), inducing insulin resistance in skeletal muscle, considered one of the main factors for MS development. Alterations in lipid profile within the MS related to chemerin level in serum appear to result from insulin resistance, in which the transport of glucose to skeletal muscle decreases, inducing hepatic gluconeogenesis. Recently it has been suggested that chemerin plays a key role in metabolism and may be involved in the development of MS, because it is elevated in adipose tissue and high circulating levels of this adipokine are seen in patients with a higher degree of adiposity compared with those of healthy weight.

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