2015, Number 3
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Rev Cub de Reu 2015; 17 (3)
Course evaluation and evolution of uveitis in patients with rheumatic diseases
Ríos GBBE, Saldarriaga RLM, Carvalho SVC, Ponce LPCFB, Fragoso PPJ, Serra WJ, de Carvalho FC, Leitão AMN
Language: Portugués
References: 13
Page: 171-177
PDF size: 116.10 Kb.
ABSTRACT
Objective: analyze the course and the development of uveitis associated with many rheumatic diseases.
Methods: the authors conducted a retrospective study based on records Analysis of 37 patients with previous diagnosis of uveitis during the period from 2000 to 2008.
Results: the association uveitis-rheumatic disease was observed in 26 patients (70,3 %); the others 11 (29,7 %) had idiopathic uveitis. The most common diagnoses were Idiopathic Juvenile Arthritis (56,8 %) of the sample, followed by Idiopathic Uveitis (29,7 %) and Seronegative Spondyloarthritis (8,1 %). The most frequent way of onset was after the underlying disease (58,8 %) and the most frequent localization was anterior uveitis (70,3 %). A total of 57 affected eyes were evaluated. The authors observed association between positive antinuclear antibody (ANA) and the emergence of uveitis and the most patients with positive ANA developed complications (65,0 %). The most frequent complications were cataract (30,2 %) and posterior synechiae (13,7 %). It was observed that all patients using biologic agents presented complicated uveitis at some stage of the disease, what could be explained by greater severity of uveitis in patients who required the use of these drugs.
Conclusion: the characteristics of uveitis associated with rheumatic diseases in this study were similar to those found by other authors and they emphasize the importance of regular eye evaluation in rheumatic diseases.
REFERENCES
Jabs DA, Nussenblatt RB, Rosenbaum JT. Standardization of Uveitis Nomenclature (SUN) Working Group. Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop. Am J Ophthalmol. 2005;140:509-16.
He S, Li X, Chan N, Hinton DR. Review: Epigenetic mechanisms in ocular disease. Mol Vis. 2013;19:665-74.
Kalinina AV, de Boer JH, Byers HL, Coulton GR, Dekkers J, de Visser L, et al. Intraocular biomarker identification in uveitis associated with juvenile idiopathic arthritis. Invest Ophthalmol Vis Sci. 2013;54(5):3709-20.
Zagora SL, McCluskey P. Ocular manifestations of seronegative spondyloarthropathies. Curr Opin Ophthalmol. 2014;25(6):495-501.
Zierhut M, Heiligenhaus A, deBoer J, Cunningham ET, Tugal-Tutkun I. Controversies in juvenile idiopathic arthritis-associated uveitis. Ocul Immunol Inflamm. 2013;21(3):167-79.
Pleyer U, Hazirolan D, Winterhalter S, Stübiger N. Behçet's disease - ophthalmological and general aspects part I: etiology, pathogenesis and diagnostics. Ophthalmologe. 2012;109(11):1129-41.
Gouveia ED, Yamamoto JH, Abdalla M, Hirata CE, Kubo P, Olivalves E. Causas das uveítes em serviço terciário em São Paulo, Brasil. Arq. Bras. Oftalmol. 2004; 67:139-45.
Smith AJ, Mackensen F, Sen NH, Leigh JF, Watkins JS, Pyatetsky D, et al. Epidemiology and Course of Disease in Childhood Uveitis. Ophthalmology. 116(8),154451
Vitale AT, Graham E, de Boer JH. Juvenile idiopathic arthritis-associated uveitis: clinical features and complications, risk factors for severe course, and visual outcome. Ocul Immunol Inflamm.. 2013;21(6):478-85.
Gouveia EB, Elmann D, Morales de Ávila MS. Espondilite anquilosante e uveíte: revisão. Rev. Bras. Reumatol. 2012;52(5):749-56.
Harman LE, Margo CE, Roetzheim RG. Uveitis: the collaborative diagnostic evaluation. Am Fam Physician. 2014;90(10):711-6.
Candell CE, Goldsmith DP, Koehler MA, Bittar B, Rose CD, Ostrov BE, et al . Prevalence and Outcome of Uveitis in a Regional Cohort of Patients With Juvenile. Arthritis. The Journal of Rheumatology. 1997;24(10):2031-34.
Kasapçopur O, Yologlu N, Özyazgan Y, Ercan G, Çaliskan S, Sever L, et al. Uveitis and Anti Nuclear Antibody Positivity in Children with Juvenile Idiopathic Arthritis. Indian Pediatrics. 2004;41:1035-39.