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ISSN 1684-1824 (Electronic)

2015, Number 6

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Rev Méd Electrón 2015; 37 (6)

Melanosis coli: endoscopic diagnosis. Case report

Morales DM, Corrales AS, Haza MT, Laúd MPM, Manuel PF

Language: Spanish
References: 17
Page: 641-647
PDF size: 265.87 Kb.


ABSTRACT

The Melanosis coli consist in a blackish pigmentation of the large intestine mucosa, produced for the absorption of aromatic products due to the excessive usage of anthracene-derived laxatives. We present the first case of Melanosis coli diagnosed in the Gastroenterology Department of the Hospital “Faustino Perez”, of Matanzas in the last 30 years. It is the case of a patient with antecedents of chronic constipation, to whom the disease is diagnosed as a result of a colon videoendoscopic study, corroborated by histological study, concluding that this disease is an innocuous condition without clinical manifestations. It almost always appears in an accidental way, in patients to whom endoscopic studies of the low digestive tract are carried out, and having a history of laxatives abuse. To avoid it, an adequate hygiene-epidemiologic regime, rich-in-fibers food consumption, systemic physical training and the proscription of anthraquinone-derived laxatives are need. It is very importance for the gastroenterologists to be conscious of the existence of this entity, although its clinical importance is not elucidated yet.


REFERENCES

  1. 1- Wexner SD, Bartolo DCC, editores. Estreñimiento. Etiología, diagnóstico y tratamiento. Barcelona: EdikaMed; 1996.

  2. 2- Müller Lissner SA. Adverse effects or laxatives: fact and fiction. Pharmacology [Internet]. 1993 [citado 23 Ene 2015];47:138-45.Disponible en: http://www.karger.com/Article/Abstract/139853

  3. 3- Freeman HJ. Melanosis in the small and large intestine. World J Gastroenterol 2008;14(27): 4296-99. Citado en PubMed; PMCID: PMC2731179.

  4. 4- Chuaqui B, González JS. Alteraciones de los pigmentos: Manual de patología general. Chile: Universidad católica de Chile; 2006.

  5. 5- Coyne JD. Melanosis coli in hyperplastic polyps and adenomas. International J Surgical Pathology [Internet]. 2013 [citado 23 Ene 2015];21(3):261-3. Disponible en: http://ijs.sagepub.com/content/early/2012/11/30/106689691246821

  6. 6- Wang T, Chen ZW, Streutker CJ. Melanosis coli sparing adenomatous polyps: novel findings using cleaved caspase-3 immunohistochemistry. Histopathology [Internet]. 2013 [citado 23 Ene 2015]; 62(5):819-21. Disponible en: http://onlinelibrary.wiley.com/doi/10.1111/his.12072/full

  7. 7- Chen JY, Pan F, Zhang T, Xia J, Li Yan J. Experimental study on the molecular mechanism of anthraquinone cathartics in inducing melanosis coli. Chinese J Integrative Medicine [Internet]. 2011 [citado 23 Ene 2015];17(7):525-30. Disponible en: http://link.springer.com/article/10.1007/s11655-011-0786-z#page-1

  8. 8- Mellouki I, Meyiz H. Melanosis coli: a rarity in digestive endoscopy. Pan Afr Med J [Internet]. 2013 [citado 23 Ene 2015];16:86. Disponible en: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976655/pdf/PAMJ-16-86.pdf

  9. 9- Chaudhary BN, Sharma H, Nadeem M, Niayesh MH. Ischemic colitis or melanosis coli: a case report. World J Emerg Surg. 2007;2:25. Citado en PubMed: PMCID: PMC2077330.

  10. 10- Serra J, Pino CM. Melanosis Coli secundaria al abuso de laxantes del antraceno. Presentación de un caso clínico-endoscopico [Internet]; 2011 [citado 23 Ene 2015]. Disponible en: http://medicaldiagnstic.blogspot.com/2011/05/melanosis-coli-secundaria- al-abuso-de.html

  11. 11- Kew ST, Chakravarthi S. Melanosis coli. N Engl J Med [Internet]. 2013 [citado 23 Ene 2015];368(24): 2303. Disponible en: http://www.nejm.org/doi/full/10.1056/NEJMicm1204882

  12. 12- Chuan Wang Z, Gao J, Ming Zi S, Yang M, Du P, Cui L. Aberrant expression of sonic hedgehog pathway in colon cancer and melanosis coli. Journal Of Digestive Diseases [Internet]. 2013 [citado 23 Ene 2015];14(8):417-24. Disponible en: http://onlinelibrary.wiley.com/doi/10.1111/1751-2980.12060/full

  13. 13- Loveday RL, Hughes MA, Lovel JA, Duthie GS. Melanosis coli in the absence of anthranoid laxative use harbouring adenoma. Colorectal Disease [Internet]. 2013 [citado 23 Ene 2015];15(8):1044-5. Disponible en: http://onlinelibrary.wiley.com/doi/10.1111/codi.12254/abstract

  14. 14- Kunkel J, Schmidt S, Loddenkemper C, Zeitz M, Schulzke JD. Chronic diarrhea and melanosis coli caused by wellness drink. International Journal Of Colorectal Disease [Internet]. 2009 [citado 23 Ene 2015];24(5):595-6. Disponible en: http://link.springer.com/article/10.1007/s00384-008-0625-7

  15. 15- Kew ST, Chakravarthi S. Images in clinical medicine: Melanosis coli. N Engl J Med [Internet]. 2013 [citado 23 Ene 2015];368(24):2303. Disponible en: http://www.nejm.org/doi/pdf/10.1056/NEJMicm1204882

  16. 16- Coyne JD. Melanosis coli can involve adenomatous polyps. Histopathology [Internet]. 2014 [citado 23 Ene 2015];64(2):311-2. Disponible en: http://onlinelibrary.wiley.com/doi/10.1111/his.12245/abstract

  17. 17- Martín Lagos Maldonado A, del Moral Martínez M, Berenguer Guirado R, Casado Caballero FJ. Enfermedad celiaca y melanosis coli: una asociación inusual. Revista andaluza de patología digestiva [Internet]. 2013 [citado 23 Ene 2015];36(6):446-7. Disponible en: http://www.sapd.es/revista/rapd.php?capitulo=502




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