medigraphic.com
ISSN 1561-3119 (Electronic)

2015, Number 3

<< Back Next >>

Rev Cubana Pediatr 2015; 87 (3)

Vitamin A deficiency in children with cystic fibrosis

Portuondo LR, Macías MC, Abreu SG, Fuentes FG, González VJA

Language: Spanish
References: 22
Page: 318-326
PDF size: 168.74 Kb.


ABSTRACT

Introduction: subclinical Vitamin A deficiency is common in children and adolescents with cystic fibrosis of multifactoral origin; it influences the pulmonary deterioration and casts a shadow over the disease prognosis.
Objective: to characterize the state of this vitamin in children and adolescents with cystic fibrosis and its association with the nutritional status and with some clinical variables.
Methods: a cross-sectional and descriptive study was conducted in younger than 18 years-old children. They were seen at the multidisciplinary service of Centro Habana pediatric hospital, and received daily Vitamin A supplements as part of dietary recommendations; they were stable with no symptoms of shortage at the time of study. A high resolution chromatography evaluated the level of serum retinol, whose values, according to WHO standards, were considered normal when yielding 30-79 µg/dL, marginal from 20 to less than 30 µg/dL and subclinical deficiency ranging from 10 to lower than 20 µg/dL. The nutritional status was measured as body mass index percentiles of the Cuban population by decimal age and sex. Additionally, the patients were classified on the basis of reported mutation, pancreatic deficiency and typical pulmonary disease pursuant to the medical histories.
Results: in the sample, the 508F mutation (2 homozygotic and 6 heterozygotic) and typical disease with pancreatic disease (10) prevailed. Seven children (63.2 %) had low Vitamin A levels (4 marginal and 3 deficient), being low weighed children (80 vs. 50 % in the eutrophic ones), preschool children (2 out of 2) and adolescents (3 out of 5) predominant.
Conclusions: it is important to monitor Vitamin A in the follow-up of patients with cystic fibrosis.


REFERENCES

  1. Morton A. Why bother to take vitamins? J R Soc Med. 2011;104:S19-S29.

  2. Macias C, Basabe B, Cabrera A. Vitamina A y salud materno-infantil. Manual de capacitación para el equipo de salud. Instituto de Nutrición e Higiene de los Alimentos. La Habana: Molinos Trade SA; 2013.

  3. Sinaasapel M, Stern M, Littlewoods J, Wolfe S, Steinkamp G, Harry G, et al. Nutrition in patients with cystic fibrosis: a European Consensus. Journal of Cystic Fibrosis. 2002;1:51-75.

  4. Estévez-Santiago R, Beltrán-de-Miguel B, Cuadrado-Vives C, Olmedilla-Alonso B. Software application for the calculation of dietary intake of individual carotenoids and of its contribution to vitamin A intake. Nutr Hosp. 2013;28(3):823-9.

  5. Hector A, Griese M, Hartl D. Oxidative stress in cystic fibrosis lung disease: an early event, but worth targeting? Eur Respir J. 2014;44:17-9.

  6. Muñoz M, Pérez C, Bermejo T. Avances en el conocimiento del uso de micronutrientes en nutrición artificial. Nutr Hosp. 2011;26(1):37-47.

  7. Robinson P. Cystic fibrosis. Other clinical manifestations. In: Taussig LM, Landau LI, editor. Pediatric Respiratory Medicine. 2nd ed. Philadelphia: Mosby Elsevier; 2008. p. 889-905.

  8. Nasr SZ, Drury D. Appetite stimulants use in Cystic Fibrosis. Pediatric Pulmonology. 2008;43:209-19.

  9. Sánchez I, Pérez MA, Boza ML, Lezana V, Vila MA, Repetto G, et al. Consenso nacional de fibrosis quística. Rev Chil Pediatr [serie en Internet]. 2001 [citado 22 de mayo de 2014];72(4). Disponible en: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0370- 41062001000400013&lng=en&nrm=iso&tlng=en

  10. Esplugas AE, Razón R, Ojea A. Evaluación nutricional dietética en pacientes afectos de fibrosis quística. Rev Cubana Pediatr [serie en Internet]. 2008 [citado 10 de abril de 2014];80(3). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034- 75312008000300003&lng=es&nrm=iso&tlng=es

  11. Haack A, Garbi MR. Multidisciplinary care in cystic fibrosis; a clinical-nutrition review. Nutr Hosp. 2012;27(2):362-71.

  12. Salesa Y, Rebollo MJ. Manejo Nutricional en Niños y Adolescentes con Fibrosis Quística. Rev Chil Pediatr. 2009;80(3):274-84.

  13. Obeid M, Price J, Sun L, Scantlebury MH, Overby P, Sidhu R, et al. Facial Palsy and Idiopathic Intracranial Hypertension in Twins With Cystic Fibrosis and Hypovitaminosis A. Pediatric Neurology. 2011;44(2):150-2.

  14. Rana M, Wong-See D, Katz T, Gaskin K, Whitehead B, Jaffe A, et al. Fat-soluble vitamin deficiency in children and adolescents with cystic fibrosis. Journal of Clinical Pathology. 2014;67(7):605-8.

  15. Martínez-Costa C, Escribano A, Núñez F, García-Maset L, Luján J, Martínez- Rodríguez L. Intervención nutricional en niños y adolescentes con fibrosis quística. Relación con la función pulmonar. Nutr Hosp. 2005;20(3):182-8.

  16. Olveira G, Olveira C. Nutrición, fibrosis quística y aparato digestivo. Nutr Hosp. 2008;23(supl 2):71-86.

  17. Fielbaum O. Avances en fibrosis quística. Rev Med Clin Condes. 2011;22(2):150-9.

  18. Rojo M. Fibrosis Quística o mucoviscidosis. En: Autores Cubanos. Pediatría. Tomo III. La Habana: Editorial Ciencias Médicas; 2007. p. 1012-54.

  19. Sagel SD, Sontag MK, Anthony MM, Emmett P, Papas KA. Effect of an antioxidant-rich multivitamin supplement in cystic fibrosis. Journal of Cystic Fibrosis. 2011;10(1):31-6.

  20. Mora I, Orejas G, Bousoño C, Cué R, Ramos E, Crespo M. Valoración del estado nutricional en un grupo de pacientes con fibrosis quística. An Esp Pediatr. 1996;44:40-4.

  21. Olveira G, Acosta E, Olveira C. Nutrición y fibrosis quística: papel de la suplementación dietética en ácidos grasos. Nutr Clin Med. 2007;1(1):41-53.

  22. Souza dos Santos MI, Drehmer M, de Abreu e Silva FA, Hoffman A, Druck C, de Fonseca E, et al. Association of nutritional status, plasma, albumin levels and pulmonary function in cystic fibrosis. Nutr Hosp. 2011;26(6):1322-7.




2020     |     www.medigraphic.com