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ISSN 1405-1710 (Print)

2015, Number 2

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Rev Cent Dermatol Pascua 2015; 24 (2)

Cancer stem cells: current concepts

Alcalá PD, Barrera PM, Castañeda YR, Cabrera PAL

Language: Spanish
References: 31
Page: 47-51
PDF size: 232.28 Kb.


ABSTRACT

All body tissues are derived from stem cells. These cells are defined by their ability to undergo self-renewal, as well as to differentiate in a controlled way. Cancer stem cells are neoplastic cells with an indefinite potential for self-renewal, and therefore, oncogenic capacity. Recent investigations report that a fraction of these neoplastic cells are considered cancer stem cells, which explains the continuous resistant to the treatment and tumoral recurrence. The cancer stem cell hypothesis has fundamental implications for understanding the biology of cutaneous carcinogenesis as well as for developing new strategies for cancer prevention and therapies for advanced disease. In this article, we provide a brief overview of stem cells, cancer stem cell theories, and their role in dermato-oncology.


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