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2015, Number 3

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Rev Cub de Reu 2015; 17 (3)

Epigenetics and autoimmune systemic diseases

Torres LAM, Rodríguez TAY

Language: Spanish
References: 74
Page: 216-221
PDF size: 115.03 Kb.


ABSTRACT

Epigenetics as the science about inheritables modifications of genetic information without DNA sequence changes, is atracting an increasing focus among scientific community, for his contribution in pathogenesis, therapeutic approaches and even in prevention of many diseases. Systemic autoimmune diseases have a multifactorial complex pathogenesis and in the last few years there are numerous clinical and experimental evidences, about the influence of epigenoma changes in these diseases, so we pretend to review them in this Article series.


REFERENCES

  1. Absher DM, Li X, Waite LL, Gibson A, Roberts K, Edberg J et al. Genome-wide DNA methylation analysis of systemic lupus erythematosus reveals persistent hypomethylation of interferon genes and compositional changes to CD4+ T-cell populations. PLoS Genet 2013; 9: e1003678

  2. Aguilar-Arnal L, Sassone-Corsi P. The circadian epigenome: how metabolism talks to chromatin re-modeling. Curr Opin Cell Biol. 2013;25:170-6.

  3. Allan RS, Zueva E, Cammas F, Schreiber HA, Masson V, Belz GT et al. An epigenetic silencing pathway controlling T helper 2 cell lineage commitment. Nature. 2012;487:249-253.

  4. Ameres SL, Zamore PD. Diversifying microRNA sequence and function. Nat Rev Mol Cell Biol. 2013;14:475-88.

  5. Arpaia N, Campbell C, Fan X, Dikiy S, van der Veeken J, deRoos P. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature. 2013;504:451-5.

  6. Azzi, A. et al. Circadian behavior is light-reprogrammed by plastic DNA methylation. Nat. Neurosci. 2014;17:377-382.

  7. Ballestar E. Epigenetic alterations in autoimmune rheumatic diseases. Nat Rev Rheumatol. 2011;7:263-271. doi:10.1038/nrrheum. 2011.16.

  8. Baranzini, S. E. et al. Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis. Nature. 2010;464: 135-6.

  9. Baylin SB, Jones PA. A decade of exploring the cancer epigenome — biological and translational implications. Nat Rev Cancer. 2011;11: 26-34. doi:10.1038/nrc3130

  10. Bell C.G, Beck S. The epigenomic interface between genome and environment in common complex diseases. Brief. Funct. Genomics. 2010;9:477-85.

  11. Bell S.P et all. Epigenetic Gene regulation. En The molecular biology of gene. Watson JD, Gann A, Baker TA, Levine M, Michael TA, Bell S.P, Losick R, Harrison SC. S e v e n t h e d i t i o n. California: Ed. Berkeley. 2014;694-99.

  12. Berger, S. L., Kouzarides, T., Shiekhattar, R., and Shilatifard, A. An operational definition of epigenetics. Genes Dev. 2009;23,781-3. doi: 10.1101/gad.1

  13. Blank M, Shoenfeld Y, Perl A. Cross-talk of the environment with the host genome and the immune system through endogenous retroviruses in systemic lupus erythematosus. Lupus. 2009 Nov;18(13):1136-43.

  14. Brooks, W. H., Le Dantec, C., Pers, J. O., Youinou, P., and Renaudineau, Y. Epigenetics and autoimmunity. J. Autoimmun. 2010;(34):J207-J219. doi: 10.1016/j.jaut.2009.12.006

  15. Chong S, Whitelaw E. Epigenetic germline inheritance. Curr Opin Genet Dev. 2004;14:692-6.

  16. Choong-Gu Lee, Anupama Sahoo, and Sin-Hyeog Im. Epigenetic Regulation of Cytokine Gene Expression in T Lymphocytes. Yonsei Med J. 2009 June30;50(3):322-30. Published online 2009 June 23. doi: 10.3349/ymj.2009.50.3.322

  17. De Carvalho DD, Sharma S, You JS, Su SF, Taberlay PC, Kelly TK et al. DNA methylation screening identifies driver epigenetic events of cancer cell survival. Cancer Cell .2012;21:655-67

  18. Delgado-Vega A, Sánchez E, Löfgren S, Castillejo-López C, Alarcón-Riquelme ME. Recent findings on genetics of systemic autoimmune diseases. Curr. Opin. Immunol. 2010;22:698-705

  19. DeWoskin VA, Million RP. The epigenetics pipeline. Nat Rev Dr Discovery. 2013;12:661-2. doi:10.1038/nrd4091

  20. Esteller, M. Cancer epigenomics: DNA methylomes and histone-modification maps. Nat. Rev. Genet. 2007;8:286-98.

  21. Farh KK, Marson A, Zhu J, Kleinewietfeld M, Housley WJ, Beik S et al. Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature. 2015;518: 337-43.

  22. Fatica A, Bozzoni I. Long non-coding RNAs: new players in cell differentiation and development. Nat Rev Genet. 2014;15:7-21

  23. Feinberg AP. Epigenomics reveals a functional genome anatomy and a new approach to common disease. Nature Biotechnology. 2010;28:1049-52.

  24. Fraga, M. F. et al. Epigenetic differences arise during the lifetime of monozygotic twins. Proc. Natl Acad. Sci. USA. 2005;102:10604-9.

  25. Gillespie J, Savic S, Wong C, Hempshall A, Inman M, Emery P et al. Histone deacetylases are dysregulated in rheumatoid arthritis and a novel histone deacetylase 3-selective inhibitor reduces interleukin-6 production by peripheral blood mononuclear cells from rheumatoid arthritis patients. Arthritis Rheum. 2012;64:418-22.

  26. Gillespie J, Savic S, Wong C, Hempshall A, Inman M, Emery P et al. Histone deacetylases are dysregulated in rheumatoid arthritis and a novel histone deacetylase 3-selective inhibitor reduces interleukin-6 production by peripheral blood mononuclear cells from rheumatoid arthritis patients. Arthritis Rheum. 2012;64:418–22.

  27. Girardot M, Feil R, Llères D. Epigenetic deregulation of genomic imprinting in humans: causal mechanisms and clinical implications. Epigenomics. 2013;5:715-2.8

  28. Girardot M, Feil R, Llères D. Epigenetic deregulation of genomic imprinting in humans: causal mechanisms and clinical implications. Epigenomics. 2013;5:715-28.

  29. Gray SG. Perspectives on epigenetic-based immune intervention for rheumatic diseases. Arthritis Res Ther. 2013;15:20-7.

  30. Grundberg, E. et al. Mapping cis- and trans-regulatory effects across multiple tissues in twins. Nat. Genet. 2012;12:1084-9.

  31. Hemmatazad H, Maciejewska Rodrigues H, Maurer B, Brentano F, Pileckyte M, Distler JH, et al. Histone deacetylase 7 – A potential target for the anti-fibrotic treatment of systemic sclerosis. Arthritis Rheum. 2009;60:1519-29.

  32. heng ASL, Li MS, Kang W, Cheng VY, Chou J-L, Lau SS. Helicobacter pylori causes epigenetic dysregulation of FOXD3 to promote gastric carcinogenesis. Gastroenterology. 2013;144: 122-33 e9

  33. Henikoff S. and Shilatifard A.. Histone modification: Cause or cog? Trends Genet. 2011;27:389-96.

  34. Hernández Fernández R. La expresión de la información genética En Introducción a la Genética Médica Lantigüa Cruz A [y otros].La Habana: Ed. Ciencias Médicas; 2004,27-41.

  35. Javierre BM, Richardson B. A new epigenetic challenge: systemic lupus erythematosus. Adv Exp Med Biol. 2011;711:117-36.

  36. Juvenal GJ. Epigenética: vieja palabra, nuevos conceptos. Revista Argentina de Endocrinología y Metabolismo. 2014;51(2): 66-74.

  37. Kaminsky, Z. A. et al. DNA methylation profiles in monozygotic and dizygotic twins. Nat. Genet. 2009;41:240-5.

  38. Khavari DA, Sen GL, Rinn JL. DNA methylation and epigenetic control of cellular differentiation. Cell Cycle. 2010; 9:3880-3,

  39. Knopik VS, Maccani MA, Francazio S, McGeary JE. The epigenetics of maternal cigarette smoking during pregnancy and effects on child development. Dev Psychopathol. 2012;24:1377-90.

  40. Lei W, Luo Y, Yan K, Zhao S, Li Y, Qiu X, et al. Abnormal DNA methylation in CD4+ T cells from patients with systemic lupus erythematosus, systemic sclerosis, and dermatomyositis. Scand J Rheumatol. 2009;38:369-74.

  41. Liu I, Li Y, Tollefsbol TO. Gene-environment interactions and epigenetic basis of human diseases. Curr Iss Mol Biol. 2008;10:25-36.

  42. Maciejewska-Rodrigues H, Jüngel A, Gay S. The Role of Epigenetics in Immune Disorders. Ann N Y Acad Sci. 2006;1069:322-45.

  43. Maciejewska-Rodrigues H, Karouzakis E, Strietholt S, Hemmatazad H, Neidhart M, Ospelt C, et al. Epigenetics and rheumatoid arthritis: the role of SENP1 in the regulation of MMP-1 expression. J Autoimmun. 2010;35:15-22.

  44. Maurano MT, Humbert R, Rynes E, Thurman RE, Haugen E, Wang H et al. Systematic localization of common disease-associated variation in regulatory DNA. Science. 2012;337:1190-5.

  45. Meda F, Folci M, Baccarelli A, Selmi C. The epigenetics of autoimmunity. Cell Mol Immunol. 2011;8(3):226-36. Published online 2011 Jan 31. doi: 10.1038/cmi.2010.78

  46. Nakamura C, Matsushita I, Kosaka E, Kondo T, Kimura T. Anti-arthritic effects of combined treatment with histone deacetylase inhibitor and low-intensity ultrasound in the presence of microbubbles in human rheumatoid synovial cells. Rheumatology (Oxford). 2008;47:418-24..

  47. Nakano K, Whitaker JW, Boyle DL, Wang W, Firestein GS. DNA methylome signature in rheumatoid arthritis. Ann Rheum Dis. 2013;72:110-7.

  48. Nassabeh N. Connective tissue diseases: is epigenetic modification the future of antifibrotic therapy? Nat RevRheumatol. 2009:354-6.

  49. Obata Y, Furusawa Y, Hase K. Epigenetic modifications of the immune system in health and disease. Immunology and Cell Biology. 2015;93:226–32. doi:10.1038/icb.2014.114; published online 10 February 2015

  50. Orru, V. et al. Genetic variants regulating immune cell levels in health and disease. Cell. 2013;155:242-56.

  51. Pallante P, Battista S, Pierantoni GM, Fusco A. Deregulation of microRNA expression in thyroid neoplasias. Nat Rev Endocrinol. 2014;10:88-101.

  52. Pan Y, Sawalha AH. Epigenetic regulation and the pathogenesis of systemic lupus erythematosus. Transl Res. 2009;153:4-10.

  53. Pease M, Ling C, Mack WJ, Wang K, Zada G. The role of epigenetic modification in tumorigenesis and progression of pituitary adenomas: a systematic review of the literature PLoS One. , 2013; 8:e82619

  54. Peterson LW, Artis D. Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Nat Rev Immunol. 2014;14:141-53.

  55. Picascia A, Grimaldi V, Pignalosa O, et al. Epigenetic control of autoimmune diseases: From bench to bedside. Clin Immunol. 2015;157(1):1-15.

  56. Runyon RS, Cachola LM, Rajeshuni N, Hunter T, Garcia M, Ahn R, Lurmann F, Krasnow R, Jack LM, Miller RL, Swan GE, Kohli A, Jacobson AC, Nadeau KC. Asthma discordance in twins is linked to epigenetic modifications of T cells. PLoS One. 2012;7:e48796

  57. Selmi C, Leung PS, Sherr DH, Diaz M, Nyland JF, Monestier M et Mechanisms of environmental influence on human autoimmunity. Environmental Health Sciences National Institute’s expert panel workshop. J Autoimmun. 2012;39:272-84.

  58. Seumois G, Chavez L, Gerasimova A, Lienhard M, Omran N, Kalinke L et al. Epigenomic analysis of primary human T cells reveals enhancers associated with TH2 memory cell differentiation and asthma susceptibility. Nat Immunol. 2014;15:777-88..

  59. Shankar S, Kumar D, Srivastava RK. Epigenetic modifications by dietary phytochemicals: implications for personalized nutrition. Pharmacol Ther. 2013;138:1-17.

  60. Shankar S, Kumar D, Srivastava RK. Epigenetic modifications by dietary phytochemicals: implications for personalized nutrition. Pharmacol Ther. 2013;138:1-1.7

  61. Shukla SD, Lim RW. Epigenetic effects of ethanol on the liver and gastrointestinal system. Alcohol Res. 2013;35:47-55.

  62. Shukla SD, Lim RW. Epigenetic effects of ethanol on the liver and gastrointestinal system. Alcohol Res. 2013;35:47-55.

  63. Stanczyk, J. et al. Altered expression of miR-203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activation. Arthritis Rheum. 2011; 63:373-81.

  64. Sun H, Kennedy PJ, Nestler EJ. Epigenetics of the depressed brain: role of histone acetylation and methylation. Neuropsychopharmacol. 2013;38:124-37.

  65. Sun H, Kennedy PJ, Nestler EJ. Epigenetics of the depressed brain: role of histone acetylation and

  66. methylation. Neuropsychopharmacology. 2013;38:124-37.

  67. Tollefsbol TO. Epigenetics: The New Science of Genetics.En En The molecular biology of gene. Watson JD, Gann A, Baker TA, Levine M, Michael TA, Bell S.P, Losick R, Harrison SC. 7ma Ed. California: Ed., Berkeley 2014. pg 672-93.

  68. Vedove CD, Del Giglio M, Schena D, Girolomoni G. Drug-induced lupus erythematosus. Arch Dermatol Res. 2009;301:99-105.

  69. Villagra A, Cheng F, Wang H-W, Suarez I, Glozak M, Maurin M. The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance. Nat Immunol. 2009;10:92-10.

  70. Vu-Phan D, Koenig RJ. Genetics and epigenetics of sporadic thyroid cancer. Mol Cel Endocrinol. 2013;57:225-39.

  71. Waddington CH. The epigenotype. Endevour. 1942;1:18-20.

  72. Watson J. D, Crick F. H. C.: Molecular Structure of Nucleic Acids. A Structure for Deoxyribose Nucleic Acid. Nature. 1953;171: 737-8.

  73. Weng N-P, Araki Y, Subedi K. The molecular basis of the memory T cell response: differential gene expression and its epigenetic regulation. Nat Rev Immunol. 2012;12:306-15.

  74. Widschwendter, M. et al .Cancer susceptibility: epigenetic manifestation of environmental exposures. Cancer J. 2007;13(1):9-16.




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