Díaz-Franco SD, Barraza-Cervantes AJ, Sosa-García JO

Language: Spanish
References: 25
Page: 170-177
PDF size: 239.99 Kb.

ABSTRACT

In the present, the developing countries have increased the demand of organ donations from brain-dead patients and Mexico is not the exception; in recent years since the figures have increased significantly according to data CENATRA. Moreover, its important to know and understand the pathophysiological changes that occur in the patient with brain death and according to the changes occur, interventions can be implemented to optimize the hemodynamic and metabolic status of these patients; as otherwise there can be provided an inadequate transanesthesic management, which can negatively impact during organ procurement and viability thereof, significantly affecting receptor morbidity and mortality. This review is aimed to anesthesiologists, intensivists and coordinators of organ donations, which specialties have more contact with patients with brain death.

REFERENCES

1. Consultado en septiembre 2014; http://www.cenatra.salud.gob.mx/interioir/trasplantes_estadisticas.html

2. Querevalú-Murillo W, Orozco-Guzmán R, Díaz-Tostado S. Mantenimiento del donante cadavérico en la Unidad de Terapia Intensiva. Rev Asoc Mex Med Crit y Ter Int. 2013;27:107-114.

3. Van Norman GA. Another matter of life and death: what every anesthesiologist should know about the ethical, legal, and policy implications of the non-heart-beating cadaver organ donor. Anesthesiology. 2003;98:763-773.

4. Wijdicks EF, Varelas PN, Gronseth GS, Greer DM; American Academy of Neurology. Evidence-based guideline update: determining brain death in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2010;74:1911-1918.

5. Anonymous. A definition of irreversible coma. Report of the ad hoc committee of the Harvard Medical School to examine the definition of brain death. JAMA. 1968;205:337-340.

6. Hinojosa R, Herruzo A, Escoresca Ortega A, Jiménez P. Evaluación y mantenimiento del donante cardíaco. Med Intensiva. 2009;33:377-384.

7. Anderson TA, Baker P. Anesthesic considerations in organ procurement surgery: a narrative review. Can J Anaesth. 2015;62:529-539.

8. McKeown DW, Bonser RS, Kellum JA. Management of the heartbeating brain-dead organ donor. British Journal of Anaesthesia. 2012;108:i96-i107.

9. Seller-Pérez G, Herrera-Gutiérrez ME, Lebrón-Gallardo M, Quesada-García G. Planteamientos generales para el mantenimiento del donante de órganos. Med Intensiva. 2009;33:235-242.

10. Bernat JL, Capron AM, Bleck TP, et al. The circulatory respiratory determination of death in organ donation. Crit Care Med. 2010;38:963-970.

11. Ullah S, Zabala L, Watkins B, Schmitz ML. Cardiac organ donor management. Perfusion. 2006;21:93-98.

12. Bugge JF. Brain death and its implications for management of the potential organ donor. Acta Anaesthesiol Scand. 2009;53:1239-1250.

13. Miñambres E, Rodrigo E, Ballesteros MA, et al. Impact of restrictive fluid balance focused to increase lung procurement on renal function after kidney transplantation. Nephrol Dial Transplant. 2010;25:2352-2356.

14. Mascia L, Pasero D, Slutsky AS, et al. Effect of a lung protective strategy for organ donors on eligibility and availability of lungs for transplantation: a randomized controlled trial. JAMA. 2010;304:2620-2627.

15. Cooper DK. Hormonal resuscitation therapy in the management of the brain-dead potential organ donor. Int J Surgery. 2008;6:3-4.

16. Novitzky D, Cooper DK, Reichart B. Hemodynamic and metabolic responses to hormonal therapy in brain-dead potential organ donors. Transplantation. 1987;43:852-854.

17. Totsuka E, Dodson F, Urakami A, et al. Influence of high donor serum sodium levels on early postoperative graft function in human liver transplantation: effect of correction of donor hypernatremia. Liver Transpl Surg. 1999;5:421-428.

18. Dupuis S, Amiel JA, Desgroseilliers M, et al. Corticosteroids in the management of brain-dead potential organ donors: a systematic review. Br J Anaesth. 2014;113:346-359.

19. Novitzky D, Cooper DK, Wicomb W. Hormonal therapy to the brain-dead potential organ donor: the misnomer of the “Papworth Cocktail”. Transplantation. 2008;86:1479.

20. Hefty TR, Cotterell LW, Fraser SC, Goodnight SH, Hatch TR. Disseminated intravascular coagulation in cadaveric organ donors: incidence and effect on renal transplantation. Transplantation. 1993;55:442-443.

21. De Hert SG, Turani F, Mathur S, Stowe DF. Cardioprotection with volatile anesthetics: mechanisms and clinical implications. Anesth Analg. 2005;100:1584-1593.

22. Elkins LJ. Inhalational Anesthesia for Organ Procurement: Potential Indications for Administering Inhalational Anesthesia in the Brain-Dead Organ Donor. AANA Journal ß August. 2010;4:293-299.

23. Antognini JF, Berg K. Cardiovascular responses to noxious stimuli during isoflurane anesthesia are minimally affected by anesthetic action in the brain. Anesth Analg. 1995;81:843-848.

24. Hashiguchi H, Morooka H, Miyoshi H, Matsumoto M, Koji T, Sumikawa K. Isoflurane protects renal function against ischemia and reperfusion through inhibition of protein kinases, JNK and ERK. Anesth Analg. 2005;101:1584-1589.

25. Fitzgerald RD, Hieber C, Schweitzer E, Luo A, Oczenski W, Lackner FX. Intraoperative catecholamine release in brain-dead organ donors is not suppressed by administration of fentanyl. Eur J Anaesthesiol. 2003;20:952-956.