medigraphic.com
ISSN 1028-4796 (Print)

2015, Number 1

<< Back Next >>

Rev Cubana Plant Med 2015; 20 (1)

Toxicological profile of phases II and III of the extracted exudate Mangifera indica L. fruit

da Silva REH, Simões DH, Chávez JG

Language: Portugués
References: 36
Page: 75-87
PDF size: 149.24 Kb.


ABSTRACT

Introduction: the plants still represent an important source of raw material for making medicines. Despite the large number of plant species in Brazil, only a small portion has been adequately studied. Mangifera indica L, a member of the Brazilian flora, has important active substances in its various parts, although there is information in the literature on the effects of existing components in the exudate of the fruit peduncle, especially the spontaneous separation of phases.
Objective: evaluation of spontaneous responses in rat adults under the influence of the fractions II and II of the exudates from the stalk of the Mangifera indica fruit.
Methods: the exudate obtained from the stalk of M. indica fruits specimens obtained from the Campus UFRPE was provided. After a settling period of six days, four distinct phases were spontaneously seen. In phases two and three, after the separation and weighing processes, 0.5 mL aliquots were administered intraperitoneally in each animal, and the spontaneous activity was observed for 100 min.
compared with the control group, suggestive behavioral responses were observed such as tail up, difficulty of movement of the eyelids, itchy nose, hypnosis, shaking his head, sneezing reflex, prostration, walking dragging, stretching the body, itchy abdomen, scratching the eye and sedation. These responses presented characteristic time intervals for occurrence.
Conclusions: the responses suggested that important physiological mechanisms are appropriately triggered when the animals are under the effects of the chemical constituents included in the phase II and III. Based on further studies, lead to the discovery of new sources of natural active substances with important biological activity that can be applied in medicine.


REFERENCES

  1. Oliveira F, Akisue G. Fundamentos de farmacobotânica. 2ª ed. São Paulo: Editora Atheneu. 2003. 178 p.

  2. Guarrera MP. Traditional Phythoterapy in central Italia. Fitoterapia. 2005;76(1):1-25.

  3. Lorenzi H, Matos FJA. Plantas medicinais no Brasil: nativas e exóticas. Nova Odessa-SP: Instituto Plantarum. 2002;49-59.

  4. Filho WPC, Alves HS, Mazzei AR. Mercado de Manga no Brasil: contexto mundial, variedades e estacionalidade. Informações Econômicas. 2004;34(5):60-8.

  5. Cravo AB. Frutas e ervas que curam: usos, receitas e dosagens. Ed. HEMUS. São Paulo. 1995. p. 140.

  6. Maranca G. Fruticultura comercial, manga e abacate. 2ª. ed. São Paulo: Nobel S. A, 1976.

  7. Seifried HE, Anderson DE, Fisher EI, Milner JA. A review of the interaction among dietary antioxidants and reactive oxygen species. J Nutr Biochem. 2007;18(9):567-79.

  8. Diplock AT, Charleux JL, Crozier-Willi G, Kok FJ, Rice-Evans C, Roberfroid M, et al. Functional food science and defense against reactive oxidative species. Br J Nutr. 1998;80(1):S77-112.

  9. Aderibigbe AO, Emudianughe TS, Lawal BA. Evaluation of the antidiabetic action of Mangifera indica in mice. Phytother Res. 2001;15(1):456-8.

  10. Perpιtuo GF, Salgado JM. Effect of mango (Mangifera indica, L.) ingestion on blood glucose levels of normal and diabetic rats. J Plant Foods Hum Nutr. 2003;58(3):1-12.

  11. Zhu XM, Song JX, Huang ZZ, Whu YM, Yu MJ. Antiviral activity of mangiferin against herpes simplex virus type 2 in vitro. Zhongguo Yao Li Xue Bao. 1993;14(5):452-4.

  12. Zheng MS, Lu ZY. Antiviral effect of mangiferin and isomangiferin on herpes simplex virus. Chin Med J. 1990;103(2):160-5.

  13. Garcia D, Escalante M, Delgado R, Ubeira FM, Leiro J. Anthelminthic and antiallergic activities of Mangifera indica L. stem bark components Vimang and mangiferin. Phytother Res. 2003;17(10):1203-8.

  14. Rivera DG, Balmaseda IH, Leon AA, Hernandez BC, Montiel LM, Garrido GG, et al. Anti-allergic properties of Mangifera indica L. extract (Vimang) and contribution of its glucosylxanthone mangiferin. J Pharm Pharmacol. 2006;58(3):385-92.

  15. Perrucci S, Fichi G, Buggiani C, Rossi G, Flamini G. Efficacy of mangiferin against Cryptosporidium parvum in a neonatal mouse model. Parasitol Res. 2006;99(2):184-8.

  16. Muanza DN, Euler KL, Williams L, Newman DJ. Screening for antitumor and anti-HIV activities of nine medicinal plants from Zaire. Int J Pharmacol 1995;33(2):98.

  17. Aswal BS, Bhakuni DS, Goel AK, Kar K, Mehrota BN, Mukhrjee KC. Screening of Indian plants for biological activity: Part X. Indian J Exp Biol. 1984;22(6):312-32.

  18. Awe SO, Olajide OA, Oladiran OO, Makinde JM. Antiplasmodial and antipyretic screening of Mangifera indica extract. Phytother Res. 1998;12:437-8.

  19. Bidla G, Titanji VP, Jako B, Bolad A, Berzins K. Antiplasmodial activity of seven plants used in African folk medicine. Indian J Pharmacol. 2004;36(4):245-6.

  20. Sarkar A, Sreenivasan Y, Ramesh GT, Manna SK. beta-D-glucoside suppresses tumor necrosis factor-induced activation of nuclear transcription factor κappaB but potentiates apoptosis. J Biol Chem. 2004;279(32):33768-81.

  21. Manna SK, Kuo MT, Aggarwal BB. Overexpression of gamma-glutamylcysteine synthetase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappaB and activator protein-1. Oncogene. 1999;18(30):4371-82.

  22. Sairam K, Hemalatha S, Kumar A, Srinivasan T, Ganesh J, Sarkar M, et al. Evaluation of anti-diarrhoeal activity in seed extracts of Mangifera indica. J Ethnopharmacol. 2003;84(1):11-5.

  23. Das PC, Das A, Mandal S. Antiinflammatory and antimicrobial activities of the seed kernel of Mangifera indica. Fitoterapia. 1989;60(1):235-40.

  24. Garrido G, Gonzalez D, Delporte C. Analgesic and anti-inflammatory effects of Mangifera indica extract (Vimang). Phytother Res. 2001;15(1):18-21.

  25. Stoilova I, Gargova S, Stoyanova A, Ho L. Antimicrobial and antioxidant activity of the polyphenol mangiferin. Herb Polonica. 2005;51(3):37-44.

  26. Akinpelu DA, Onakoya TM. Antimicrobial activities of medicinal plants used in folklore remedies in south-western. Afr J Biotechnol. 2006;5(11):1078-208.

  27. Ramos EHS, Duarte HS, Jimenez GC. Análise toxicológica da fase I do exsudato extraído do fruto de Mangifera indica L. Revista Cubana de Plantas Medicinales. 2012;17(2):134-48.

  28. Agência Nacional de Vigilância Sanitária (ANVISA). Guia para a condução de Estudos não clínicos de segurança necessários ao desenvolvimento de medicamentos. Disponível em:www.anvisa.gov.br. Acessado em 10/06/2006.

  29. Griffith JF. Inter laboratory variations in the determination of acute oral LD50. Toxicology Applied Pharmacol. 1964;6(6):726-30.

  30. Hall F. Experimentals in mammalian. London: Spring-Verbuy; 1974. p. 276.

  31. Rosenkranz AC, Glacszpiegel R. Valorización de productos biológicos III (Validez de los ensayos biológicos). Safgbi. 1975;15:870.

  32. Oga I. Fundamentos de Toxicologia. 2ª ed. São Paulo, Brasil: Editora Atheneu; 2003.

  33. Silva P. Farmacologia do Sistema Nervoso Autônomo, Cap. 30, seção 1, Parte 2 Farmacologia Sistemática, em Farmacologia - 7ª Edição; Penildon Silva, Ed. Guanabara Koogan S. A.; R. J. 2006: 229-53.

  34. Craig CR, StitzeL RE. Introdução à Farmacologia do Sistema Nervoso Central. Cap. 24. 6ª. ed. Seção IV em Farmacologia Moderna com Aplicações Clínicas. Rio de Janeiro, Brasil: Editora Guanabara Koogan S. A.; 2005:263-71.

  35. Panizza S. Plantas que curam–cheiro de mato. 26ª ed. São Paulo: IBRASA, 2002. p. 11-146.

  36. Castro LO, Chemale VM. Plantas medicinais, condimentares e aromáticas - descrição e cultivo. Guaíba: Agropecuária, 1995. p. 9-10.




2020     |     www.medigraphic.com