2015, Number 5
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Ann Hepatol 2015; 14 (5)
Fecal transplant to mitigate hyperammonemia and hepatic encephalopathy in animal models
Joong KD, Hylemon PB, Bajaj JS
Language: English
References: 9
Page: 762-763
PDF size: 56.86 Kb.
Text Extraction
Comment:
The paper by Shen,
et al. reports on efforts to engineer
the gut microbiota to treat hyperammonemia
by decreasing the levels of urease positive gut bacteria.
After treatment of mice with oral antibiotics
and PEG to deplete indigenous bacteria, mice were
inoculated with a consortium of 8 bacteria with low
urease gene content.
REFERENCES
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Surawicz CM. Fecal microbiota transplantation: what we know and what we need to know. Ann Intern Med 2015; 162: 662-3.
Tranah TH, Vijay GK, Ryan JM, Shawcross DL. Systemic inflammation and ammonia in hepatic encephalopathy. Metab Brain Dis 2013; 28: 1-5.
Tandon P, Garcia-Tsao G. Bacterial infections, sepsis, and multiorgan failure in cirrhosis. Semin Liver Dis 2008; 28: 26-42.
Bajaj JS, Gillevet PM, Patel NR, Ahluwalia V, Ridlon JM, Kettenmann B, Schubert CM, et al. A longitudinal systems biology analysis of lactulose withdrawal in hepatic encephalopathy. Metab Brain Dis 2012; 27: 205-15.
Bajaj JS, Heuman DM, Hylemon PB, Sanyal AJ, Puri P, Sterling RK, Luketic V, et al. Randomised clinical trial: Lactobacillus GG modulates gut microbiome, metabolome and endotoxemia in patients with cirrhosis. Aliment Pharmacol Ther 2014; 39: 1113-25.
Bajaj JS, Heuman DM, Hylemon PB, Sanyal AJ, White MB, Monteith P, Noble NA, et al. Altered profile of human gut microbiome is associated with cirrhosis and its complications. J Hepatol 2014; 60: 940-7.
Bajaj JS, Heuman DM, Sanyal AJ, Hylemon PB, Sterling RK, Stravitz RT, Fuchs M, et al. Modulation of the metabiome by ifaximin in patients with cirrhosis and minimal hepatic encephalopathy. PLoS One 2013; 8: e60042.
Vilstrup H, Amodio P, Bajaj J, Cordoba J, Ferenci P, Mullen KD, Weissenborn K, et al. Hepatic encephalopathy in chronic liver disease: 2014 Practice Guideline by the American Association for the Study of Liver Diseases and the European Association for the Study of the Liver. Hepatology 2014; 60: 715-35.