López PG, Juárez NF, Rojas GA, García AR

Language: Spanish
References: 22
Page: 29-34
PDF size: 52.59 Kb.

ABSTRACT

There are multiple regions in the chromosomes containing genes that contribute to the susceptibility for the development of asthma and allergic diseases. It is estimated that 35 to 75% of genetic factors are involved in the development of asthma. A strong correlation exists between the expression of specific genes and the increased activation of elements of the immune response found within the main histocompatibility complex (MHC). These genes are located in human chromosome 6. Some genes that contribute to codify proteins of the allergic response, located in chromosomes 5q, 11q, 12q and 13q have been identified. The alleles HLA-DRB1+ 0101 and DPN1, contain mostly peptides of Dermatophagoides pteronyssinus. A high incidence of HLA-DQ2 has been identified in Brazillian children with positive cutaneous test and RAST to D. pteronyssinus. More reports of our population are desirable.

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