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Colegio de Medicina Interna de México.

2015, Number 4

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Med Int Mex 2015; 31 (4)

Comparison of the efficacy of DPP- 4 inhibitors currently available and antihyperglycemic advantages of linagliptin in patients with diabetes mellitus type 2

Zúñiga-Guajardo S, Rodríguez-Gutiérrez R, Yamamoto-Cuevas J, Juárez-Comboni SC

Language: Spanish
References: 51
Page: 441-453
PDF size: 627.88 Kb.


ABSTRACT

Diabetes mellitus type 2 (DM2) is a disease whose pathogenesis involves multiple defects, a fact that has led to continue investigating drugs that may be able to correct these defects and improve glycemic control. As time, chronicity of diabetes mellitus type 2 is accompanied by a progressive decline in b cell function and disturbance in control of the α cells in pancreatic islets; accordingly, the drugs conventionally used to treat diabetic patients become less effective and exhibit gradually a large number of limitations, including the increased risk for hypoglycemia, increasingly prominent effects on body weight gain and the induction of gastrointestinal adverse events, edema and even heart failure. The development of new drugs, among which are inhibitors of the dipeptidyl peptidase type 4 (DPP-4) has revolutionized during the recent decade the treatment of type 2 diabetes, since these agents are effective in reducing glucose in a manner such that it is unlikely to produce hypoglycemia, and in animal models have been shown to prevent the progressive decline in b cell function and preserve insulin secretory capacity. Moreover, these drugs do not increase the risk for hypoglycemia nor body weight. These features make the DPP-4 suitable for long-term treatment of patients with diabetes mellitus type 2 agents. In this article efficacy for glycemic control of these new agents, either alone or in various therapeutic combinations, is analyzed. Furthermore, the efficacy, safety and tolerability of DPP-4 linagliptin, alone or in combination with metformin, insulin, sulfonylureas, glitazones are evaluated.


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