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Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán

2015, Number 3

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Rev Biomed 2015; 26 (3)

Multifocal epithelial hyperplasia in three rural communities from Yucatán, México

Carrillo-Montiel JM, Conde-Ferráez L, Ayora-Talavera G, Puerto -Solís M, González-Losa MR

Language: Spanish
References: 19
Page: 133-138
PDF size: 304.51 Kb.


ABSTRACT

Introduction. Multifocal epithelial hyperplasia (MEH) is a disease of the oral mucosa that has been described mostly amongst ethnic groups of Latin America. DNA of human papillomavirus 13 and 32 have been reported in lesions.
Objective. To describe epidemiology and clinical characteristic of MEH in rural communities in Yucatan, Mexico.
Material and Methods. A prospective, descriptive and cross sectional study was conducted, oral clinical exploration was done to 525 children from 3 to 13 years in order to identify lesions of MEH. In addition oral samples were taken for viral detection, it was carried out by genomic amplification of HPV 13. Clinical and epidemiological information was requested to the mothers.
Results. MEH prevalence was 11.8% (62/525, 53% girls and 47% boys), reaching up to 15.5% in Kochol community; the most affected age group was 13 years old. The average evolution time was 17 months, 50% of the children with MEH had affected relatives in their families. Multiple lesions were found in 73%, mostly with smooth surface, 82% had lesions in the lower lip, 35% in the tongue. All samples were positive to HPV type 13, except for two that were inadequate for PCR.
Conclusions. MEH prevalence found is amongst the highest ever reported in literature. The etiological role of HPV type 13 is confirmed, and the familiar presentation.


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