2015, Number 4
<< Back Next >>
AMC 2015; 19 (4)
Exogenous surfactant as treatment for lung massive atelectasis
Rodríguez MVS, Quiroz VO, Oliva CCM, Díaz CE
Language: Spanish
References: 12
Page: 374-380
PDF size: 418.66 Kb.
ABSTRACT
Background: atelectasis is a collapse state and shortness of breath in part or all of one lung. Once the diagnosis of bronchial collapse is established, the treatment must be directed towards the find of the cause of obstruction and the infection that is usually concomitant.
Objective: to use bronchoalveolar lavage with exogenous surfactant (Surfacen
®), along with respiratory physiotherapy as treatment.
Clinical case: the case of a sixteen-year-old female patient with a personal-pathological history of epilepsy since she was two years old is presented. The patient was under treatment with valproate sodium. She is admitted in the intensive care unit of "Dr. Eduardo Agramonte Piña" Pediatric Hospital. The patient is diagnosed clinically, radiologically and gasometrically as having respiratory distress syndrome of a direct pulmonary cause. On the fifth day of treatment the patient presented acute respiratory problems with sudden oxygenation fall and is diagnosed radiologically as having massive atelectasis of the left lung. She underwent a wide bronchoalveolar lavage with 9 % saline solution and then the instillation of exogenous surfactant in 100 mg doses diluted in 10 ml of water per injection administered intrabronchially twice a day. After the second bronchoalveolar lavage and the respiratory kinesiotherapy, the total expansion of the collapsed area and a notable improvement of the oxygenation parameters were achieved. The mechanical ventilation was moved five days after the complication. The patient kept a good subsequent progress.
Conclusions: the application of bronchoalveolar lavage with exogenous surfactant improved the oxygenation problem that causes massive atelectasis and allowed a rapid radiographic progress in the patient, as well as the decrease of the ventilatory parameters.
REFERENCES
Schindler MB. Treatment of atelectasis: where is the evidence? Crit Care. 2005 Aug;9(4):341-2.
Pasquina P, Merlani P, Granier JM, Ricou B. Continuous positive airway pressure versus noninvasive pressure support ventilation to treat atelectasis after cardiac surgery. Anesth Analg. 2004 Oct;99(4):1001-8.
Seurynck SL, Brown NJ, Wu CW, Germino KW, Kohlmeir EK, Ingenito EP, et al. Op-tical monitoring of bubble size and shape in a pulsating bubble surfactome-ter. J Appl Physiol. 2005 Aug;99(2):624-33.
Manzanares Tapia D, Díaz Casañas E, Al-fonso Lorenzo WC, Escobar Medina AC, Colomé Dagnesses H, Muñoz Pérez, MC, et al. Centro Nacional de Sanidad Agropecuaria. Surfactante pulmonar natural de origen porcino. Patente de la República de Cuba. A61K 35/42. 24 Dic 1997.
The Acute Respiratory Distress Syndrome Network. Ventilation wit lower tidal vol-umes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. New Engl J Med. 2000 May;342(18):1301-1308.
López-Herce Cid J, de Lucas Romero N, Carrillo Gamba A, Bustinza Ferrer A, Moral Maneiro R. Surfactant treatment for acute respiratory distress syndrome. Arch Dis Child. 1999 Mar;80(3):248-52.
Cereda M, Emami K, Xin Y, Kadlecek S, Ku-zma NN, Mongkolwisetwara P, et al. Imag-ing the Interaction of atelectasis and over-distention in surfactant-depleted lungs. Crit Care Med. 2013 Feb;41(2):527–535.
Dargaville PA, Copnell B, Mills JF, Haron I, Lee JK, Tingay DG, et al. Randomized con-trolled trial of lung lavage with dilute sur-factant for meconium aspiration syndrome. J Pediatr. 2011 Mar;158(3):383-9.
Szymankiewicz M, Gadzinowski J, Kowalska K. Pulmonary function after surfactant lung lavage followed by surfactant administra-tion in infants with severe meconium aspi-ration syndrome. J Matern Fetal Neonatal Med. 2004 Aug;16(2):125-30.
Been JV, Zimmermann LJ. What's new in surfactant? A clinical view on recent a de-velopments in neonatology and paediatrics. Eur J Pediatr. 2007 Sep;166(9):889-99.
Matina F, Collura M, Maggio MC, Vitulo P, Lo Piparo C, Corsello G. Inhaled surfactant in the treatment of accidental talc powder inhalation: a new case report. Ital J Pedi-atr. 2011 Sep; 37:47.
Blanco Hidalgo O, Cruz Rodríguez A, Ospina Ramírez OL, López Rodríguez E, Vázquez Martínez L, Pérez Gil J. Interfacial behavior and structural properties of a clinical lung surfactant from porcine source. Biochim Biophys Acta. 2012 Nov;1818(11):2756-66.