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2013, Number 4

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Rev Cubana Invest Bioméd 2013; 32 (4)

Proton pump inhibitors and calcium homeostasis

Martí-Cabrera M, Marti-Masanet M, Ríos-Navarro C, Polo PM, Esplugues MJV

Language: Spanish
References: 52
Page: 431-444
PDF size: 194.71 Kb.


ABSTRACT

Background: The relationship between proton pump inhibitors (PPI) and the risk of osteoporosis and bone fractures is a topic of great interest in recent medical literature. PPI are first choice drugs for diseases evolving with an increase in acid secretion. Due to their growing prescription, their potential toxicity is periodically verified.
Objectives: The present review analyzes the physiopharmacological bases and limited clinical evidence of a potential relationship between continued administration of PPIs and the appearance of osteoporosis and bone fractures. Both conditions are related to calcium homeostasis, and their relevance in elderly patients is high, due to their poor general prognosis and disabling effects.


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