Rebolledo-García D, Espay A, Espinoza GA, Contreras-Garduño S, Rebolledo-Rodríguez Z

Language: Spanish
References: 23
Page: 478-484
PDF size: 499.90 Kb.

ABSTRACT

Non Wilsonian hepatolenticular degeneration (Parkinsonism associated with cirrhosis of the liver) is a chronic encephalopathy with an engine extrapyramidal clinical spectrum due to dysfunction of basal ganglia in the context of severe liver disease. The diagnosis of the disease is underestimated by categorized within the spectrum of hepatic encephalopathy. There is evidence that the manganese deposits in the basal ganglia interfere with modulation of GABAergic and dopaminergic systems synergistically with ammonium glutamate leads to a state of neurodegeneration, with different pathophysiological idiopathic Parkinson’s disease.

REFERENCES

1. Robert S, Gerald B, Seegmiller J. Dietary protein in the genesis of hepatic coma. N Engl J Med 1954;251:685-687.

2. Newland CM. Animal models of manganese’s neurotoxicity. Neurotoxicology 1999;20:415-432.

3. Fernández-Rodríguez R, Contreras A, De Villoria JG, Grandas F. Acquired hepatocerebral degeneration: clinical characteristics and MRI findings. Eur J Neurol 2010;17:1463-1470.

4. Sheerin UM, Houlden H, Wood NW. Advances in the genetics of Parkinson’s disease: A guide for the clinician. Move Disorders 2014;1:3-14.

5. Butterworth RF. Metal toxicity, liver disease and neurodegeneration. Neurotoxicity Research 2010;18:100-105.

6. Maurice V, Raymond A, Monroe M. The acquired (no Wilsonian) type of chronic hepatocerebral degeneration. Medicine 1965;44:345-396.

7. Homburger F. Hepatolenticular degeneration —nutritional factors: observations on methionine and high-protein diets. N Engl J Med 1946;234:683-687.

8. Denny-Brown D. Hepatolenticular degeneration (Wilson’s disease) —two different components. N Engl J Med 1964;270:1149-1156.

9. Aschner M, Erikson KM, Herrero-Hernandez E, Tjalkens R. Manganese and its role in Parkinson’s disease: from transport to neuropathology. Neuromolecular Med 2009;11:252-266.

10. Calne DB, Chu NS, Huang CC, Lu CS, Olanow W. Manganism and idiopathic Parkinsonism: similarities and differences. Neurology 1994;44:1583-1586.

11. Jankovic J. Searching for a relationship between manganese and welding and Parkinson’s disease. Neurology 2005;64:2021-2028.

12. Guilarte TR, Chen MK. Manganese inhibits NMDA receptor channel function: implications to psychiatric and cognitive effects. Neurotoxicology 2007;28:1147-1152.

13. Fernsebner K, Zorn J, Kanawati B, Walkera A, Michalke B. Manganese leads to an increase in markers of oxidative stress as well as to a shift in the ratio of Fe(II)/(III) in rat brain tissue. Metallomics 2014;6:921.

14. Stanwood GD, Leitch DB, Savchenko V, Wu J, et al. Manganese exposure is cytotoxic and alters dopaminergic and GABAergic neurons within the basal ganglia. J Neurochem 2009;110:378-389.

15. Dong X, Wang Y, Qin Z. Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases. Acta Pharmacologica Sinica 2009;30:379-387.

16. Bowman AB, Kwakye GF, et al. Role of manganese in neurodegenerative diseases. J Trace Elem Med Biol 2011;25:191-203.

17. Liu X, Sullivan KA, Madl JE, Legare M, Tjalkens RB. Manganese- induced neurotoxicity: the role of astroglial-derived nitric oxide in striatal interneuron degeneration. Toxicol Sci 2006;91:521-531.

18. IKurniawan IT, Guitart-Masip M, Dolan RJ. Dopamine and effort-based decision making. Front Neurosci 2011;5:81.

19. Tryc BA, Berding G, Goldbecker A. Cirrhosis-related Parkinsonism: Prevalence, mechanisms and response to treatments. J Hepatol 2013;58:698-705.

20. Hong L, Jiang W, Pan H, et al. Brain regional pharmacokinetics of p-aminosalicylic acid and its N-acetylated metabolite: effectiveness in chelating brain manganese DMD 2011;39:1904-1909.

21. Stracciari, Baldin E, Cretella L, et al. Chronic acquired hepatocerebral degeneration: effects of liver transplantation on neurological manifestations. Neurol Sci 2011;32:411-415.

22. Guevara M, Baccaro ME, Gomez AB, et al. Cerebral magnetic resonance imaging reveals marked abnormalities of brain tissue density in patients with cirrhosis without overt hepatic encephalopathy. J Hepatol 2011;55:564-573.

23. Klos KJ, Ahlskog JE, Josephs KA, et al. Neurologic spectrum of chronic liver failure and basal ganglia t1 hyperintensity on magnetic resonance imaging. Probable manganese neurotoxicity. Arch Neurol 2005;62:1385-1390. doi:10.1001/archneur.62.9.1385.