2000, Number 2
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Rev Inst Nal Enf Resp Mex 2000; 13 (2)
Fibrinolysis with microdose of streptokinase in pulmonary thromboembolism. Report of three cases
Baltazares LME, Vargas CR, Aboitiz RC, García LMP, Villalba CJ
Language: Spanish
References: 22
Page: 118-116
PDF size: 386.06 Kb.
ABSTRACT
We present three patients with acute pulmonary thromboembolism, no less than 25% occlusion of the vascular bed, hemodynamically stable, treated with the fibrinolytic agent streptokinase. Loading dose was 250 000 IU/h and maintenance dose 25 000 IU/h during 18 to 24 h. An angiography was practiced and the hemodynamic parameters were registered pre- and post-treatment. Almost total reperfusion of the affected sites was observed and the hemodynamic alterations secondary to the massive pulmonary embolism were mild.
REFERENCES
Hirsh J, Hoak J. Management of deep vein thrombosis and pulmonary embolism. Circulation 1996; 93:2212-2237.
Dalen JE, Alper JS. Natural history of pulmonary embolism. Prog Cardiovasc Dis 1975; 17:259-270.
Moser KM, Auger WR, Fedullo PF. Chronic major-vessel thromboembolic pulmonary hypertension. Circulation 1990; 18:1735-1743.
Lilienfeld DE, Chan E, Ehlane J, Godbold JH, Landrigane PJ, Marsh G. Mortality from pulmonary embolism in the United States: 1962 to 1984. Chest 1990; 98: 1067-1072.
Janata SK, Weiss K, Riezinger I, Bankier A, Domanovits H, Seidler D. Pulmonary embolism. II Diagnosis and treatment. Semin Thromb Hemost 1996; 22:33-52.
Lindblad B, Sternby NH, Bergqvist D. Incidence of venous thromboembolism verified by necropsy over 30 years. BMJ 1991; 302:709-711.
Goldhaber SZ. Thrombolysis for pulmonary embolism. Prog Cardiovasc Dis 1991; 34:113-134.
Konstantinides S, Geibel A, Olschewski M, Heinrich F, Grosser K, Rauber K, et al. Association between thrombolytic treatment and the prognosis of hemodynamically stable patients with major pulmonary embolism. Results of a multicenter registry. Circulation 1997; 3:882-888.
Ribeiro A, Lindmarker P, Johnson H, Dannfelt AJ, Jorfeldt L. Pulmonary embolism: One-year follow-up with echocardiography doppler and five-year survival analysis. Circulation 1999; 99:1325-1330.
Hyers TM, Agnelli G, Hull RD, Weg JG. Antithrombotic therapy for venous thromboembolic disease. Chest 1998: 114:561S-578S.
Goldhaber SZ, Agnelli G, Levine MN. Reduced dose bolus alteplase vs conventional alteplase infusion for pulmonary embolism thrombolysis. Chest 1994; 106:718-724.
Hyers TM, Hull RD, Weg JG. Antithrombotic therapy for venous thromboembolic disease. Chest 1992; 102:408S-421S.
Viner SM, Bagg BR, Auger WR, Ford GT. The management of pulmonary hipertension secondary to chronic thromboembolic disease. Prog Cardiovasc Dis 1994; 37:79-92.
Goldhaber S. Pulmonary embolism thrombolysis. Circulation 1997; 96:716-718.
Goldhaber SZ. Thrombolytic therapy. Adv Internl Med 1999; 44:311-325.
Schmitz-Rode T, Janssens U, Schild HH, Basche S, Hanrath P, Gunther RW. Fragmentation of massive pulmonary embolism using a pigtail rotation catheter. Chest 1998; 114:1427-1436.
Leeper VK, Popovich J, Lesser BA, Adams D, Froelich JW, Burke MW, et. al. Treatment of massive acute pulmonary embolism. The use of low doses of intrapulmonary arterial streptokinase combined with full doses of systemic heparin. Chest 1988;93:234-240.
Edwards IR, MacLean KS, Dow JD. Low-dose urokinase in major pulmonary embolism. Lancet 1973;2:409-413.
Meyer G, Gisselbrecht M, Diehl JL, Journois D, Sors H. Incidence and predictors of major hemorrhagic complications from thrombolytic therapy in patients with massive pulmonary embolism. Am J Med 1998;105:472-477.
Landefeld CS, Anderson PA, Goodnough LT, Moir TW, Hom DL, Rosenblatt MW, et al. The bleeding sverity index: Validation and comparison to the methods for classifying bleeding complications of medical therapy. J Clin Epidemiol 1989; 42:711-718.
More RS, Chauhan A. Pulmonary embolism: The role of thrombolytic therapy in its management. Postgrad Med J 1996;72:157-161.
Stein PD. Anticoagulant and antithrombotic therapy in deep venous thrombosis and pulmonary embolism. Henry Ford Hosp Med J 1988;36:35-40.