medigraphic.com
Órgano Oficial del Instituto Nacional de Pediatría

2015, Number 4

<< Back Next >>

Acta Pediatr Mex 2015; 36 (4)

Pancreatic encephalopathy, a case report

Chávez-Acosta KL, Lizárraga-López S, Zárate-Castañón P, García-Navarrete R

Language: Spanish
References: 43
Page: 337-346
PDF size: 744.39 Kb.


ABSTRACT

Pancreatic encephalopathy (PE) is an uncommon complication of acute pancreatitis. PE, one of multiple organ dysfunction syndromes; generally occurs in the early stage of severe acute pancreatitis and has a high mortality of 57%. We report a 16 years old female patient who presented neurological symptoms during an episode of acute pancreatitis. Other etiologies were discarded, and PE was considered. We discuss clinical and laboratorial factors associated with this complication. We also discuss about the role of pro-inflammatory molecules as neuromodulators within the central nervous system during the evolution of patients with acute pancreatitis.


REFERENCES

  1. Consuelo Sánchez A, García Aranda JA. Pancreatitis aguda. Bol Med Hosp Infant Mex 2012;69(1):3-10.

  2. Etxeberria Lekuona D, Pueyo Royo A, Edurne Arteche D. Pancreatitis Aguda. En libro Electrónico de Temas de Urgencias, Digestivas y Quirúrgicas. www.navarra.es/home_es/Temas/Portal+de+la+Salud/Profesionales/Documentacion+y+publicaciones/Otras+publicaciones/Libro+electronico+de+temas+de+urgencia/

  3. Cerda Cortaza L. Análisis de las nuevas clasificaciones de la pancreatitis aguda. Cirujano General 2013;35(Supl.1):16-17.

  4. Lautz TB, Chin AC, Radhakrishnan J. Acute pancreatitis in childen: spectrum of disease and predictors of severity. J PediatricSurgery 2011;46(6):1149-9.

  5. Casal L, Meana J, Karatanasópuloz C. Pancreatitis Aguda: Revisión. Revista de Posgrado de la VI cátedra de medicina 2002;112:5-20.

  6. Vera O. Manejo y tratamiento de la pancreatitis aguda en la unidad de cuidados intensivos. Artículo de revisión. Rev Med 2011;17:47-59.

  7. Marruecos SL. Pancreatitis aguda. Med Clin 1992;98:694-98.

  8. Mayer AD, Marshall J. Acute Pancreatitis. New England J Med 1985;312:399-404.

  9. Law NM, Freeman ML. Emergency Complications of Acute and Chronic Pancreatitis. Gastroenterology Clinics of North America 2003;32:1169-1194.

  10. Sharf B, Bental E. Boon E. Pancreatic encephalopathy. Journal of Neurology 1991;34:357-361.

  11. Qian ZY, Miao Y. Therapeutic strategy for severe acute pancreatitis and pancreatic encephalopathy. Zhonghua Wai Ke Za Zhi 2007;45(11):740-1.

  12. Ospina Nieto J, López Moncayo H. Pancreatitis Aguda: diez preguntas por responder. Asociación Colombiana de Cirugía, guías de manejo en cirugía. Bogotá, d.c. 2008;45:12-15.

  13. Uribe U, Arana Ch, Lorenzana P. Fundamentos de Medicina – Neurología. 2002. Editor Medellin, Colombia: Corporación para Investigaciones Biológicas, 2002: pp. 432-5.

  14. Sharf B, Bental E. Pancreatic encephalopathy. Journal of Neurology 1991;34:357-361.

  15. Ampo K, Suzuki A, Konishi H, Kiyama H. Induction of Pancreatitis-Associated Protein (PAP) Family Members in Neurons after Traumatic Brain Injury. Journal of neurotrauma 2009;26:1683–1693.

  16. Boon P, Reuck de J, Achten E, De Bleecker J. Pancreatic encephalopathy a case report and review of the literature. Clinical Neurology and Neurosurgery 1991;93: 1116-1118.

  17. McEwan DJ. TNF receptor subtype signaling: differences and cellular consequences. Cell Signal 2002;14:477–492.

  18. Barone FC, Arvin B, White RF, Miller A, Webb CL, Willette RN. Tumor necrosis factor-alpha. A mediator of focal ischemic brain injury. Stroke 1997;28:1233–1244.

  19. Lenzlinger PM, Morganti-Kossmann MC, Laurer HL, McIntosh TK. The duality of the inflammatory response to traumatic brain injury. Mol Neurobiol 2001;24:169–181.

  20. Sriram K, O'Callaghan JP. Divergent roles for tumor necrosis factor-alpha in the brain. J. Neuroimmune Pharmacol 2007;2:140–153.

  21. Pickering M, O'Connor JJ. Pro-inflammatory cytokines and their effects. Prog Brain Res 2007;163:339–354.

  22. Botchkina GI, Meistrell III ME, Botchkina IL, Tracey KJ. Expression of TNF and TNF receptors (p55 and p75) in the rat brain after focal cerebral ischemia. Mol Med 1997;3:765–781.

  23. Ravizza T, Gagliardi B, Noé, F, Boer K, Aronica E, Vezzani A. Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy. Neurobiol Dis 2008;29:142–160.

  24. Schafers M, Sorkin L. Effect of cytokines on neuronal excitability. Neuroscience Lett 2008;437:188–193.

  25. Viviani B, Gardoni F, Marinovich M. Cytokines and neuronal ion channels in health and disease. Int Rev Neurobiol 2007;82:247–263.

  26. Balosso S, Ravizza T, Aronica E, Vezzani A. The dual role of TNF-α and its receptors in seizures. Exp Neurol 2013;247:267-71.

  27. Zhang XP, Tian H. Pathogenesis of pancreatic encephalopathy in severe acute pancreatitis. Hepatobiliary Pancreat Dis Int 2007;6(2):134-40.

  28. Casas JD, Diaz R, Valderas G, et al. Prognostic value of CT in the early assessment of patients with acute pancreatitis. Am J Roentgenol 2004;182(3):569-574.

  29. Balosso S, Ravizza T, Aronica E, Vezzani A. The dual role of TNF-α and its receptors in seizures. Exp Neurol 2013;247:267-71.

  30. Banfi A. Encephalitis: Which are and how to treat? Rev Chil Infect 2003;20(1):S28-S33.

  31. Ruiz M, Santana C. Enfoque práctico para el diagnóstico de los errores congénitos del metabolismo. Acta Pediátrica Española 1998;(56):39-52.

  32. Campistol J. congenital errors of metabolism with epileptic seizures during the first years of life. Rev neurol 2002;35:S3-S20.

  33. Martin E. García M. Enfermedades congénitas del metabolismo en el periodo neonatal (I). Generalidades. Acta Pediatr Esp 2006;64(8):391-395.

  34. Arrollo H, Fernández M. Tóxicos ambientales y su efecto sobre el neurodesarrollo. Medicina (Buenos Aires) 2013;73(1):93-102.

  35. Nava C, Méndez M. Efectos neurotóxicos de metales pesados (cadmio, plomo, arsénico y talio). Arch Neurociencias Mex 2011;(16):140.

  36. Gaona V. Cefaleas por hipertensión intracraneana. Rev Med Hondur 2014;82(2):1-108.

  37. Betancourt Y, Jiménez B. Pseudotumor cerebral pediátrico. Rev Neurol 2006;42(3):S67-S73.

  38. Ortega A, Romero F. Tumores del sistema nervioso central en la infancia: aspectos clinicopatológicos. Rev Neurol 2004;38(6):554-564.

  39. Hidalgo A. Pancreatitis Aguda y sus complicaciones. Caracas: UCV., Consejo de Desarrollo Científico y Humanístico, 2006. pp. 55-56.

  40. Gil Lemus L, Sarmiento Suárez M. Psicosis inducida por esteroides. Revista colombiana de psiquiatría 2007;(36):542-550.

  41. Vieitez J. Calleja S. Protocolo diagnóstico y terapéutico de la neurotoxicidad por citostáticos. Encycl Méd Chir 2001;3117–3122.

  42. Coeffic D, Antoine E, Khavat D. Quimioterapia antitumoral. Encycl Méd Chir 2002;(6):2,1–7.

  43. Cano I, Enríquez N. Tumores de fosa posterior en pacientes pediátricos y su correlación clínica, radiológica y anatomopatológica. Anales de radiología México 2010;4:185-205.




2020     |     www.medigraphic.com