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2015, Number S1

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RCAN 2015; 25 (S1)

On the urinary excretion of creatinine in states of kidney dysfunction

Badell MA, Bacallao MR

Language: Spanish
References: 27
Page: S131-S139
PDF size: 427.99 Kb.


ABSTRACT

Rationale: The state of the kidney function is determinant for the correct disposal of the end products of nitrogen metabolism. In chronic end-stage kidney (ESKD) patients, urinary creatinine excretion is usually diminished. This circumstance might affect the diagnostic usefulness of this indicator of the nutritional status and body composition. Objectives: To determine the possible association between the presence of kidney dysfunction and the urinary creatinine excretion rate. Study design: Retrospective, analytical. Study serie: Four-hundred and sixty-one (Males: 67.0%; Ages ≥ 60 years: 36.9%) chronic ESKD (Stage 3: Glomerular filtration rate between 30–59 mL.minute-1 1.73 m-2 of body surface) patients assisted at the Department of Kidney Physiopathology, “Dr. Abelardo Buch López” Institute of Nephrology (Havana City, Cuba) between the years 1996 and 2012. Material and method: Selected percentiles of urinary creatinine excretion were obtained from chronic ESKD patients according with sex and age. Found percentile distribution was then compared with that observed in 4,848 subjects with preserved kidney function (Glomerular filtration rate ≥ 60 mL.minute-1 1.73 m-2 of body surface). Results: Regardless of sex or age, urinary creatinine excretion was significantly lower in the chronic ESKD patient. Behavior of urinary creatinine excretion as seen with age might have been affected to a greater extent for the repercussion of the existing kidney damage. Conclusions: Urinary creatinine excretion is not useful as indicator of the nutritional status of individuals with chronic kidney disease given its erratic and unpredictable behavior, which impedes developing effective predictive models.


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