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2015, Number 4

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AMC 2015; 19 (4)

Evasion of the immune response: a lesson from mycobacterium tuberculosis

Vázquez RN, Stwart LG, Quesada LL, Falcón AY

Language: Spanish
References: 31
Page: 419-427
PDF size: 377.21 Kb.


ABSTRACT

Background: in the last years, tuberculosis has re-emerged as a public health problem of paramount importance worldwide, in developed countries and in developing countries. The advances in the obtaining of vaccines and new more effective drugs depend to a great extent on the knowledge about the characteristics of the pathogen and about the mechanisms that it uses to evade the immune response and thus the effect of the vaccine.
Objective: to argue the evasion of the immune response caused by mycobacterium tuberculosis, based on some mechanisms recently discovered.
Methods: descriptors from the Medical Subject Headings and Health Sciences Descriptors were used to make a bibliographic review of 60 published articles. Thirty articles from the last decade were chosen to constitute the research. The decrease or absence of an adaptable cellular response in the primary infection by mycobacterium tuberculosis causes an uncontrollable growth of the bacillus in the lungs and a fall in the survival, being some factors involved in the pathogenesis and in the activation of the immune system.
Conclusions: this germ is able to modulate the responses of T helper cells or clusters of differentiation 4 and 8 through the reduction of the synthesis and creation of various types of cytokines as well as the inhibition and induction of different processes of the host cell. Interleukin 12 plays an important role in the regulation of the infection of this germ.


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