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2014, Number 4

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Rev Cubana Plant Med 2014; 19 (4)

Toxicity of chemical compounds of anorexic action extracted from Garcinia cambogia (garcinia) and Panax ginseng (ginseng)

Mousinho L, Pinheiro FPM, Carvalho MC, Peron AP

Language: Portugués
References: 56
Page: 280-291
PDF size: 119.49 Kb.


ABSTRACT

Introduction: difficulty in adopting healthy eating habits, a sedentary lifestyle and the wish to lose weight easily, lead to the search for methods that promote weight loss effortlessly using drugs containing hydroxycitric acid (HCA) extracted from Garcinia cambogia (garcinia) and ginsenosides extracted from Panax ginseng (ginseng). However, information on the potential toxicity of these chemical products is not widely available, though they are present in a weight-loss drug which is sold freely and used indiscriminately in Brazil.
Objective: compile the results of the main toxicological studies on these two anorexic compounds.
Methods: a broad bibliographic search was conducted in important indexed databases.
Results and discussion: it was found that several studies on the topic have been performed, but further research is required using other test organisms and different doses. It was also found that the results so far obtained are contradictory, thus constituting a subject of debate among researchers.
Conclusions: it is necessary to increase the number of studies evaluating the toxic effects of these compounds manufactured for the market, establishing limits for their use by the population.


REFERENCES

  1. Delavar M, Lye M, Hassan S, Khor G. Physical activity, nutrition and dyslipidemia in middle-aged women. Iran J Public Health. 2011;40(4):89-98.

  2. Yadav A, Jyoti P, Jain SK, Bhattacharjee J. Correlation of adiponectin and leptin with insulin resistence a pilot study in healthy north Indian population. Indian J of Clin Biochem. 2011;26(2):193-6.

  3. Márquez F, Babio N, Bulló M, Salas-Salvadó J. Evaluation of the safety and efficacy of hydroxycitric acid or Garcinia cambogia extracts in humans. Crit Rev Food Sci and Nutr. 2012;52(7):585-594.

  4. Avelar-Escobar G, Méndez-Navarro J, Ortiz-Olvera NX, Castellanos G, Ramos R, Gallardo-Cabrera VE, et al. Hepatotoxy associated with dietary energy supplements use and abuse by young athletes. Ann Hepatol. 2012;11(4):564-9.

  5. Hambre D, Vergara M, Lood Y, Bacharah-Lindstrom M, Lindstrom T, Nystrom FH. A randomized trial of protein supplementation compared with extra fast food on the effects of resistance training to increase metabolism. Scand J Clin and Lab Invest. 2012;72(6):471-8.

  6. Reis MS, Nascimento ES. Informações toxicológicas de alguns fitoterápicos utilizados no Brasil. Rev Bras de C Farmacêuticas. 2006;42(2):289-306. [citado agosto 2013]. Disponível em: http://www.scielo.br/scielo.php?script=sci_issuetoc&pid=1516- 933220060001&lng=es&nrm=iso

  7. Veiga-Junior VF. Estudo do consumo de plantas medicinais na Região Centro- Norte do Estado do Rio de Janeiro: aceitação pelos profissionais de saúde e modo de uso pela população. Braz J Pharmacognosy. 2008;18(2):308-13.

  8. Menghini L, Epifano F, Leporini L, Pagiotti R, Tirillini B. Phytochemical investigation on leaf extract of Cordia salicifolia Cham. J Med Food. 2010;11(1):193-4.

  9. Rosenkranz RR. Service-learning in higher education relevant to the promotion of physical activity, healthful, eating and prevention of obesity. Int J Prev Med. 2012;3(10):672-81.

  10. Cheng JJ, Berry P. Health co-benefits and risks of public health adaptation strategies to climate change: a review of current literatures. Int J Public Health. 2013;58(2):305-11.

  11. Carmo I, Santos O, Camolas J, Vieira J, Carreira M, Medina L, et al. Overweight and obesity in Portugal: national prevalence in 2003-2005. Obes Rev. 2008;9(1):11-9.

  12. Tinker SC, Hammer HC, Berry RJ, Bailey LB, Pfeiffer CM. Does obesity the association of supplemental folic acid with folate status among nonpregnant women of childbearing age in the United States? Birth Defects Res A. Clin Mol Teratol. 2012;94(10):749-55.

  13. Niedworok E, Muc-Wierzgon M, Nowakowska-Zajdel E, Dul L, Klakla K. Magnesium content in daily food portion and the influence of supplementation. Int J Immunopathol Pharmacol. 2011;24(4):975-81.

  14. Panickar KS. Beneficial effects of herbs, species and medicinal plants on the metabolic syndrome, brain and cognitive function. Cent Nerv Syst Agents Med Chem. 2013;13(1):13-29.

  15. Jordan SA, Cunningham DG, Marles RJ. Assesment of herbal medicinal products: challenges and opportunities to increase the knowledge base for safety assessment. Toxicol A Pharmacol. 2010;243(2):198-216.

  16. Cavichioli B, Abourihan CLS, Passoni CMS. Monitoramento da Administração de um suplemento como coadjuvante na perda de peso. Cad Escola Saúde. 2012;1(7):90-110.

  17. Gomes AFC. Pesquisa de Substâncias Ilícitas em Suplementos Alimentares [Mestrado]. Universidade Nova de Lisboa, Setor Ciências e Tecnologia; 2011, 137p.

  18. Onakpoya I, Hung SK, Perry R, Wider B, Ernest E. The Use of Garcinia Extract (Hydroxycitric Acid) as a Weight loss Supplement: A Systematic Review and Meta- Analysis of Randomised Clinical Trials. J Obes. 2011. doi: 10.1155/2011/509038

  19. Veiga Junior VF, Pinto AC. Plantas medicinais: cura segura? Química Nova. 2005;28(3):528-30. [citado agosto 2013]. Disponível em: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100- 40422005000100001&lng=en&nrm=iso&tlng=pt

  20. Rietjens IM, Boersma MG, Van Der Woude H, Jeukissen SM, Schutte ME, Alink GM. Flavonoids and Alkenylbenzenes: mechanisms of mutagenic action and carcinogenic risk. Mut Res. 2005;574(1-2):124-38.

  21. Ferreira PMP, Costa-Lotufo LV, Moraes MO, Barros FWA, Martins AMA, Cavalheiro AJ, et al. Folk uses and pharmacological properties of Casearia sylvestris: a medicinal review. An Acad Bras Ciências. 2011;83(4):1373-84.

  22. Peron AP, Felipes J, Vicentini VEP. Avaliação mutagênica das plantas medicinais Baccharis trimera Less. e Solanum melongena L., em células de medula óssea de ratos Wistar. Rev Bras Bio. 2008;6(2):127-30.

  23. Siqueira KM, Barbosa MA, Brasil VV, Oliveira LMC, Andraus LMS. Crenças populares referentes a saúde: apropriação de saberes sócio-culturais. Texto Cont Enf. 2006;15(1):68-73.

  24. Luo XJ, Peng J, Li YJ. Recent in the study on capsaicinoids and capsinoids. Eur J Pharmacol. 2011;650(1):1-7.

  25. BRASIL. Ministério da Saúde. Agência Nacional de Vigilância Sanitária. Resolução de Diretoria Colegiada no. 48 de 16 de março de 2004. Aprova o regulamento técnico de medicamentos fitoterápico junto ao Sistema Nacional de Vigilância Sanitária. DOU. Diário Oficial da União, Poder Executivo, DF, Brasília, 2004.

  26. Santos ACS, Alvarez MS, Brandão PB, Silva AG. Garcinia cambogia – uma espécie vegetal como recurso terapêutico contra a obesidade? Natureza on line. 2007;5(1):37-43.

  27. Calapai G. European legislation on herbal medicines: a look into the future. Drug Saf. 2008;31(5):428-431.

  28. Saito M, Ueno M, Ogino S, Kubo K, Nagata J, Takeuchi M. High dose of Garcinia cambogia is effective in suppressing fat accumulation in developing male Zucker obese rats, but highly toxic to the testis. Food Chem Toxicol. 2005;43(3):411-19.

  29. Gatta B, Zuberbuehler C, Arnold M, Aubert R, Langhans W, Chapellot D. Acute effects of pharmacological modifications of fatty acid metabolism on human satiety. Br J Nutr. 2009;101(12):1867-77.

  30. Vasudena N, Yadad N, Sharma SK. Natural products: safest approach for obesity. Chin J Integr Med. 2012;18(6):473-480.

  31. Kovacs EMR, Westerterp-Plantenga M. Effects of hydroxycitrate on net fat synthesis as de novo lipogenesis. Physiol Behav. 2006;88(4-5):371-81.

  32. Pal S. Study of lipid profile from RIQAS quality control sample. Indian J Clin Biochem. 2005;20(2):18-23.

  33. Lee SD, Park SK, Lee ES, Kim HM, Lee K, Lee KH, et al. A lipid-soluble red ginseng extract inhibits the growth of human lung tumor xenografts in nude mice. J Med Food. 2010;13(1):1-5.

  34. Deshmukh NS, Bagchi M, Yasmin T, Bagchi D. Safety of a novel calcium (potassium saltof (-) – Hydroxycitric Acid (HCA-SX): II Development toxicity study in rats. Toxicol Mech Met. 2008;18(5):443-51.

  35. Lee KH, Lee BM. Evaluation of the Genotoxicity of (−)-Hydroxycitric Acid (HCASX) Isolated from Garcinia cambogia. J Toxicol Environ Health 2007;70(5):388-92.

  36. Stevens T, Qadri A, Zein NN. Two patients with acute liver injury associated with use of herbal weight-loss supplement hydroxycut. Ann Intern Med. 2005;142(6):477-8.

  37. Shara M, Ohia SE, Yasmin T, Zardetto-Smith A, Kincaid A, Bagchi M, et al. Dose-and time-dependent effects of a novel (-)-hydroxycitric acid extract on body weight, hepatic and testicular lipid peroxidation, DNA fragmentation and histopathological dataover a period of 90 days. Mol Cell Biochem. 2003;254(1-2): 339-46.

  38. Naves A, Paschoal VCP. Regulação funcional da obesidade. Com Scientiae Saúde 2007;6(1):189-99.

  39. Downs BW, Bagchi M, Subbaraju GU, Shara MA, Preuss HG, Bagchi D. Bioefficacy of a novel calcium-potassium salt of (-)-hydroxycitric acid. Mut Res. 2005;579(1-2):149-62.

  40. Reis SB, Oliveira SD, Acedo DD, Miranda DD, Ribeiro ML, Pedrazzoli J, et al. Atenuation of colitis injury in rats using Garcinia combogia extract. Phytother Res. 2009;23(3):324-29.

  41. Hayamizu K, Tomi H, Kaneko I, Shen M, Soni MG, Yoshino G. Effects of Garcinia cambogia extract on serum sex hormones in overweight subjects. Fitoterapia. 2008;79(4):255-61.

  42. Manenti AV. Plantas medicinais utilizadas no tratamento da obesidade: uma revisão [TCC]. Criciúma: Universidade do Extremo Sul Catarinense, Setor de Ciências Biológicas, 2010. 33 p.

  43. Conde WL, Borges C. O risco de incidência e persistência da obesidade entre adultos brasileiros segundo seu estado nutricional ao final da adolescência. Rev Bras Epidemiol. 2011;14(1):71-9.

  44. Leung KW, Wong AS. Pharmacology of ginsenosides: a literature review. American J Chin Med. 2010;5(1):20.

  45. Voces J, Cabral ACO, Prieto JG, Vila L, Perez AC, Duarte ID, et al. Ginseng administration protects skeletal muscle from oxidative stress induced by acute exercise in rats. Braz J Med Biol Res. 2004;37(12):1863-71.

  46. Radad K, Gille G, Liu L, Rausch WD. Use of Ginseng in Medicine With Emphasis on Neurodegenerative Disorders. J Pharmacol Sci. 2006;100(3):175-86.

  47. Auricchio MT, Batistic-Longatto MA, Nicoletti MA. Análise comparativa de embalagens secundárias e bulas de medicamentos contendo Panax ginseng C. A. Meyer. Cad Saude Publica. 2007;23(10):2295-304.

  48. Kumar M, Sharma MK, Saxena PS, Kumar A. Radioprotective effect of Panax ginseng on the phosphatases and lipid peroxidation level in testes of Swiss albino mice. Biol Pharm Bull. 2003;26(3):308-12.

  49. Chan SW. Panax ginseng, Rhodiola rosea and Schisandra chinensis. Int J Food Sci Nutr. 2012;63(Suppl 1):75-81.

  50. Abdel-Aziem SH, Hassan AM, Abdel-Wahhab MA. Dietary supplementation with whey protein and ginseng extract counteracts oxidative stress and DNA damage in rats fed an aflatoxin-contaminated diet. Mut Res. 2011;723(1):65-71.

  51. Volate SR, Davenport DM, Muga SJ, Wargovich MJ. Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin). Carcinogenesis. 2005;26(8):1450-6.

  52. Turolla MSR, Nascimento ES. Informações toxicológicas de alguns fitoterápicos utilizados no Brasil. Rev Bras Cienc Farm. 2006;42(2):289-306

  53. Miller SC, Delorme O, Shan JJ. Extract of North American ginseng (Panax quinquefolius), administered to leukemic, juvenile mice extends their life span. J Complement Integr Med. 2011;8(1). doi: 10.2202/1553-3840.

  54. Kang TH, Park HM, Kim YB, Kim H, Kim W, Do JH, et al. Effects of red ginseng extract on UVB irradiation-induced skin aging in hairless mice. J Ethnopharmacol. 2009;123(3):446-51.

  55. Gursel FE, Ates A, Bilal T, Altiner A. Effect of dietary Garcinia cambogia extract on serum essential minerals (calcium, phosphorus, magnesium) and trace elements (iron, copper, zinc) in rats fed with high-lipid diet. Biol Trace Elem Res. 2012;148(3):378-82.

  56. Sparrebom A, Cox MC, Acharya MR, Figg ND. Herbal remedies in the United States: potential adverse interactions with anticancer agents. Herbs commonly used by women: an evidence-based review. J Clin Oncology. 2004;22(12):2489-503.




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