medigraphic.com
ISSN 1870-2821 (Print)
Organo Oficial de la Asociación Mexicana de Mastología

2015, Number 1

<< Back Next >>

Rev Mex Mastol 2015; 5 (1)

Breast cancer in young women. Experience at the National Cancer Institute

Villarreal-Garza C, Platas A, Bargalló-Rocha JE, Lasa F, Reynoso N, Águila-Mancera C, Shaw-Dulin R, Arce-Salinas C, Lara-Medina F, Martínez-Cannon BA, Mohar-Betancourt A

Language: Spanish
References: 18
Page: 12-17
PDF size: 284.91 Kb.


ABSTRACT

Breast cancer in young women has a high prevalence in the National Institute of Cancerology (INCan), corresponding to 15% of the total number of patients attended at this Institution. More than 80% of the patients from this age group present advanced stage disease, and triple negative and HER2-positive subtypes are more frequent than in their older counterparts. The results of studies done by our group suggest that the poor survival associated with young age is not only due to the greater proportion of triple negative and HER2-positive breast cancer, but also to the poor prognosis in the most prevalent hormone-sensitive, HER2-negative subtype. On the other hand, the diagnosis and treatment of this young group have particular repercussions that were demonstrated in a qualitative study done with surviving young Mexicans. Due to the lack of attention to the current needs of young women in Mexico and the majority of low and middle socioeconomic status, the Program for Attention and Research for Young Women with Breast Cancer, was created at the INCan in 2013. Recently, a second site was incorporated at the Hospital San Jose and in the near future we expect to expand this model of care to other centers nationally and in Latin America.


REFERENCES

  1. Knaul FM, Nigenda G, Lozano R, Arreola-Ornelas H, Langer A, Frenk J. Breast cancer in Mexico: a pressing priority. Reprod Health Matters. 2008; 16 (32): 113-123.

  2. Rodríguez-Cuevas S, Macías-Martínez CG, Labastida-Almendaro S. Breast cancer in Mexico. Is it a young women disease? Ginecol Obstet Mex. 2000; 68: 185-190.

  3. Lara-Medina F, Pérez-Sánchez V, Saavedra-Pérez D et al. Triple-negative breast cancer in Hispanic patients: high prevalence, poor prognosis, and association with menopausal status, body mass index, and parity. Cancer. 2011; 117 (16): 3658-3669.

  4. American Cancer Society. Breast cancer facts & figures 2011-2012. Atlanta, Georgia: American Cancer Society; 2011 [Accessed May 14, 2013]. Available in: http://www.cancer.org/acs/groups/content/@epidemiologysurveilance/documents/document/acspc-030975.pdf.

  5. Partridge AH, Ruddy KJ, Kennedy J, Winer EP. Model program to improve care for a unique cancer population: young women with breast cancer. J Oncol Pract. 2012; 8 (5): e105-110.

  6. Ali A, Warner E. Pynk: breast cancer program for young women. Curr Oncol. 2013; 20 (1): e34-e39.

  7. Adami HO, Malker B, Holmberg L, Persson I, Stone B. The relation between survival and age at diagnosis in breast cancer. N Engl J Med. 1986; 315 (9): 559-563.

  8. Love RR, Duc NB, Dinh NV, Quy TT, Xin Y, Havighurst TC. Young age as an adverse prognostic factor in premenopausal women with operable breast cancer. Clin Breast Cancer. 2002; 2 (4): 294-298.

  9. Gnerlich JL, Deshpande AD, Jeffe DB, Sweet A, White N, Margenthaler JA. Elevated breast cancer mortality in women younger than age 40 years compared with older women is attributed to poorer survival in early-stage disease. J Am Coll Surg. 2009; 208 (3): 341-347.

  10. Walker RA, Lees E, Webb MB, Dearing SJ. Breast carcinomas occurring in young women (< 35 years) are different. Br J Cancer. 1996; 74 (11): 1796-1800.

  11. Anders CK, Hsu DS, Broadwater G et al. Young age at diagnosis correlates with worse prognosis and defines a subset of breast cancers with shared patterns of gene expression. J Clin Oncol. 2008; 26 (20): 3324-3330.

  12. Xiong Q, Valero V, Kau V et al. Female patients with breast carcinoma age 30 years and younger have a poor prognosis: the M.D. Anderson Cancer Center experience. Cancer. 2001; 92 (10): 2523-2528.

  13. Villarreal-Garza C, Magallanes-Hoyos C, Meza V et al. Pathological characteristics and patterns of recurrence and mortality among Mexican young breast cancer patients. SABCS 2013; 2013.

  14. Villarreal-Garza C, Reynoso-Noveron N, Arce-Salinas C et al. Abstract P6-08-55: High triple-negative breast cancer prevalence and poor outcome of hormone receptor positive breast cancer among young Mexican women. Cancer Research [Internet]. 2015; 75 (9 Supplement). Available in: http://cancerres.aacrjournals.org/content/75/9_Supplement/P6-08-55.abstract):P6-08-55.

  15. Villarreal-Garza CM, Arce-Salinas C, Lasa F et al. Outcome of neoadjuvant-treated young patients with hormone receptor-positive breast cancer. J Clin Oncol. 2015; 33 (Suppl; abstr e11577). Available in: http://meeting.ascopubs.org/cgi/content/abstract/33/15_suppl/e11577):e11577.

  16. Partridge AH, Ruddy KJ. Fertility and adjuvant treatment in young women with breast cancer. Breast. 2007; 16 Suppl 2: S175-181.

  17. Fobair P, Stewart SL, Chang S, D’Onofrio C, Banks PJ, Bloom JR. Body image and sexual problems in young women with breast cancer. Psychooncology. 2006; 15 (7): 579-594.

  18. Cardoso F, Bese N, Distelhorst SR et al. Supportive care during treatment for breast cancer: resource allocations in low- and middle-income countries. A Breast Health Global Initiative 2013 consensus statement. Breast. 2013; 22 (5): 593-605.




2020     |     www.medigraphic.com